Development of New Biological Therapy for Regeneration of Degenerated Interbvertebral Discs
| Project/Area Number |
23592162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gifu University |
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Principal Investigator |
MIYAMOTO Kei 岐阜大学, 医学(系)研究科(研究院), 准教授 (20313885)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Katsuji 岐阜大学, 大学院医学研究科, 教授 (90170969)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | calpain / intervertebral disc / degeneration / anti aging / spine / yelolow ligament / anti-aging / yellow ligament / 椎間板 / アンチエイジング / 変性 / 炎症 / サイトカイン / カルパイン / 脊椎 / ３次元培養 / 3次元培養 |
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| Research Abstract |
Influences of anti-inflammatory drugs and calpain on dintervertebral disc (IVD) degeneration were investigated in order to develop new biological treatment for degenerated IVD. Additionally, expression of calpain was examined in ossificication of yellow ligament (OYL) at thoracolumbar region associated with IVD degeneration. While Celecoxib and Indomethacin decreased production of inflammatory products in cultured bovine IVD cells with addition of interleukin-1, Celecoxib decreased expression of calpain in cultured medium. This suggested that use of calpain has some role in the anti-inflammatory function of Celecoxib for degenerated IVD. Expression of calpain in OYL was shown, suggesting that regulation of calpain can have a role in inhibition of development in OYL.
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Report
(4 results)
Research Products
(8 results)
