Identification of molecules affecting ACTH secretion and establishment of novel therapy of pituitary adenomas

• Project/Area Number: 23592143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Teikyo University
• Principal Investigator: MATSUNO AKIRA 帝京大学, 医学部, 教授 (00242058)
• Co-Investigator(Renkei-kenkyūsha): MIZUTANI Akiko 帝京平成大学, 健康メディカル学部, 講師 (80465252) ; TAKEKOSHI Susumu 東海大学, 医学部, 准教授 (70216878) ; OSAMURA Yoshiyuki 国際医療福祉大学, 大学病院健康, 教授 (10100992)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ACTH / 下垂体細胞 / 分泌顆粒 / 下垂体

Research Abstract

We focused on adrenocorticotropic hormone and tried to identify and suppress novel molecules playing major roles on formation and intracellular transport of secretory granules. Cells continuously overexpressing ACTH were newly established through transfection to AtT20 cells of GFP-fused wild ACTH and high molecular weight ACTH using episomal vector. Under confocal laser microscopy, intracellular localization of ACTH secretory granules and secretion of ACTH stimulated by CRH and extracellular high potassium were observed. The dynamics of ACTH secretory granules under plasma membrane was also observed under total internal reflection fluorescence microscopy.

Research Products

• [Journal Article] Urinary growth hormone level and insulin-like growth factor-1 standard deviation score (IGF-SDS) can discriminate adult patients with severe growth hormone deficiency (2013)
  • Author(s): Hirohata T, Saito N, Takano K, Yamada S, Son JH, Yamada SM, Nakaguchi H, Hoya K, Murakami M, Mizutani A, Okinaga H, Matsuno A
  • Journal Title: Endocr J Volume: 60 Pages: 369-373
  • NAID: 10031170622
  • Peer Reviewed
• [Journal Article] DNA mismatch repair protein (MSH6) correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide : The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2013)
  • Author(s): Hirohata T, Asano K, Ogawa Y, Takano S, Amano K, Isozaki O, Iwai Y, Sakata K, Fukuhara N, Nishioka H, Yamada S, Fujio S, Arita K, Takano K, Tominaga A, Hizuka N, Ikeda H, Osamura RY, Tahara S, Ishii Y, Kawamata T, Shimatsu A, Teramoto A, Matsuno A
  • Journal Title: J Clin Endocri Metab Volume: 98 Pages: 1130-1136
  • Peer Reviewed
• [Journal Article] A skull base osteosarcoma presenting with cerebrospinal fluid leaking in CyberKnife treatment : a case report (2013)
  • Author(s): Yamada SM, Ishii Y, Yamada S, Goto Y, Murakami M, Hoya K, Matsuno A
  • Journal Title: J Med Case Reports Volume: 7 Pages: 116-110
  • Peer Reviewed
• [Journal Article] Modified S/MAR episomal vectors for stably expressing fluorescent-protein tagged transgenes with small cell-to-cell fluctuations (2013)
  • Author(s): Mizutani A, Kikkawa E, Matsuno A, Shigenari A, Okinaga H, Murakami M, Ishida H, Tanaka M, Inoko H
  • Journal Title: Anal Biochem Volume: 443 Pages: 113-116
  • Peer Reviewed
• [Journal Article] Clinicopathological and molecular histochemical review of skull base metastasis from differentiated thyroid carcinoma (2013)
