| Project/Area Number |
23592135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
HIRANO Hirofumi 鹿児島大学, 医学部・歯学部附属病院, 講師 (00264416)
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| Co-Investigator(Kenkyū-buntansha) |
KISHIDA Shosei 鹿児島大学, 医歯学総合研究科, 教授 (50274064)
ARITA Kazunori 鹿児島大学, 医歯学総合研究科, 教授 (90212646)
YUNOUE Shunji 鹿児島大学, 医歯学総合研究科, 客員研究員 (20404478)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | glioblastoma / Wnt-5a / MMP-2 / Fzd2 / Fzd6 / Ryk / Ror2 / invasion / Wnt5a / Frizzled2 / Frizzled6 / Glioblastoma / Survival time / Wnt / Frizzled / 悪性グリオーマ / 膠芽腫 / 増殖 / 浸潤 / 生命予後 |
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| Research Abstract |
Glioblastoma, one of the most malignant brain tumors, invade surrounding brain by expression of MMPs. Wnts, secretory proteins bind to their receptors, Fzd, Ror2, and Ryk. We previously reported that Wnt-5a was highly expressed and it up-regulated MMP-2 in glioblastoma.
In this work, we revealed that tumor cell invasion by MMP-2 was achieved via receptor Ryk, and the degree of histological malignancy correlated with expression of Fzd2 and Ryk (J Biochem 2014, doi: 10.1093/jb/mvu015). In another analysis, we reported that high expression of Fzd2 and Fzd6 was poor prognostic factor in glioblastoma patients (Brain Tumor Pathol 2013, 10.1007/s10014-013-0153-1).
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