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The effect of non-noxious stimulation and repeated restraint stress on pain-related behavior in a nucleus pulpous applied rat model.

Research Project

Project/Area Number 23592169
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionFukushima Medical University

Principal Investigator

Sekiguchi Miho  福島県立医科大学, 医学部, 准教授 (00381400)

Co-Investigator(Kenkyū-buntansha) KIKUCHI Shinichi  公立大学法人福島県立医科大学, 医学部, 理事長兼学長 (80045773)
KONNO Shinichi  公立大学法人福島県立医科大学, 医学部, 教授 (70254018)
Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords慢性疼痛 / 疼痛関連行動 / ストレス / 腰椎疾患 / 疼痛閾値 / 腰椎椎間板ヘルニア / 神経再生 / 脳・神経 / 疼痛
Outline of Final Research Achievements

Both non-noxious stimulation and repeated restrain stress effect to last the reduction of mechanical withdrawal threshold in the nucleus polposus applied rats model. The stress markers did not change according to the non-noxious stimulation, while the repeated restrain stress influence the delayed cytokain expression and histological nerve tissue changes. These results might suggest that the relationship between the pain-related behavior and nerve recovery. Stress is one of the triggers for chronicity of pain and furthermore studies are needed to investigate an influence on nerve tissue and it’s an important proof for treatment strategy.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2014 2013 2012

All Presentation (6 results) (of which Invited: 3 results)

  • [Presentation] 整形外科医から発信する基礎的研究.2014

    • Author(s)
      関口美穂
    • Organizer
      第13回横浜関節疾患研究会
    • Place of Presentation
      神奈川県
    • Year and Date
      2014-07-10
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 運動器疾患の痛み-慢性疼痛とは?―.2014

    • Author(s)
      関口美穂
    • Organizer
      福相整形懇話会
    • Place of Presentation
      福島県
    • Year and Date
      2014-04-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The effect of non-noxious stimulation in pain-related behavior compared with repeated restraint stress in an experimental nucleus pulposus applied rat model.2013

    • Author(s)
      Sekguchi M
    • Organizer
      The 44 th NIPS international symposium and the 5th Asian Pain Symposium
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 慢性疼痛の病態―ベンチからベッドサイドへ-腰椎疾患モデルを用いたストレス不可と慢性化の影響について2013

    • Author(s)
      関口美穂
    • Organizer
      第28回日本整形外科学会基礎学術集会.
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Presentation] 腰痛とは?-腰椎疾患モデルを用いて-2013

    • Author(s)
      関口美穂
    • Organizer
      日本実験動物技術者協会東北支部講演会
    • Place of Presentation
      福島
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ラット髄核留置モデルにおける非侵害刺激の疼痛関連行動への影響2012

    • Author(s)
      関口美穂
    • Organizer
      に本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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