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Effect of intraneural decompression to peripheral nerve estimated by intraoperative nerve blood flow

Research Project

Project/Area Number 23592171
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka City University

Principal Investigator

OKADA Mitsuhiro  大阪市立大学, 医学(系)研究科(研究院), 講師 (40309571)

Co-Investigator(Kenkyū-buntansha) TAKAMATSU Kiyohito  大阪市立大学, 大学院医学研究科, 非常勤 講師 (30295688)
UEMURA Takuya  大阪市立大学, 大学院医学研究科, 病院講師 (10597321)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords筋・神経病学 / 末梢神経絞扼性障害 / 血管造影 / 整形外科学 / 電気生理学的検査 / 末梢神経血流評価
Research Abstract

The peripheral nerve has abundant vascularity inside. The vascularity decreases when the peripheral nerve is compressed. Angiography of the peripheral nerve was difficult by conventional imaging examinations. In this study, we succeeded in evaluating the vascularity of the peripheral nerve by use of indocyanine green fluorescence angiography.
The vascularity of the peripheral nerve was significantly improved by epineurotomy at the site of compression to the nerve, especially when the entrapment neuropathy was severe. The severity of the entrapment neuropathy causes fibrosis of the epineurium compressing the nerve itself. Our results suggested that epineurotomy decrease the pressure of nerve itself in case of treatment of severe entrapment neuropathy.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (60 results)

All 2014 2013 2012 2011

All Journal Article (23 results) (of which Peer Reviewed: 5 results) Presentation (35 results) Book (2 results)

  • [Journal Article] Resection interposition arthroplasty of calcaneonavicular coalition using a lateral supramalleolar adipofascial flap2013

    • Author(s)
      Okada M, Saito H
    • Journal Title

      J Pediatr Orthop B

      Volume: 22(3) Pages: 252-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] Solitary neurolymphomatosis of the brachial plexus mimicking benign nerve sheath tumour2013

    • Author(s)
      Okada M, Takamatsu K, Oebisu N, Nakamura H
    • Journal Title

      Br J Neurosurg

      Volume: 27(3) Pages: 386-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] 術中電気生理学的検査による手根管症候群重症例における正中神経の神経上膜剥離の必要性の検討(第1報)2013

    • Author(s)
      岡田充弘,池田幹則,高松聖仁,中村博亮
    • Journal Title

      日本手外科学会誌

      Volume: 3 Pages: 820-820

    • NAID

      40019715873

    • Related Report
      2013 Final Research Report
  • [Journal Article] A propeller flap based on the thoracoacromial artery for reconstruction of a skin defect in the cervical region2013

    • Author(s)
      Okada M, Ikeda M, Uemura T, Takada J, Nakamura H
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 66(5) Pages: 720-2

    • Related Report
      2013 Final Research Report
  • [Journal Article] Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system2013

    • Author(s)
      Ikeda M, Uemura T, Takamatsu K, Okada M, Kazuki K, Tabata Y, Ikada Y, Nakamura H
    • Journal Title

      J Biomed Mater Res A

    • Related Report
      2013 Final Research Report
  • [Journal Article] Radial artery perforator adiposal flap for coverage of the scarred median nerve2013

    • Author(s)
      Uemura T, Takamatsu K, Okada M, Ikeda M, Nakamura H
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 66(7) Pages: 1019-21

    • Related Report
      2013 Final Research Report
  • [Journal Article] 生体吸収性人工神経を用いたiPS cell- & bFGF drug-delivery systemの有効性2013

    • Author(s)
      上村卓也,高松聖仁,池田幹則,岡田充弘,香月憲一,田畑泰彦,筏義人,中村博亮
    • Journal Title

      末梢神経

      Volume: 24(1) Pages: 90-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] 神経再生iPS細胞と人工神経を用いた末梢神経再生治療開発2013

    • Author(s)
      上村卓也,高松聖仁,中村博亮
    • Journal Title

      Pharma Medica

      Volume: 31(4) Pages: 37-42

    • Related Report
      2013 Final Research Report
  • [Journal Article] Solitary neurolymphomatosis of the brachial plexus mimicking benign nerve sheath tumour: case report.2013

    • Author(s)
      Okada M, Takamatsu K, Oebisu N, Nakamura H.
    • Journal Title

      Br J Neurosurg

      Volume: 27 Issue: 3 Pages: 386-387

    • DOI

      10.3109/02688697.2012.737959

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 術中電気生理学的検査による手根管症候群重症例における正中神経の神経上膜剥離の必要性の検討(第1報)2013

    • Author(s)
      岡田 充弘, 池田 幹則, 高松 聖仁, 中村 博亮
    • Journal Title

      日本手外科学会雑誌

      Volume: 29 Pages: 837-839

    • NAID

      40019715873

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 手根管症候群重症例におけるICG蛍光法を用いた神経上膜剥離の効果の検討2013

    • Author(s)
      岡田 充弘, 上村卓也, 池田 幹則, 高松 聖仁, 中村 博亮
    • Journal Title

      末梢神経

      Volume: 24 Pages: 381-382

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Resection interposition arthroplasty of calcaneonavicular coalition using a lateral supramalleolar adipofascial flap: case report.2013

    • Author(s)
      Okada M, Saito H.
    • Journal Title

      J Pediatr Orthop B.

