| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Cancer stem cells is a main cause of resistance of various cancer therapies. ABCG2 transporter, which is highly express in cancer stem cells, also transport excessive porphyrin to extra-cellular space. Therefore, controlling ABCG2 may enhance the effect of 5-ALA PDT and may control cancer stem cells.
In this study, we found that more than a half of porphyrin by produced by 5-ALA administration transported to extracellular space, and inhibition of ABCG2 transporter increased intra-cellular porphyrin and enhanced 5-ALA PDT effect. Furthermore, A172 glioma stem cell had a nature of 5-ALA PDT sensitivity, rather than resistance. These results indicated that 5-ALA PDT and/or combined with ABCG2 inhibitor may useful for controlling the cancer stem cells.
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