Development of an animal model in which neurogenic intermittent claudication is reproduced
| Project/Area Number |
23592151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
ATSUTA Yuji 旭川医科大学, 医学部, 講師 (90167924)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 腰部脊柱管狭窄症 / 間欠跛行 / 異所性興奮 / 馬尾血流 / 動物モデル |
|---|
| Research Abstract |
Neurogenic intermittent claudication is a characteristic symptom of lumbar spinal canal stenosis. In the present study, abnormal neuronal activities corresponding to intermittent claudication was reproduced to understand the pathophysiology. Using animal model of lumbar canal stenosis, abnormal sensory activities was increased by compression of cauda equina.This reaction was further increased by hypoxic condition, and decreased by hyper-oxygenic condition. The degree of reaction was related to oxygen supply to dorsal root ganglia. These results indicated that sensory nerve sensitization by chronic compression and dynamics of oxygen supply are major factors of neurogenic intermittent claudication.
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Report
(4 results)
Research Products
(10 results)
