The effect of non-noxious stimulation and repeated restraint stress on pain-related behavior in a nucleus pulpous applied rat model.
| Project/Area Number |
23592169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Sekiguchi Miho 福島県立医科大学, 医学部, 准教授 (00381400)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Shinichi 公立大学法人福島県立医科大学, 医学部, 理事長兼学長 (80045773)
KONNO Shinichi 公立大学法人福島県立医科大学, 医学部, 教授 (70254018)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 慢性疼痛 / 疼痛関連行動 / ストレス / 腰椎疾患 / 疼痛閾値 / 腰椎椎間板ヘルニア / 神経再生 / 脳・神経 / 疼痛 |
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| Outline of Final Research Achievements |
Both non-noxious stimulation and repeated restrain stress effect to last the reduction of mechanical withdrawal threshold in the nucleus polposus applied rats model. The stress markers did not change according to the non-noxious stimulation, while the repeated restrain stress influence the delayed cytokain expression and histological nerve tissue changes. These results might suggest that the relationship between the pain-related behavior and nerve recovery. Stress is one of the triggers for chronicity of pain and furthermore studies are needed to investigate an influence on nerve tissue and it’s an important proof for treatment strategy.
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Report
(6 results)
Research Products
(6 results)
