Molecular mechanism in glia limitans during the repair of spinal cord injury
| Project/Area Number |
23592164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
YONEZAWA Tomoko 岡山大学, 医歯(薬)学総合研究科, 助教 (30304299)
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| Co-Investigator(Kenkyū-buntansha) |
NINOMIYA Yoshifumi 岡山大学, 大学院医歯薬学総合研究科, 教授 (70126241)
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| Research Collaborator |
HOTTA Akira 岡山大学, 大学院医歯薬学総合研究科, 大学 院生
INOMOTO Saori 岡山大学, 医学部保健学科, 4年生
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脊髄損傷 / インテグリン |
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| Research Abstract |
Primary mechanical spinal cord injury causes the secondary injury, which expands the size of initial injury and affects paralysis and motor function loss. We reported that the expression of alpha1 integrin transiently increased after brain injury. In this study, we hypothesized alpha1 integrin would play a role in spinal cord injury. The results suggested that the role of alpha1 integrin associated with inflammation of secondary spinal cord injury.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse2013
Author(s)
Demircan K, Yonezawa T, Takigawa T, Topcu V, Erdogan S, Ucar F, Armutcu F, Yigitoglu MR, Ninomiya Y, Hirohata S
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Journal Title
Neurosci Lett
Volume: 544
Pages: 25-30
DOI
Related Report
Peer Reviewed
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[Journal Article] Distribution of α(IV) collagen chains in the ocular anterior segments of adult mice2011
Author(s)
Saito K, Yonezawa T, Minaguchi J, Kurosaki M, Suetsugu S, Nakajima A, Nomoto H, Morizane Y, Sado Y, Sugimoto M, Kusachi S, Ninomiya Y
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Journal Title
Connect Tissue Res
Volume: 52(2)
Issue: 2
Pages: 147-56
DOI
Related Report
Peer Reviewed
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[Journal Article] Distribution of alpha(IV) collagen chains in the ocular anterior segments of adult mice.2011
Author(s)
Saito K, Yonezawa T, Minaguchi J, Kurosaki M, Suetsugu S, Nakajima A, Nomoto H, Morizane Y, Sado Y, Sugimoto M, Kusachi S, Ninomiya Y.
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Journal Title
Connective Tissue Research
Volume: 52
Pages: 147-156
Related Report
Peer Reviewed
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