  • Author(s): Matsuno A, Murakami M, Hoya K, Yamada SM, Miyamoto S, Yamada S, Son JH, Nishido H, Ide F, Nagashima H, Sugaya M, Hirohata T, Mizutani A, Okinaga H, Ishii Y, Tahara S, Teramoto A, Osamura RY, Yamazaki K, Ishida Y
  • Journal Title: Acta Histochem Cytochem Volume: 46 Pages: 129-136
  • NAID: 130003381867
  • Peer Reviewed
• [Journal Article] DNA mismatch repair protein (MSH6) correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide: The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2013)
  • Author(s): Hirohata T, (22名省略）, Matsuno A
  • Journal Title: J Clin Endocri Metab Volume: 98 Pages: 1130-1136
  • Peer Reviewed
• [Journal Article] A skull base osteosarcoma presenting with cerebrospinal fluid leaking in CyberKnife treatment: a case report (2013)
  • Author(s): Yamada SM, Ishii Y, Yamada S, Goto Y, Murakami M, Hoya K, Matsuno A
  • Journal Title: J Med Case Reports Volume: 7 Pages: 116-110
  • Peer Reviewed
• [Journal Article] 術前診断に苦慮した鞍上部腫瘍の1例 (2013)
  • Author(s): 廣畑倫生、後藤芳明、山田創、山田昌興、中口博、保谷克巳、村上峰子、石井雄道、寺本明、山﨑一人、石田康生、松野彰
  • Journal Title: 日本内分泌学会雑誌 Volume: 89[Suppl, Aug] Pages: 88-91
• [Journal Article] V.よくみられる神経疾患 C. 脳腫瘍 / 脊髄腫瘍 良性脳腫瘍 (2013)
  • Author(s): 松野彰、村上峰子
  • Journal Title: 日本医師会雑誌 第142巻・特別号（２）（生涯教育シリーズ８５） 神経・精神疾患診療マニュアル Volume: 142
• [Journal Article] 傍鞍部髄膜腫 (2013)
  • Author(s): 廣畑倫生、松野彰
  • Journal Title: ホルモンと臨床 特集 下垂体腺腫と鑑別を要するトルコ鞍近傍疾患 Volume: 特集 Pages: 47-52
• [Journal Article] 臨床医のための神経病理 下垂体癌 (2013)
  • Author(s): 長村義之、井野元智恵、松野彰、田原重志、寺本明
  • Journal Title: Clinical Neuroscience Volume: 31 Pages: 1240-1241
• [Journal Article] Advanced therapeutic strategy for radiation-induced osteosarcoma at the skull base : a case report and review (2012)
  • Author(s): Yamada SM, Ishii Y, Kuribayashi S, Kumita S, Matsuno A
  • Journal Title: Radiat Oncol Volume: 7 Pages: 136-140
  • Peer Reviewed
• [Journal Article] Endoscopic extracapsular removal of pituitary adenoma : the importance of pretreatment of an adjacent unruptured internal carotid artery aneurysm (2012)
  • Author(s): Yamada S, Yamada SM, Hirohata T, Ishii Y, Hoya K, Murakami M, Matsuno A
  • Journal Title: Case Report Neurol Med Volume: 2012 Pages: 891847-891847
• [Journal Article] 日本間脳下垂体腫瘍学会全国調査における下垂体癌・異型性下垂体腺腫の病理学的解析 (2012)
  • Author(s): 廣畑倫生、松野彰、山田正三、有田和徳、高野幸路、冨永篤、肥塚直美、池田秀敏、佐野壽昭、長村義之、田原重志、川俣貴一、石井雄道、寺本明
  • Journal Title: ACTH RELATED PEPTIDES Volume: 22 Pages: 34-37
• [Journal Article] ヒト肺小細胞がん株（DMS-79）における POMC ならびにソマトスタチン（SRIF）の遺伝子発現と産生に関する検討：γ3-MSH と大分子 ACTH の解析 (2012)
  • Author(s): 片上秀喜、奈須和幸、鎌田陽子、松野彰、橋田誠一
  • Journal Title: ACTH RELATED PEPTIDES Volume: 22 Pages: 49-51
• [Journal Article] クッシング病と異所性ACTH産生症候群との鑑別診断：big ACTHとproγMSHにたいする超高感度・高感度測定法の開発と臨床応用 (2012)
  • Author(s): 片上秀喜、奈須和幸、橋田誠一、宮村信博, 松野彰、肥塚直美、山田正三
  • Journal Title: 日本内分泌学会雑誌 Volume: 88[Suppl, Aug] Pages: 49-51
• [Journal Article] 日本間脳下垂体腫瘍学会全国調査における、下垂体癌・異型性下垂体腺腫の病理学的解析 (2012)
  • Author(s): 廣畑倫生、松野彰、山田正三、有田和徳、高野幸路、冨永篤、肥塚直美、池田秀敏、佐野壽昭、長村義之、田原重志、川俣貴一、石井雄道、寺本明
  • Journal Title: 日本内分泌学会雑誌 Volume: 88[Suppl, Aug] Pages: 64-67
• [Journal Article] Advanced therapeutic strategy for radiation-induced osteosarcoma at the skull base: a case report and review (2012)
