Molecular mechanism in glia limitans during the repair of spinal cord injury

• Project/Area Number: 23592164
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: YONEZAWA Tomoko 岡山大学, 医歯(薬)学総合研究科, 助教 (30304299)
• Co-Investigator(Kenkyū-buntansha): NINOMIYA Yoshifumi 岡山大学, 大学院医歯薬学総合研究科, 教授 (70126241)
• Research Collaborator: HOTTA Akira 岡山大学, 大学院医歯薬学総合研究科, 大学 院生 ; INOMOTO Saori 岡山大学, 医学部保健学科, 4年生
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脊髄損傷 / インテグリン

Research Abstract

Primary mechanical spinal cord injury causes the secondary injury, which expands the size of initial injury and affects paralysis and motor function loss. We reported that the expression of alpha1 integrin transiently increased after brain injury. In this study, we hypothesized alpha1 integrin would play a role in spinal cord injury. The results suggested that the role of alpha1 integrin associated with inflammation of secondary spinal cord injury.

Research Products

• [Journal Article] Light and electron microscopic detection of inflammation-targeting liposomes encapsulating high-density colloidal gold in arthritic mice (2014)
  • Author(s): Maehara A, Nishida K, Furutani M, Matsumoto E, Ohtsuka A, Ninomiya Y, Oohashi T
  • Journal Title: Inflamm Res Volume: 63(2) Issue: 2 Pages: 139-47
  • DOI: 10.1007/s00011-013-0682-4
  • Peer Reviewed
• [Journal Article] ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse (2013)
  • Author(s): Demircan K, Yonezawa T, Takigawa T, Topcu V, Erdogan S, Ucar F, Armutcu F, Yigitoglu MR, Ninomiya Y, Hirohata S
  • Journal Title: Neurosci Lett Volume: 544 Pages: 25-30
  • DOI: 10.1016/j.neulet.2013.02.064
  • Peer Reviewed
• [Journal Article] Drosophila type XV/XVIII collagen mutants manifest integrin mediated mitochondrial dysfunction, which is improved by cyclosporin A and losartan (2013)
  • Author(s): Momota R, Narasaki M, Komiyama T, Naito I, Ninomiya Y, Ohtsuka A
  • Journal Title: Int J Biochem Cell Biol Volume: 45(5) Issue: 5 Pages: 1003-11
  • DOI: 10.1016/j.biocel.2013.02.001
  • Peer Reviewed
• [Journal Article] A new model of development of the mammalian ovary and follicles (2013)
  • Author(s): Hummitzsch K, Irving-Rodgers HF, Hatzirodos N, Bonner W, Sabatier L, Reinhardt DP, Sado Y, Ninomiya Y, Wilhelm D, Rodgers RJ
  • Journal Title: PLoS One Volume: 8(2) Issue: 2 Pages: e55578-e55578
  • DOI: 10.1371/journal.pone.0055578
  • Peer Reviewed
• [Journal Article] Differential expression of basement membrane type IV collagen α2 and α6 chains as a prognostic factor in patients with extrahepatic bile duct carcinoma (2013)
  • Author(s): Hirashima K, Iyama K, Baba Y, Honda Y, Sado Y, Ninomiya Y, Watanabe M, Takamori H, Beppu T, Baba H
  • Journal Title: J Surg Oncol Volume: 107(4) Issue: 4 Pages: 402-7
  • DOI: 10.1002/jso.23225
  • Peer Reviewed
• [Journal Article] Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brain stem and cerebellum (2011)
  • Author(s): Bekku Y, Saito M, Moser M, Fuchigami M, Maehara A, Nakayama M, Kusachi S, Ninomiya Y, Oohashi T
  • Journal Title: J Comp Neurol Volume: 520 Issue: 8 Pages: 1721-1736
  • DOI: 10.1002/cne.23009
  • Peer Reviewed
• [Journal Article] Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution (2011)
  • Author(s): Momota R, Naito I, Ninomiya Y, Ohtsuka A
  • Journal Title: Matrix Biol Volume: 30 Issue: 4 Pages: 258-266
