| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
Folate receptor-beta (FRb) is over expressed in tissue-activated macrophages in autoimmune diseases and some tumors (e.g. glioblastoma). We previously determined that FRb-macrophages in glioma may play a role to promote tumor growth.
The present study evaluated the efficacy of targeting of FRb-macrophages by anti-FRb immunotoxin for treating immunotherapy of weakly immunogenic F98 glioma rat models. Fischer rats received an intracerebral implantation of F98 cells. After 3 days, subcutaneous administration of vaccination (freeze/thaw treated F98) were performed in presence/absence of immunotoxin (intraperitoneal administration). However, no significant differences in survival times were observed. When combined liveing cell F98 and immunotoxin administration enhanced survival times, but significance was not observed. We investigated the presence of anti-immunotoxin antibodies. We further developed newly immunotoxin which showed low immunogenicity and used for long-term administration.
|