  • Author(s): Yamada SM, Ishii Y, Kuribayashi S, Kumita S, Matsuno A
  • Journal Title: Radiat Oncol Volume: 7 Pages: 136-140
  • Peer Reviewed
• [Journal Article] Running–induced headaches in an aqueduct stenosis patient. (2012)
  • Author(s): Yamada SM, Matsuno A, Yamada S
  • Journal Title: Childs Nerv Syst Volume: 28 Issue: 8 Pages: 1265-1268
  • DOI: 10.1007/s00381-012-1742-8
  • Peer Reviewed
• [Journal Article] Tumefactive multiple sclerosis requiring emergent biopsy and histological investigation to confirm the diagnosis: a case report (2012)
  • Author(s): Yamada S, Yamada SM, Nakaguchi H, Murakami M, Hoya K, Matsuno A, Yamazaki K, Ishida Y
  • Journal Title: J Med Case Rep Volume: 6 Pages: 104-107
  • Peer Reviewed
• [Journal Article] Ganglioneuroma originating from the trigeminal nerve in the middle cranial fossa (2012)
  • Author(s): Nakaguchi H, Murakami M, Matsuno A, Yamazaki K, Ishida Y
  • Journal Title: Neurol Med-Chir (Tokyo) Volume: 52 Pages: 95-98
  • Peer Reviewed
• [Journal Article] A simple and consistent technique for ventricular catheter insertion using a tripod (2012)
  • Author(s): Yamada SM, Yamada S, Goto Y, Nakaguchi H, Murakami M, Hoya K, Matsuno A
  • Journal Title: Clin Neurol Neurosurg Volume: 114 Pages: 622-626
  • Peer Reviewed
• [Journal Article] Abnormal dynamics of growth hormone after thyrotropin-releasing hormone loading test, gonadotropin-releasing hormone loading test, and oral glucose tolerance test in mixed gonadal dysgenesis with a pituitary lesion (2011)
  • Author(s): Matsuno A, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M
  • Journal Title: International Journal of Case Reports and Images (IJCRI) Volume: 2 Pages: 12-14
  • Peer Reviewed
• [Journal Article] A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma : case report (2011)
  • Author(s): Murakami M, Mizutani A, Asano S, Katakami H, Ozawa Y, Yamazaki K, Ishida Y, Takano K, Okinaga H, Matsuno A
  • Journal Title: Neurosurgery Volume: 68
  • Peer Reviewed
• [Journal Article] Functional molecular morphology of anterior pituitary cells, from hormone production to intracellular transport and secretion (2011)
  • Author(s): Matsuno A, Mizutani A, Okinaga H, Takano K, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M, Takeuchi M, Sugaya M, Itoh J, Takekoshi S, Osamura RY
  • Journal Title: Med Mol Morphol Volume: 44 Pages: 63-70
  • NAID: 10029036664
  • Peer Reviewed
• [Journal Article] Molecular morphology of pituitary cells, from conventional immunohistochemistry to fluorescence imaging (2011)
  • Author(s): Matsuno A, Mizutani A, Okinaga H, Takano K, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M, Takeuchi M, Sugaya M, Itoh J, Takekoshi S, Osamura RY
  • Journal Title: Molecules Volume: 16 Pages: 3618-3635
  • Peer Reviewed
• [Journal Article] Molecular morphological research of anterior pituitary hormone production, intracellular transport and secretion (2011)
