Regulation of cancer progression by PICT1 and development of cancer therapeutics
Project/Area Number |
23592132
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Kagoshima University (2012-2014) Kyushu University (2011) |
Principal Investigator |
KAWAHARA KOHICHI 鹿児島大学, 医歯(薬)学総合研究科, 講師 (00400482)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 核小体ストレス応答 / p53 / がん / 細胞増殖 / 抗癌剤 / レポーターシステム / 薬剤スクリーニング / 癌 / 予後規定因子 / p53経路 / プロテアソーム / 肺癌 / ユビキチン / タンパク質分解 / 脳腫瘍 / 予後関連分子 / 抗がん剤 / 発がん / 腫瘍化進展 / リボソーム蛋白質 / PICT1 / 結合阻害化合物 |
Outline of Final Research Achievements |
Nucleolar stress response is a newly identified mechanism which regulates tumor suppressor p53 protein. We previously identified PICT1 as a novel key regulator of nucleolar stress response. In the present study, we investigated tumor regulatory function of PICT1. We found reduced PICT1 expression decreased cancer cell growth and accumulated p53. In addition, we showed low PICT1 expression associated with better prognosis in cancer patients. These observation suggested that the nucleolar stress response PICT1 regulates could play a definitive role in tumor suppression and, chemicals which induce nucleolar stress response might be attractive cancer therapeutics. Then, we next constructed a reporter system to visualize and quantitate nucleolar stress response. We found that this reporter system allowed quantitative measurement with excellent accuracy. This reporter system may lead to identify novel cancer therapeutics.
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Report
(5 results)
Research Products
(34 results)
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[Journal Article] PICT1 expression is a poor prognostic factor in non-small cell lung cancer.2014
Author(s)
Okamura K, Takayama K, Kawahara K, Harada T, Nishio M, Otsubo K, Ijichi K, Kohno M, Iwama E, Fujii A, Ota K, Koga T, Okamoto T, Suzuki A, Nakanishi Y
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Journal Title
Oncoscience
Volume: 1
Pages: 375-82
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells.2013
Author(s)
Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamoto S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y and Tani K
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Journal Title
Molecular Therapy
Volume: in press
Issue: 6
Pages: 1242-1250
DOI
Related Report
Peer Reviewed
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[Journal Article] PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.2013
Author(s)
Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, Sugimachi K, Maehama T, Mori M, Suzuki A, Komune S, Mimori K
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Journal Title
British Journal of Cancer
Volume: 109
Issue: 8
Pages: 2199-2206
DOI
Related Report
Peer Reviewed
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[Journal Article] Epithelial Pten controls acute lung injury and fibrosis by regulating alveolar epithelial cell integrity2013
Author(s)
Miyoshi K, Yanagi S, Kawahara K, Nishio M, Tsubouchi H, Imazu Y, Koshida R, Matsumoto N, Taguchi A, Yamashita S, Suzuki A, Nakazato M
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Journal Title
Am J Respir Crit Care Med
Volume: 187
Issue: 3
Pages: 262-275
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL112011
Author(s)
Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
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Journal Title
Nat Med
Volume: 17
Issue: 8
Pages: 944-951
DOI
Related Report
Peer Reviewed
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[Journal Article] Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers2011
Author(s)
Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M
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Journal Title
Cancer Res
Volume: 71
Issue: 20
Pages: 6320-6
DOI
Related Report
Peer Reviewed
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[Presentation] 核小体ストレス応答による腫瘍進展制御と革新的抗癌治療薬の創生2015
Author(s)
川畑 拓斗, 河原 康一, 堀口 史人, 上條 陽平, 山本 雅達, 新里 能成, 南 謙太朗, F.M MOINUDDIN, 田辺 寛,藤本 啓汰, 土屋 理佐子, 有馬 一成、 濱田 季之, 古川 龍彦
Organizer
日本薬学会総会
Place of Presentation
神戸(兵庫医療大学)
Year and Date
2015-03-25 – 2015-03-28
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[Presentation] PICT1, a PTEN stabilizing protein, is a critical nucleolar latch of RPL11 to regulate MDM2-p53 pathway and tumor growth
Author(s)
Kawahara K, Sasaki M, Nishio M, Mimori K, Kogo R, Maehama T, Sasaki T, Mori M, Suzuki A.
Organizer
International Symposium New Aspects of Phospholipid Biology and Medicine(招待講演)
Place of Presentation
福岡
Related Report
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