      Volume: 22 Issue: 3 Pages: 252-254

    • DOI

      10.1097/bpb.0b013e328353a1c1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A propeller flap based on the thoracoacromial artery for reconstruction of a skin defect in the cervical region: A case report.2013

    • Author(s)
      Okada M, Ikeda M, Uemura T, Takada J, Nakamura H.
    • Journal Title

      J Plast Reconstr Aesthet Surg.

      Volume: 66 Issue: 5 Pages: 720-722

    • DOI

      10.1016/j.bjps.2012.08.045

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic imaging and pathogenesis of the traumatic intratumoural haemorrhage of schwannoma causing acute high radial nerve palsy2012

    • Author(s)
      Okada M, Takada J, Ohsawa M, Nakamura H
    • Journal Title

      Br J Neurosurg

      Volume: 26(6) Pages: 907-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Transplantation of induced pluripotent stem cell-derived neurospheres for peripheral nerve repair2012

    • Author(s)
      Uemura T, Takamatsu K, Ikeda M, Okada M, Kazuki K, Ikada Y, Nakamura H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419(1) Pages: 130-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] 手根管症候群重症例における術中電気生理学的検査を用いた神経上膜切離の効果の検討(第一報)2012

    • Author(s)
      岡田充弘,上村卓也,池田幹則,高松聖仁,中村博亮
    • Journal Title

      末梢神経

      Volume: 23(2) Pages: 334-334

    • Related Report
      2013 Final Research Report
  • [Journal Article] 末梢神経再生へのiPS細胞の応用iPS細胞ハイブリッド型人工神経はマウスの末梢神経再生を促進する2012

    • Author(s)
      上村卓也,高松聖仁,池田幹則,岡田充弘,香月憲一,筏義人,中村博亮
    • Journal Title

      末梢神経

      Volume: 23(1) Pages: 55-62

    • NAID

      10030408356

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regenerative repair of bone defects with osteoinductive hydroxyapatite fabricated to match the defect and implanted with combined use of computer-aided design, computer-aided manufacturing, and computer-assisted surgery systems : a feasibility study in a canine model2012

    • Author(s)
      Yano K, Namikawa T, Uemura T, Hoshino M, Wakitani S, Takaoka K, Nakamura H
    • Journal Title

      J Orthop Sci

      Volume: 17(4) Pages: 484-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Diagnostic imaging and pathogenesis of the traumatic intratumoural haemorrhage of schwannoma causing acute high radial nerve palsy: case report.2012

    • Author(s)
      Okada M, Takada J, Ohsawa M, Nakamura H
    • Journal Title

      Br J Neurosurg.

      Volume: 26 Issue: 6 Pages: 907-908

    • DOI

      10.3109/02688697.2012.685784

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 手根管症候群重症例における術中電気生理学的検査を用いた神経上膜切離の効果の検討(第一報)2012

    • Author(s)
      岡田充弘、上村卓也、池田幹則、高松聖仁、中村博亮
    • Journal Title

      末梢神経

      Volume: 23 Pages: 334-334

    • Related Report
      2012 Research-status Report
  • [Journal Article] Excision of aberrant abductor pollicis longus tendon slips for decompression of de Quervain's disease2011

    • Author(s)
      Okada M, Kutz JE
    • Journal Title

      J Hand Surg(Er).

      Volume: 36(5) Pages: 379-382

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reversed lateral upper arm flap with a vascularised fragment of the humerus for reconstruction of ulna shaft fracture after resection of malignant tumour : A case report2011

    • Author(s)
      Okada M, Takamatsu K, Oebisu N, Nakamura H
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 64 Pages: 1373-1376

    • Related Report
      2013 Final Research Report
  • [Journal Article] A ganglion within the ulnar nerve and commucation with the distal radioulnar joint via an articular branch : case report2011

    • Author(s)
      Okada M, Sakaguchi K, Oebisu N, Takamatsu K, Nakamura H
    • Journal Title

      J Hand Surg Am

      Volume: 36(12) Pages: 2024-2026

    • Related Report
      2013 Final Research Report
  • [Presentation] 電気生理学的検査を用いた手根管症候群重症例における神経上膜切除の効果判定2014

    • Author(s)
      岡田充弘、中村博亮
    • Organizer
      第57回日本リハビリテーション医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 上部軟部組織欠損に対する有茎穿通枝皮弁を用いた再建2014