  • Author(s): Matsuno A, Mizutani A, Okinaga H, Takano K, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M, Takeuchi M, Sugaya M, Itoh J, Takekoshi S, Osamura RY
  • Journal Title: Trends in Cell and Molecular Biology Volume: 6 Pages: 1-8
  • Peer Reviewed
• [Journal Article] A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma: case report (2011)
  • Author(s): Murakami M, Mizutani A, Asano S, Katakami H, Ozawa Y, Yamazaki K, Ishida Y, Takano K, Okinaga H, Matsuno A
  • Journal Title: Neurosurgery Volume: 68
  • Peer Reviewed
• [Journal Article] Abnormal dynamics of growth hormone after thyrotropin-releasing hormone loading test, gonadotropin-releasing hormone loading test, and oral glucose tolerance test in mixed gonadal dysgenesis with a pituitary lesion (2011)
  • Author(s): Matsuno A, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M
  • Journal Title: International Journal of Case Reports and Images Volume: 2 Pages: 12-14
  • Peer Reviewed
• [Journal Article] Molecular morphology of pituitary cells, from conventional immunohistochemistry to fluorescein imaging (2011)
  • Author(s): Matsuno A, Mizutani A, Okinaga H, Takano K, Yamada S, Yamada SM, Nakaguchi H, Hoya K, Murakami M, Takeuchi M, Sugaya M, Itoh J, Takekoshi S, Osamura RY
  • Journal Title: Molecules Volume: 16 Pages: 3618-3635
  • Peer Reviewed
• [Journal Article] 下垂体癌とそのテモゾロマイド治療に関する全国調査 (2011)
  • Author(s): 松野彰、山田正三、有田和徳、高野幸路、冨永篤、肥塚直美、池田秀敏、佐野壽昭、長村義之、田原重志、川俣貴一、石井雄道、廣畑倫生、寺本明
  • Journal Title: 日本内分泌学会雑誌 Volume: 87[Suppl, Aug] Pages: 85-86
• [Presentation] DNA mismatch repair protein MSH6 correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide : The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2013)
  • Author(s): Matsuno A
  • Organizer: The 15^<th> World Congress of Neurosurgery (WFNS)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2013-09-10
• [Presentation] DNA mismatch repair protein MSH6 correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide : The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2013)
  • Author(s): Matsuno A
  • Organizer: The 24th Annual Meeting of Asia-Pacific Endocrine Conference (APEC)
  • Place of Presentation: Dalian, China
  • Year and Date: 2013-07-14
• [Presentation] Effect of intensive resection of pseudocapsule on surgical results in no-functioning pituitary macroadenomas (2013)
  • Author(s): Ishii Y, Matsuno A, Tahara S, Teramoto A, Morita A
  • Organizer: The 24th Annual Meeting of Asia-Pacific Endocrine Conference (APEC)
  • Place of Presentation: Dalian, China
  • Year and Date: 2013-07-14
• [Presentation] DNA mismatch repair protein MSH6 correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide : The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2013)
  • Author(s): Matsuno A
  • Organizer: The 6^<th> International Mt. BANDAI Symposium for Neuroscience & The 7^<th> Pan-Pacific Neurosurgery Congress (Joint Neurosurgical Convention)
  • Place of Presentation: Hawaii
  • Year and Date: 2013-02-02
• [Presentation] Novel and highly sensitive EIAs for the differential diagnosis (DDx) between Cushing’s disease (CD) and ectopic ACTH symdrome (EAS) (2013)
