Investigation of molecular genetic alterations and prognostic factors of primary central nervous system lymphoma
| Project/Area Number |
23592140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGANE Motoo 杏林大学, 医学部, 教授 (60327468)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 悪性リンパ腫 / 脳腫瘍 / 遺伝子解析 / 予後因子 / 治療感受性 / Germinal center / MGMT / Mismatch repair / ゲノム解析 |
|---|
| Research Abstract |
We investigated prognostic markers for primary central nervous system lymphoma (PCNSL) using immunohistochemistry. Age and KPS were strong prognosticators as reported previously. Methotrexate-based chemoradiotherapy achieved a high rate of complete response (83%), improving survival of PCNSL patients. Multiplicity of PCNSL lesions was significantly associated with a short survival. High expression of LRP, drug efflux pump protein, was associated with a poor response to chemotherapy and shorter overall survival, suggesting that LRP may be a clinically relevant drug-resistance factor in PCNSL. Expression of a germinal center marker Bcl-6 was a favorable prognostic factor, whereas c-myc high protein expression was associated with an inferior survival. Low protein expression of mismatch repair proteins, MLH1, MSH2 and MSH6, was a significant indicator for a short survival in patients with PCNSL.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Reduced Estimated Glomerular Filtration Rate is Associated with Stroke Outcome after Intravenous rt-PA:The Stroke Acute Management with Urgent Rsk-Factor Assessment and Improvement (SAMURAI) rt-PA Registry2011
Author(s)
Naganuma M, Koga M, Shiokawa Y, Nakagawa J, Furui E, Kimura K, Yamagami H, Okada Y, Hasegawa Y, Kario K, Okuda S, Nishiyama K, Minematsu K, Toyoda K
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Journal Title
Cerebrovasc Dis
Volume: 31
Pages: 12-129
Related Report
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[Journal Article] Early Ischemic Change on CT Versus Diffusion-Weighted Imaging for Patients With Stroke Receiving Intravenous Recombinant Tissue-Type Plasminogen Activator Therapy2011
Author(s)
Nezu T, Koga M, Nakagawara J, Shiokawa Y, Yamagami H, Furui E, Kimura K, Hasegawa Y, Okada Y, Okuda S, Kario K, Naganuma M, Maeda K, Minematsu K, Toyoda K
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Journal Title
Stroke
Volume: 42
Pages: 2196-2200
Related Report
Peer Reviewed
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