Pathogenesis and treatment of cognitive dysfunction induced by reduced clearance of cerebrospinal fluid associated with aging
| Project/Area Number |
23592142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 老化 / 髄液 / 認知機能障害 / 水頭症 / クリアランス / LRG1 / 髄液のクリアランス / グリア細胞 / 神経細胞変性 / トランスジェニックマウス / 水チャンネル / neurodegeneration / transgenic mouse / 特発性正常圧水頭症 / アストロサイト / 神経細胞 |
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| Research Abstract |
The function of LRG in the brain during aging and neurodegenerative diseases has not been investigated. Here, we observed hLRG expression in post-mortem human cerebral cortex. We then generated transgenic mice that over-expressed mouse LRG in the brain to examine the effects of mLRG accumulation. Our results show that in both humans and mouse brains, LRG increases with age. Increased LRG in neurons and glial cells was associated with mouse cerebral cortex neurodegeneration.
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Report
(4 results)
Research Products
(11 results)