  • DOI: 10.1016/j.matbio.2011.03.008
  • NAID: 120003386550
  • Peer Reviewed
• [Journal Article] Clonal overgrowth of esophageal smooth muscle cells in diffuse leiomyomatosis-Alport syndrome caused by partial deletion in COL4A5 and COL4A6 genes (2011)
  • Author(s): Oohashi T, Naito I, Ueki Y, Yamatsuji T, Permpoon R, Tanaka N, Naomoto Y, Ninomiya Y
  • Journal Title: Matrix Biol Volume: 30(1) Issue: 1 Pages: 3-8
  • DOI: 10.1016/j.matbio.2010.09.003
  • Peer Reviewed
• [Journal Article] Distribution of α(IV) collagen chains in the ocular anterior segments of adult mice (2011)
  • Author(s): Saito K, Yonezawa T, Minaguchi J, Kurosaki M, Suetsugu S, Nakajima A, Nomoto H, Morizane Y, Sado Y, Sugimoto M, Kusachi S, Ninomiya Y
  • Journal Title: Connect Tissue Res Volume: 52(2) Issue: 2 Pages: 147-56
  • DOI: 10.3109/03008207.2010.492062
  • Peer Reviewed
• [Journal Article] Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane (2011)
  • Author(s): Kinnunen AI, ら
  • Journal Title: J Biol Chem Volume: 286 Issue: 10 Pages: 7755-7764
  • DOI: 10.1074/jbc.m110.166132
  • Peer Reviewed
• [Journal Article] Distribution of alpha(IV) collagen chains in the ocular anterior segments of adult mice. (2011)
  • Author(s): Saito K, Yonezawa T, Minaguchi J, Kurosaki M, Suetsugu S, Nakajima A, Nomoto H, Morizane Y, Sado Y, Sugimoto M, Kusachi S, Ninomiya Y.
  • Journal Title: Connective Tissue Research Volume: 52 Pages: 147-156
  • Peer Reviewed
• [Presentation] 脊髄損傷におけるIV型コラーゲンα鎖の発現と分布の継時的変化 (2013)
  • Author(s): 米澤朋子
  • Organizer: 日本結合組織学会・マトリックス研究会
  • Place of Presentation: 和歌山県立医科大学
• [Presentation] 脊髄損傷におけるIV型コラーゲンα鎖の発現と分布の経時的変化 (2013)
  • Author(s): 米澤朋子、堀田輝、井本紗央里、髙垣和也、斎藤健司、佐渡義一、二宮善文
  • Organizer: 第45回日本結合組織学会学術大会、第60回マトリックス研究会合同学術大会
  • Place of Presentation: 和歌山県立医科大学
• [Presentation] アストロサイトのサイトカイン産生におけるIV型コラーゲンの役割 (2012)
  • Author(s): 堀田輝
  • Organizer: 日本結合組織学会・マトリックス研究会
  • Place of Presentation: 日本青年館ホテル
• [Presentation] The expression of interleukin-6 is attenuated by type IV collagen in cultured astrocytes (2012)
  • Author(s): 米澤朋子
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] The inhibitory role of an angiotensin II converting enzyme inhibitor on gelatinase activity in experimental abdominalaortic aneurysm (2012)
  • Author(s): 三好亨
  • Organizer: 日本血管生物医学会
  • Place of Presentation: あわぎんホール
• [Presentation] アストロサイトのサイトカイン産生におけるIV型コラーゲンの役割 (2012)
  • Author(s): 堀田 輝、米澤 朋子、二宮 善文
  • Organizer: 第43回日本結合組織学会学術大会・第59回マトリックス研究会大会 合同学術集会
  • Place of Presentation: 日本青年館ホテル
• [Presentation] アストロサイトのIL-6の産生はIV型コラーゲンによって抑制される (2012)
  • Author(s): 米澤 朋子、堀田 輝、二宮 善文
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] マウス眼におけるIV型コラーゲンα鎖の分布 (2011)
  • Author(s): 斎藤健司
  • Organizer: 日本結合組織学会・マトリックス研究会
  • Place of Presentation: 別府ビーコンプラザ
• [Presentation] アストロサイトのサイトカイン産生に対するIV型コラーゲンの作用 (2011)
  • Author(s): 米澤朋子、二宮善文
  • Organizer: 第43回日本結合組織学会学術大会、第58回マトリックス研究会大会、合同学術集会
  • Place of Presentation: 別府ビーコンプラザ
• [Book] 先天代謝異常症候群 (2012)
  • Author(s): 米澤朋子、二宮善文
  • Total Pages: 4
  • Publisher: 日本臨床
• [Book] 血管生物医学事典 (2011)
  • Author(s): 二宮善文
  • Total Pages: 2
  • Publisher: 朝倉書店
• [Book] 血管生物医学事典 (2011)
  • Author(s): 二宮善文、米澤朋子
  • Total Pages: 2
  • Publisher: 朝倉書店
• [Remarks]
  • URL: http://www.mbb-okayama.com/
• [Remarks]
  • URL: http://mbb-okayama.sakura.ne.jp/