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Development of New Biological Therapy for Regeneration of Degenerated Interbvertebral Discs

Research Project

Project/Area Number 23592162
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionGifu University

Principal Investigator

MIYAMOTO Kei  岐阜大学, 医学(系)研究科(研究院), 准教授 (20313885)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Katsuji  岐阜大学, 大学院医学研究科, 教授 (90170969)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordscalpain / intervertebral disc / degeneration / anti aging / spine / yelolow ligament / anti-aging / yellow ligament / 椎間板 / アンチエイジング / 変性 / 炎症 / サイトカイン / カルパイン / 脊椎 / 3次元培養 / 3次元培養
Research Abstract

Influences of anti-inflammatory drugs and calpain on dintervertebral disc (IVD) degeneration were investigated in order to develop new biological treatment for degenerated IVD. Additionally, expression of calpain was examined in ossificication of yellow ligament (OYL) at thoracolumbar region associated with IVD degeneration. While Celecoxib and Indomethacin decreased production of inflammatory products in cultured bovine IVD cells with addition of interleukin-1, Celecoxib decreased expression of calpain in cultured medium. This suggested that use of calpain has some role in the anti-inflammatory function of Celecoxib for degenerated IVD. Expression of calpain in OYL was shown, suggesting that regulation of calpain can have a role in inhibition of development in OYL.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012 Other

All Journal Article (1 results) Presentation (5 results) Remarks (2 results)

  • [Journal Article] ヒト椎間板変性におけるカルパインの影響2012

    • Author(s)
      福田章二,宮本敬,鈴木毅一,井上俊之,喜久生健太,清水克時
    • Journal Title

      中部日本整形外科・災害外科学会雑誌

      Volume: Vol.55No.5 Pages: 94-94

    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢者における腰痛下肢痛の診断・説明・治療2014

    • Author(s)
      宮本敬
    • Organizer
      第9回老化と生活習慣病を考える会
    • Place of Presentation
      岐阜市
    • Year and Date
      2014-05-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Surgical treatment for infected spine using spinal instrumentation2014

    • Author(s)
      Kei Miyamoto
    • Organizer
      23rd Myanmar Orthopaedic Society Biennial Conference
    • Place of Presentation
      Myanmar
    • Year and Date
      2014-02-08
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト椎間板変性におけるカルパインの役割2013

    • Author(s)
      福田章二,宮本敬ら
    • Organizer
      第42日本脊椎脊髄病学会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト椎間板変性におけるカルパインのかかわり2012

    • Author(s)
      福田章二,宮本敬ら
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト椎間板におけるカルパインの局在と働き2012

    • Author(s)
      福田章二,宮本敬,井上俊之,鈴木毅一,喜久生健太,清水克時
    • Organizer
      第118回 中部整形外科災害外科学会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Research-status Report
  • [Remarks] 岐阜大学整形外科 基礎研究 脊椎脊髄研 究 ホームページ

    • URL

      http://hosp.gifu-u.ac.jp/seikei/

    • Related Report
      2013 Final Research Report
  • [Remarks] 岐阜大学整形外科 基礎研究 脊椎脊髄研究

    • URL

      http://hosp.gifu-u.ac.jp/seikei/kenkyu/kenkyu3.html

    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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