Clarification of integrated pathophysiology of cortico-basal ganglia in dystonia and strategic treatment of deep brain stimulation
| Project/Area Number |
23592144
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
TAIRA Takaomi 東京女子医科大学, 医学部, 臨床教授 (30167481)
|
|---|
| Research Collaborator |
GOTO Shinichi
|
|---|
| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | ジストニア / 脳深部刺激 / 淡蒼球 / 視床 / 大脳基底核 / 大脳皮質 |
|---|
| Outline of Final Research Achievements |
In DBS for dystonias, whether the traditional GPi target is the optimal or not has not been clarified. In this research, we found that the more anterior part of GPi has no role for control of dystonia, and that the more posterior and lateral part at the level of midcommissural level has a more important role for control of dystonia. Furthermore, the target should be placed just above the lateral edge of the optic tract, rather than the middle part of the optic tract. For distal extremity symptoms, GPi DBS has less effect and Vo thalamus should be chosen as the treatment target. Although traditional concept of GPi DBS was to block the ansa lenticularis part of GPi, the lenticular fasciculus part of GPi and the area projected to the thalamus seemed more related with the effects of DBS treatment of dystonia.
|
Report
(5 results)
Research Products
(39 results)
-
-
[Journal Article] Consensus on guidelines for stereotactic neurosurgery for psychiatric disorders2014
Author(s)
Nuttin B, Wu H, Mayberg H, Hariz M, Gabriels L, Galert T, Merkel R, Kubu C, Vilela-Filho O, Matthews K, Taira T, et al
-
Journal Title
Journal of Neurology, Neurosurgery, and Psychiatry
Volume: 85
Issue: 9
Pages: 1003-1003
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] "術中支援統合画像環境SCOT(Smart Cyber Operating Theater) -機能・構造に注目した診断と治療を目指す未来予測手術-"2013
Author(s)
田村学†, 村垣善浩, 丸山隆志, 平孝臣, 林基弘, 小西良幸, 吉光喜太郎, 鈴木孝司, 生田聡子, 岡本淳, 仁木千晴, チエルノフミハイル, 岡田芳和, 伊関洋
-
Journal Title
映像情報Medical
Volume: 45
Pages: 590-596
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