  • Author(s): Katakami H, Hashida S, Miyamura N, Matsuno A, Hizuka N, Yamada S
  • Organizer: The 13th IInternational Pituitary Congress
  • Place of Presentation: San Francisco
• [Presentation] DNA mismatch repair protein MSH6 correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide: The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2013)
  • Author(s): Matsuno A
  • Organizer: The 24th Annual Meeting of Asia-Pacific Endocrine Conference (APEC)
  • Place of Presentation: Dalian
• [Presentation] Effect of intensive resection of pseudocapsule on surgical results in no-functioning pituitary macroadenomas (2013)
  • Author(s): Ishii Y, Matsuno A, Tahara S, Teramoto A, Morita A
  • Organizer: The 24th Annual Meeting of Asia-Pacific Endocrine Conference (APEC)
  • Place of Presentation: Dalian
• [Presentation] DNA mismatch repair protein MSH6 correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide: The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2013)
  • Author(s): Matsuno A
  • Organizer: The 15th World Congress of Neurosurgery (WFNS)
  • Place of Presentation: Seoul
• [Presentation] Diagnosis of adult tethered cord syndrome (2013)
  • Author(s): Yamada SM, Yamada S, Won D, Colohan A, Matsuno A
  • Organizer: The 15th World Congress of Neurosurgery (WFNS)
  • Place of Presentation: Seoul
• [Presentation] Glioblastoma multiforme (GBM) relative to the precursor in C6 cell culture (2013)
  • Author(s): Yamada SM, Matsuno A, Yamada S
  • Organizer: The 15th World Congress of Neurosurgery (WFNS)
  • Place of Presentation: Seoul
• [Presentation] A case of aqueduct stenosis with a running-induced headache (2013)
  • Author(s): Yamada SM, Yamada S, Yamada S, Hosono A, Goto Y, Son JH, Murakami M, Hoya K, Matsuno A
  • Organizer: The 15th World Congress of Neurosurgery (WFNS)
  • Place of Presentation: Seoul
• [Presentation] 骨粗鬆症とホルモン異常、その治療 (2013)
  • Author(s): 松野彰
  • Organizer: 第3回伸緑医会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 特別セミナー：下垂体腫瘍に対する最新のトピックス 先端巨大症の内科的治療 (2013)
  • Author(s): 松野彰
  • Organizer: 第72回日本脳神経外科学会学術総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] とことん神経内分泌 間脳下垂体腫瘍の外科的治療 (2013)
  • Author(s): 松野彰
  • Organizer: 第40回日本神経内分泌学会学術総会
  • Place of Presentation: 宮崎
  • Invited
• [Presentation] 先端巨大症の病態と薬物治療 (2013)
  • Author(s): 松野彰
  • Organizer: 第40回日本神経内分泌学会学術総会
  • Place of Presentation: 宮崎
  • Invited
• [Presentation] 下垂体ホルモン分泌異常症：診断と治療update、骨とQOLはどうなる？ (2013)
  • Author(s): 松野彰
  • Organizer: 千葉県松戸地区高齢者疾患フォーラム2013
  • Place of Presentation: 松戸
  • Invited
• [Presentation] 成長ホルモン分泌異常症（先端巨大症と成人成長ホルモン欠損症） (2013)
  • Author(s): 松野彰
  • Organizer: 第14回日本内分泌学会中国支部学術集会
  • Place of Presentation: 広島
  • Invited
• [Presentation] Functional molecular morphology of pituitary cells, from conventional immunohistochemistry to fluorescein imaging (2012)
  • Author(s): Matsuno A, Mizutani A, Murakami M, Hoya K, Nakaguchi H, Yamada SM, Hirohata T, Ishibashi S, Okinaga H