    • Author(s)
      岡田充弘、上村卓也、池田幹則、横井卓哉、中村博亮
    • Organizer
      第57回日本手外科学会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-04-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 手根管症候群重症例におけるICG蛍光法と電気生理学的検査を用いた神経上膜切除の効果判定2014

    • Author(s)
      岡田充弘、池田幹則、上村卓也、横井卓哉、中村博亮
    • Organizer
      第57回日本手外科学会学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-04-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 手根管症候群重症例におけるICG蛍光法と電気生理学的検査を用いた神経上膜切除の効果判定2014

    • Author(s)
      岡田充弘、池田幹則、上村卓也、横井卓哉、中村博亮
    • Organizer
      第57回日本手外科学会学術集会
    • Place of Presentation
      沖縄 沖縄コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電気生理学的検査を用いた手根管症候群重症例における神経上膜切除の効2014

    • Author(s)
      岡田充弘、中村博亮
    • Organizer
      第51回日本リハビリテーション医学会学術集会
    • Place of Presentation
      名古屋市 名古屋国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 有茎指動脈脂肪弁を用いた手指の慢性骨髄炎の治療2013

    • Author(s)
      岡田充弘、上村卓也、横井卓哉、中村博亮
    • Organizer
      第40回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      岩手
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 手根管症候群重症例におけるICG蛍光法を用いた神経上膜剥離の効果の検討2013

    • Author(s)
      岡田充弘、池田幹則、上村卓也、高松聖仁、中村博亮
    • Organizer
      第24回日本末梢神経学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2013-08-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Pedicled perforator flaps for upper limb reconstruction2013

    • Author(s)
      Okada M, Takamatsu K, Uemura T, Ikeda M, Nakamura H
    • Organizer
      FESSH 2013
    • Place of Presentation
      トルコ
    • Year and Date
      2013-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Combined medial pedis and medial plantar fasciocutaneous flaps for coverage of skin defects of multiple digits2013

    • Author(s)
      Okada M, Takamatsu K, Uemura T, Ikeda M, Nakamura H
    • Organizer
      FESSH 2013
    • Place of Presentation
      トルコ
    • Year and Date
      2013-05-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 内側足底動脈を用いた1血管茎2皮弁による多数指皮膚欠損の再建2013

    • Author(s)
      岡田充弘、斎藤英彦、香月憲一、中村博亮
    • Organizer
      第56回日本手外科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2013-04-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 長母指外転筋腱の解剖学的破格に着目した新しいde Quervain病の手術方法2013

    • Author(s)
      岡田充弘、J.E.Kutz、中村博亮
    • Organizer
      第56回日本手外科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2013-04-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 手根管症候群重症例におけるICG蛍光法を用いた神経上膜剥離の効果の検討2013

    • Author(s)
      岡田充弘、池田幹則、上村卓也、高松聖仁、中村博亮
    • Organizer
      第24回日本末梢神経学会学術集会
    • Place of Presentation
      新潟 朱鷺メッセ新潟コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 内側足底動脈を用いた1血管茎2皮弁による多数指皮膚欠損の再建2013

    • Author(s)
      岡田充弘、斎藤英彦、香月憲一、中村博亮
    • Organizer
      第56回日本手外科学会学術集会
    • Place of Presentation
      神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 長母指外転筋腱の解剖学的破格に着目した新しいde Cuervain病の手術方法2013

    • Author(s)
      岡田充弘、J.E.Kutz、中村博亮
    • Organizer
      第56回日本手外科学会学術集会
    • Place of Presentation
      神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Combined medial pedis and medial plantar fasciocutaneous flaps for coverage of skin defects of multiple digits2013

    • Author(s)
      Okada M, Uemura T, Ikeda M, Nakamura H.
    • Organizer
      FESSH 2013
    • Place of Presentation
      GLORIA CONVENTION CENTER BELEK-ANTALYA TURKEY
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pedicled perforator flaps for upper limb reconsturction2013

    • Author(s)
      Okada M, Takamatsu K, Uemura T, Ikeda M, Nakamura H.
    • Organizer
      FESSH 2013
    • Place of Presentation
      GLORIA CONVENTION CENTER BELEK-ANTALYA TURKEY
    • Related Report
      2013 Annual Research Report
  • [Presentation] 有茎指動脈脂肪弁を用いた手指の慢性骨髄炎の治療2013

    • Author(s)
      岡田充弘、上村卓也、横井卓哉、中村博亮
    • Organizer
      第40回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      岩手県 盛岡市文化ホールいわて県民情報交流センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胸肩峰動脈の穿通枝を用いたpropeller flapによる頸部再建の経験2012

