| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
In the rat model of brachial plexus avulsion (BPA), pain-related behavior and the extent of glial activation was evaluated. The effect of local and general administration of anti-nerve growth factor receptor (p75 neurotrophin receptor [p75NTR]) antibodies was also evaluated in the BPA model. As a result, rats in the BPA group displayed significant mechanical hyperalgesia in the dermatome innervated by uninjured nerves both ipsilaterally and contra laterally. GFAP-immunoreactive astrocytes and Iba1-immunoreactive microglia were significantly activated on the ipsilateral side in the BPA group. And in the both rats group in which anti-p75NTR was locally or generally, mechanical hyperalgesia was significantly improved. Levels of GFAP-immunoreactive astrocytes and Iba1-immunoreactive microglia in the anti-p75NTR group were significantly reduced.
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