  • Organizer: The 14^<th> International Congress of Histochemistry and Cytochemistry (ICHC2012)
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-27
• [Presentation] Analyses of factors influencing the acute effect of octreotide in growth hormone-secreting adenomas (2012)
  • Author(s): Ishibashi S, Matsuno A, Mizutani A, Murakami M, Hoya K, Nakaguchi H, Yamada SM, Hirohata T, Okinaga H
  • Organizer: The 14^<th> International Congress of Histochemistry and Cytochemistry (ICHC2012)
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-27
• [Presentation] A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma (2012)
  • Author(s): Murakami M, Mizutani A, Hoya K, Matsuno A
  • Organizer: The 14^<th> International Congress of Histochemistry and Cytochemistry (ICHC2012)
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-27
• [Presentation] Identification of a novel interactor of human growth hormone (2012)
  • Author(s): Mizutani A, Matsuno A, Hirohata T, Tanaka M, Inoko H
  • Organizer: The 14^<th> International Congress of Histochemistry and Cytochemistry (ICHC2012)
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-27
• [Presentation] DNA mismatch repair protein MSH6 correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide : The national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors (2012)
  • Author(s): Hirohata T, Matsuno A, Osamura RY, Teramoto A
  • Organizer: The 14^<th> International Congress of Histochemistry and Cytochemistry (ICHC2012)
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-27
• [Presentation] Studies of the Japan Society for Hypothalamic and Pituitary Tumors : Temozolomide treatment of pituitary carcinoma and atypical adenoma (2012)
  • Author(s): Matsuno A
  • Organizer: The 5th Harbin International Neurosurgical Conference
  • Place of Presentation: Harbin, China
  • Year and Date: 2012-07-15
• [Presentation] Studies of the Japan Society for Hypothalamic and Pituitary Tumors: Temozolomide treatment of pituitary carcinoma and atypical adenoma (2012)
  • Author(s): Matsuno A
  • Organizer: The 5th Harbin International Neurosurgical Conference
  • Place of Presentation: Harbin, China
  • Invited
• [Presentation] 下垂体腫瘍の診断と治療：過去から未来へ (2012)
  • Author(s): 松野彰
  • Organizer: 第4回Musashi-脳神経外科講演会
  • Place of Presentation: 大宮
  • Invited
• [Presentation] 下垂体および近傍疾患患者における成人成長ホルモン欠損症(AGHD)の簡便な診断と治療 (2012)
  • Author(s): 松野彰、廣畑倫生、高野幸路
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 偶発的下垂体腫瘍におけるsubclinical adenoma (2012)
  • Author(s): 松野彰、廣畑倫
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 先端巨大症の薬物療法 (2012)
  • Author(s): 松野彰
  • Organizer: GH/IGF-1学術講演会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 先端巨大症の薬物治療 (2012)
  • Author(s): 松野彰
  • Organizer: 第10回千葉下垂体疾患研究会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] 先端巨大症の手術と薬物療法 (2012)
  • Author(s): 松野彰
  • Organizer: 第3回兵庫間脳下垂体疾患フォーラム
  • Place of Presentation: 神戸
  • Invited
• [Presentation] Functional molecular morphology of pituitary cells, from conventional immunohistochemistry to fluorescein imaging (2011)