    • Author(s)
      岡田充弘、上村卓也、中村博亮
    • Organizer
      第39回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2012-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 有茎穿通枝皮弁を用いた上肢再建の経験2012

    • Author(s)
      岡田充弘、高松聖仁、上村卓也、中村博亮
    • Organizer
      第39回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 内側足底動脈を用いた1血管茎2皮弁による多数指皮膚欠損の再建2012

    • Author(s)
      上山秀樹、岡田充弘、上村卓也、中村博亮
    • Organizer
      第39回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Intra-operative Release of the Epineurium in Severe Carpal Tunnel Syndrome2012

    • Author(s)
      Okada M, Uemura T, Ikeda M, Nakamura H
    • Organizer
      33th SICOT
    • Place of Presentation
      ドバイ
    • Year and Date
      2012-11-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 家兎を用いた骨形成蛋白(BMP-2)による血管柄付き骨移植の横径肥大促進2012

    • Author(s)
      岡田充弘、矢野公一、上村卓也、高岡邦夫、中村博亮
    • Organizer
      第38回日本マイクロサージャリー学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 中村博亮.手根管症候群重症例における術中電気生理学的検査を用いた神経上膜切離の効果の検討(第一報)2012

    • Author(s)
      岡田充弘、上村卓也、池田幹則、高松聖仁
    • Organizer
      第23回日本末梢神経学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] キーンベック病に対する橈骨遠位でのcore decompressionの治療成績2012

    • Author(s)
      岡田充弘、大井宏之、高松聖仁、上村卓也、中村博亮
    • Organizer
      第54回日本手外科学会学術集会サテライトシンポジウム
    • Place of Presentation
      青森
    • Year and Date
      2012-08-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 長母指外転筋腱の解剖学的変異に着目したde Quervain病の手術方法2012

    • Author(s)
      岡田充弘、J.E.Kutz、中村博亮
    • Organizer
      第25回日本臨床整形外科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 穿通枝皮弁を用いた上肢再建の経験2012

    • Author(s)
      岡田充弘、高松聖仁、池田幹則、中村博亮
    • Organizer
      第55回日本手外科学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 術中電気生理学的検査による手根管症候群重症例における手根管開放術の必要性の検討2012

    • Author(s)
      岡田充弘、高松聖仁、池田幹則、中村博亮
    • Organizer
      第55回日本手外科学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 術中電気生理学的検査による手根管症候群重症例における手根管開放術の必要性の検討2012

    • Author(s)
      岡田充弘、高松聖仁、池田幹則、中村博亮
    • Organizer
      日本手外科学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 穿通枝皮弁を用いた上肢再建の経験2012

    • Author(s)
      岡田充弘、高松聖仁、池田幹則、中村博亮
    • Organizer
      日本手外科学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 長母指外転筋腱の解剖学的変異に着目したde Quervain病の手術方法2012

    • Author(s)
      岡田充弘、J.E.Kutz、中村博亮
    • Organizer
      日本臨床整形外科学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 手根管症候群重症例における術中電気生理学的検査を用いた神経上膜切離の効果の検討(第一報)2012

    • Author(s)
      岡田充弘、上村卓也、池田幹則、高松聖仁、中村博亮
    • Organizer
      日本末梢神経学会学術集会
    • Place of Presentation
      九州大学
    • Related Report
      2012 Research-status Report
  • [Presentation] Intra-operative Release of the Epineurium in Severe Carpal Tunnel Syndrome2012

    • Author(s)
      Okada M, Uemura T, Ikeda M, Nakamura H.
    • Organizer
      SICOT
    • Place of Presentation
      アラブ首長国連邦
    • Related Report
      2012 Research-status Report
  • [Presentation] 有茎穿通枝皮弁を用いた上肢再建の経験2012

    • Author(s)
      岡田充弘、高松聖仁、上村卓也、中村博亮
    • Organizer
      日本マイクロサージャリー学会学術集会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 胸肩峰動脈の穿通枝を用いたpropeller flapによる頸部再建の経験2012

    • Author(s)
      岡田充弘、上村卓也、中村博亮
    • Organizer
      日本マイクロサージャリー学会学術集会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 術中電気生理学的検査による手根管症候群重症例における手根管開放術の必要性の検討2012

    • Author(s)
      岡田充弘
    • Organizer
      東日本手外科研究会
    • Place of Presentation
      盛岡
    • Related Report
      2011 Research-status Report
  • [Book] 指尖切断の治療2013

    • Author(s)
      岡田充弘、戸川大輔、熊谷研、柿木良介
    • Total Pages
      567
    • Publisher
      整形外科Surgical Technique
    • Related Report
      2013 Final Research Report
  • [Book] 整形外科 Surgical Technique2013

    • Author(s)
      岡田充弘、戸川大輔、熊谷研、柿木良介他
    • Total Pages
      120
    • Publisher
      メディカ出版
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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