Therapeutic effect improvement by new boron neutron capture therapy with amino acid - BSH
| Project/Area Number |
23592146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FURUSE Motomasa 大阪医科大学, 医学部, 講師 (70340560)
IKEDA Naokado 大阪医科大学, 医学部, 非常勤講師 (50434775)
MATSUSHITA Yoko 大阪医科大学, 医学部, 助教 (70512094)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳腫瘍学 / 悪性神経膠腫 / 放射線治療 / ホウ素化合物 / 中性子捕捉療法 / 合成アミノ酸 / ドラッグデリバリーシステム |
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| Research Abstract |
Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive Boron-10 is irradiated with low energy thermal neutrons to produce alpha- particles inside one cell level. The L-amino acid transport system in tumor cells is enhanced compared with normal cells. We designed, synthesized and tested boron carrying unnatural amino-acid, ACBC-BSH, as boron drug for BNCT. Curative effect of ACBC-BSH groups was approximately equal to BPA. The reason is that we think that extracellular accumulations of ACBC-BSH indicating that the seemingly high tumor boron concentrations did not represent the true tumor cellular uptake. And we did not compete for the curative effect by using ACBC-BSH together in BPA and accepted meaningful duration of survival time. Difference in drug distribution at the cell level was regarded as the cause. This study suggested the possibility that ACBC-BSH became the drug to add curative effect to.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide.2014
Author(s)
Michiue H, Sakurai Y, Kondo N, Kitamatsu M, Bin F, Nakajima K, Hirota Y, Kawabata S, Nishiki T, Ohmori I, Tomizawa K, Miyatake S, Ono K, Matsui H.
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Journal Title
Biomaterials.
Volume: 35
Issue: 10
Pages: 3396-3405
DOI
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Peer Reviewed
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[Journal Article] Boron neutron capture therapy (BNCT) selectively destroys human clear cell sarcoma in mouse model.2013
Author(s)
Fujimoto T, Andoh T, Sudo T, Fujita I, Moritake H, Sμgimoto T, Sakuma T, Akisue T, Kawabata S, Kirihata M, Suzuki M, Sakurai Y, Ono K, Fukumori Y, Kurosaka M, Ichikawa H
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Journal Title
Appl Radiat Isot.
Volume: 73
Pages: 96-100
DOI
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Peer Reviewed
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[Journal Article] Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer.2012
Author(s)
Barth RF, Vicente MG, Harling OK, Kiger WS 3rd, Riley KJ, Binns PJ, Wagner FM, Suzuki M, Aihara T, Kato I, Kawabata S
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Journal Title
Radiat Oncol
Volume: 29
Issue: 1
Pages: 146-146
DOI
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Peer Reviewed
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[Presentation] 悪性脳腫瘍に対するホウ素中性子捕捉療法10年の経験と近未来像2012
Author(s)
川端信司,宮武伸一,平松亮,松下葉子,古瀬元雅,黒岩敏彦,鈴木実,田中浩基,櫻井良憲,切畑光統,小野公二
Organizer
第50回日本癌治療学会学術集会
Place of Presentation
京都
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[Presentation] Convection Enhanced Delivery (CED)が切り開く高分子ホウ素化合物のBNCTへの応用2012
Author(s)
川端信司,平松亮,宮田至朗,大西恭子,弘田祐己,横山邦夫,宮武伸一,黒岩敏彦,小野公二, Vicente MGH, Barth RF
Organizer
第50回日本癌治療学会学術集会
Place of Presentation
京都
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[Presentation] Background and trial design of the Phase I, open label, dose escalation study for safety and tolerability of boron neutron capture therapy (BNCT) using boronophenylalanine (SPM-011) / accelerator BNCT system (BNCT30) for the patients with recurrent malignant glioma2012
Author(s)
S. Kawabata, M Suzuki, S-I Miyatake, H Tanaka, Y Sakurai, K Uehara, T Hayashi, T Mitsumoto, Y Kikuchi, K Ono. , 2012/9/10-14
Organizer
The 15th International Congress on Neutron Capture Therapy
Place of Presentation
Tsukuba, JAPAN
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[Book] Boron Neutron Capture Therapy as a Treatment Modality for High‑Grade Gliomas.(Malignant Gliomas: RMR V3 I2; Series: Radiation Me dicine Rounds Volume 3 Issue 2, Arnab Chakravarti, Martin Fuss, Charles Thomas, Jr. (Eds.))2012
Author(s)
Rolf F. Barth, M. Graca H. Vicente, Otto K. Harling, Kent J. Riley, Pete r J. Binns, W. S. Kiger III, and Shi nji Kawabata
Publisher
demosmedical publisging
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