  • Author(s): Matsuno A, Mizutani A, Hoya K, Murakami M, Ishibashi S, Okinaga H
  • Organizer: The 10^<th> China-Japan Joint Seminar on Histochemistry and Cytochemistry (CJJSHC)
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-23
• [Presentation] Functional molecular morphology of pituitary cells, from conventional immunohistochemistry to fluorescein imaging (2011)
  • Author(s): Matsuno A
  • Organizer: Capital Medical University
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-04-14
• [Presentation] Temozolomide treatment of malignant pituitary adenomas (2011)
  • Author(s): Matsuno A, Murakami M, Mizutani A, Nakaguchi H, Yamada SM, Hoya K, Asano S, Ozawa Y, Yamazaki K, Ishida Y, Okinaga H
  • Organizer: The 4th International Neurosurgical Winter Congress
  • Place of Presentation: Rusutsu, Hokkaido, Japan
  • Year and Date: 2011-02-09
• [Presentation] Differential diagnosis among patients with total thyroidectomy, thyroid dysgenesis and mutations in the thyroglobulin gene by a novel ultrasensitive EIA for human thyroglobulin (2011)
  • Author(s): Katakami H, Hashida S, Iwasaki H, Hishinuma A, Fukata S, Matsuno A
  • Organizer: Ieiri T. ENDO 2011
  • Place of Presentation: Boston, USA
• [Presentation] A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma (2011)
  • Author(s): Murakami M, Mizutani A, Hoya K, Matsuno A
  • Organizer: The 10^<th> China-Japan Joint Seminar on Histochemistry and Cytochemistry (CJJSHC)
  • Place of Presentation: Beijing, China
• [Presentation] Identification of novel interaction partners for human growth hormone (hGH) by the yeast two hybrid system (2011)
  • Author(s): Mizutani A, Tanaka M, Yoshimura S, Okinaga H, Takano K, Inoko H , Matsuno A
  • Organizer: The 10^<th> China-Japan Joint Seminar on Histochemistry and Cytochemistry (CJJSHC)
  • Place of Presentation: Beijing, China
• [Presentation] Analyses of factors influencing the acute effect of octreotide in growth hormone-secreting adenomas (2011)
  • Author(s): Ishibashi S, Matsuno A, Mizutani A, Hoya K, Murakami M, Okinaga H
  • Organizer: The 10^<th> China-Japan Joint Seminar on Histochemistry and Cytochemistry (CJJSHC)
  • Place of Presentation: Beijing, China
• [Presentation] Functional molecular morphology of pituitary cells, from conventional immunohistochemistry to fluorescein imaging (2011)
  • Author(s): Matsuno A
  • Organizer: Capital Medical University(招待講演)
  • Place of Presentation: Beijing, China
• [Presentation] Functional molecular morphology of pituitary cells, from conventional immunohistochemistry to fluorescein imaging (2011)
  • Author(s): Matsuno A, Mizutani A, Hoya K, Murakami M, Ishibashi S, Okinaga H
  • Organizer: The 10th China-Japan Joint Seminar on Histochemistry and Cytochemistry(招待講演)
  • Place of Presentation: Beijing, China
• [Presentation] 下垂体近傍腫瘍に関する成人GHD診断と治療の実践 (2011)
  • Author(s): 松野彰、岡崎亮、高野幸路
  • Organizer: 第84回日本内分泌学会学術総会シンポジウム(招待講演)
  • Place of Presentation: 神戸
• [Presentation] 下垂体部腫瘍と臨床内分泌 (2011)
  • Author(s): 松野彰
