| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
In this study, we tested whether the inhibition of epidermal growth factor receptor (EGFR) regulates neurite extension in DRG neurons or Schwann cell (SC) proliferation in vitro and nerve regeneration in injured proneal nerves after end-to-side neurorrhaphy (ETS). The in vitro results showed that regeneration of neurites from explanted DRG neurons was not significantly accelerated by administration of EGFR inhibitor (EGFI). In contrast, the number of SCs was increased with EGFI treatment as shown by a viability assay. Rat peroneal nerve was cut and then ETS was performed 3 weeks later. EGFI was infused by osmotic pump at the injury site for 7 days. After the surgery, motor score was increased significantly at 2 weeks and the amount of myelin in the peroneal nerve was increased significantly at 4 weeks in the EGFI infusion group. These findings suggest that local administration of EGFI has the potential to increase functional recovery after peripheral nerve injury.
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