The effect of non-noxious stimulation and repeated restraint stress on pain-related behavior in a nucleus pulpous applied rat model.

• Project/Area Number: 23592169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: Sekiguchi Miho 福島県立医科大学, 医学部, 准教授 (00381400)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Shinichi 公立大学法人福島県立医科大学, 医学部, 理事長兼学長 (80045773) ; KONNO Shinichi 公立大学法人福島県立医科大学, 医学部, 教授 (70254018)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: 慢性疼痛 / 疼痛関連行動 / ストレス / 腰椎疾患 / 疼痛閾値 / 腰椎椎間板ヘルニア / 神経再生 / 脳・神経 / 疼痛

Outline of Final Research Achievements

Both non-noxious stimulation and repeated restrain stress effect to last the reduction of mechanical withdrawal threshold in the nucleus polposus applied rats model. The stress markers did not change according to the non-noxious stimulation, while the repeated restrain stress influence the delayed cytokain expression and histological nerve tissue changes. These results might suggest that the relationship between the pain-related behavior and nerve recovery. Stress is one of the triggers for chronicity of pain and furthermore studies are needed to investigate an influence on nerve tissue and it’s an important proof for treatment strategy.

Research Products

• [Presentation] 整形外科医から発信する基礎的研究. (2014)
  • Author(s): 関口美穂
  • Organizer: 第13回横浜関節疾患研究会
  • Place of Presentation: 神奈川県
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] 運動器疾患の痛み－慢性疼痛とは？―. (2014)
  • Author(s): 関口美穂
  • Organizer: 福相整形懇話会
  • Place of Presentation: 福島県
  • Year and Date: 2014-04-24
  • Invited
• [Presentation] The effect of non-noxious stimulation in pain-related behavior compared with repeated restraint stress in an experimental nucleus pulposus applied rat model. (2013)
  • Author(s): Sekguchi M
  • Organizer: The 44 th NIPS international symposium and the 5th Asian Pain Symposium
  • Place of Presentation: 名古屋
• [Presentation] 慢性疼痛の病態―ベンチからベッドサイドへ－腰椎疾患モデルを用いたストレス不可と慢性化の影響について (2013)
  • Author(s): 関口美穂
  • Organizer: 第２８回日本整形外科学会基礎学術集会．
  • Place of Presentation: 千葉
• [Presentation] 腰痛とは？－腰椎疾患モデルを用いて－ (2013)
  • Author(s): 関口美穂
  • Organizer: 日本実験動物技術者協会東北支部講演会
  • Place of Presentation: 福島
  • Invited
• [Presentation] ラット髄核留置モデルにおける非侵害刺激の疼痛関連行動への影響 (2012)
  • Author(s): 関口美穂
  • Organizer: に本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