  • Organizer: 第28回脳神経外科生涯教育研修会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 日本間脳下垂体腫瘍学会全国調査における、下垂体癌・異型性下垂体腺腫の病理学的解析 (2011)
  • Author(s): 廣畑倫生、松野彰、山田正三、有田和徳、高野幸路、冨永篤、肥塚直美、池田秀敏、佐野壽昭、長村義之、田原重志、川俣貴一、石井雄道、寺本明
  • Organizer: 第22回間脳・下垂体・副腎系研究会(招待講演)
  • Place of Presentation: 東京
• [Presentation] A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma (2011)
  • Author(s): Murakami M, Mizutani A, Hoya K, Matsuno A
  • Organizer: The 10th China-Japan Joint Seminar on Histochemistry and Cytochemistry
  • Place of Presentation: Beijing, China
• [Presentation] Identification of novel interaction partners for human growth hormone (hGH) by the yeast two hybrid system (2011)
  • Author(s): Mizutani A, Tanaka M, Yoshimura S, Okinaga H, Takano K, Inoko H , Matsuno A
  • Organizer: The 10th China-Japan Joint Seminar on Histochemistry and Cytochemistry
  • Place of Presentation: Beijing, China
• [Presentation] Analyses of factors influencing the acute effect of octreotide in growth hormone-secreting adenomas (2011)
  • Author(s): Ishibashi S, Matsuno A, Mizutani A, Hoya K, Murakami M, Okinaga H
  • Organizer: The 10th China-Japan Joint Seminar on Histochemistry and Cytochemistry
  • Place of Presentation: Beijing, China
• [Book] 4.脳腫瘍 トルコ鞍部腫瘍非機能性下垂体腺腫. 今日の神経疾患治療指針第2版 (2013)
  • Author(s): 松野彰. 水澤英洋、鈴木則宏、梶龍兒、吉良潤一、神田隆、齊藤延人 編
  • Publisher: 医学書院
• [Book] 第5章生化学検査 A.下垂体. 標準臨床検査医学第4版 (2013)
  • Author(s): 松野彰.高木康、山田俊幸 編
  • Publisher: 医学書院
• [Book] 今日の治療指針2013年版私はこう治療している (2013)
  • Author(s): 松野彰
  • Publisher: 医学書院
• [Book] IV. 間脳・下垂体・傍鞍部の治療 悪性下垂体腺腫―異型性下垂体腺腫、下垂体癌. ビジュアル脳神経外科6間脳・下垂体・傍鞍部 (2013)
  • Author(s): 廣畑倫生、村上峰子、松野彰. 齋藤延人 編
  • Publisher: メジカルビュー社
• [Book] 今日の神経疾患治療指針 第2版 (2013)
  • Author(s): 松野彰
  • Total Pages: 3
  • Publisher: 医学書院
• [Book] 標準臨床検査医学第4版 (2013)
  • Author(s): 松野彰
  • Total Pages: 13
  • Publisher: 医学書院
• [Book] 今日の治療指針2013年版 私はこう治療している (2013)
  • Author(s): 松野彰
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] ビジュアル脳神経外科６ 間脳・下垂体・傍鞍部 (2013)
  • Author(s): 廣畑倫生、村上峰子、松野彰
  • Total Pages: 10
  • Publisher: メジカルビュー社
• [Book] 改訂版 Acromegaly Handbook アクロメガリーハンドブック (2013)
  • Author(s): 松野彰、廣畑倫生、水谷晃子
  • Total Pages: 3
  • Publisher: メディカルレビュー社
• [Book] 改訂版 Acromegaly Handbook アクロメガリーハンドブック (2013)
  • Author(s): 廣畑倫生、水谷晃子、松野彰
  • Total Pages: 2
  • Publisher: メディカルレビュー社
• [Book] インフォームドコンセントのための図説シリーズ 脳腫瘍 (2013)
  • Author(s): 松野彰
  • Total Pages: 6
  • Publisher: 医薬ジャーナル社
• [Book] 11章 脳腫瘍 §8 脳腫瘍各論(6) 下垂体腺腫、頭蓋咽頭腫. 脳神経外科学 改訂第11版 (2012)
  • Author(s): 松野彰. 太田富雄 総編 川原信隆、西川亮、野崎和彦、吉峰俊樹 編
  • Publisher: 金芳堂
• [Book] 各論編 第2章 基礎知識D. 下垂体前葉疾患各論35. 下垂体癌と異型性下垂体腺腫. 下垂体疾患診療マニュアル診断と治療 (2012)
  • Author(s): 松野彰、村上峰子、水谷晃子. 平田結喜緒、山田正三、成瀬光栄 編
• [Book] 脳神経外科学 改訂第11版 太田富雄 総編 川原信隆、西川亮、野崎和彦、吉峰俊樹 編 (2012)
  • Author(s): 松野彰
  • Publisher: 金芳堂 京都
• [Book] 下垂体疾患診療マニュアル 平田結喜緒、山田正三、成瀬光栄 編 (2012)
  • Author(s): 松野彰、村上峰子、水谷晃子
  • Publisher: 診断と治療社 東京
• [Book] 下垂体腺腫の原因遺伝子と視床下部・下垂体のクロストーク. 日本臨床分子形態学会編 病気の分子形態学 (2011)
  • Author(s): 松野彰
  • Publisher: 学際企画
• [Book] 日本臨床分子形態学会 編 病気の分子形態学 第2章 各論 Ⅻ 内分泌の疾患 Ⅻ-4下垂体細胞の分化、下垂体腺腫の原因遺伝子と視床下部・下垂体のクロストーク (2011)
  • Author(s): 松野彰
  • Publisher: 学際企画