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Neurotrophic factors for the treatment of low back pain

Research Project

Project/Area Number 23592175
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionChiba University (2014)
Toho University (2011-2013)

Principal Investigator

AOKI Yasuchika  千葉大学, 医学(系)研究科(研究院), 特任教授 (70584001)

Co-Investigator(Kenkyū-buntansha) OHTORI Seiji  千葉大学, 大学院医学研究院, 准教授 (40361430)
NAKAGAWA Koichi  東邦大学, 医学部, 教授 (30400823)
NAKAJIMA Arata  東邦大学, 医学部, 准教授 (60583995)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords椎間板 / 神経栄養因子 / 腰痛
Outline of Final Research Achievements

The protein levels of NGF and BDNF in discs from patients with disc herniation and hose from discs of patients with other lumbar degenerative disc diseases were examined. Nucleus pulposus tissue (or herniated disc tissue) was surgically removed and homogenized; protein levels were quantified using ELISAs for NGF and BDNF. Levels of NGF and BDNF in the discs were compared between 1) patients with disc herniation and those with other lumbar degenerative disc diseases, 2) patients with back pain and those with slight or no back pain, and 3) moderately degenerated discs and severely degenerated discs. Mean levels of NGF and BDNF in discs of patients were: NGF (herniation: 83.4; others: 64.8, pg/mg total protein); BDNF (herniation: 36.5: others 16.2, pg/mg total protein). Herniated discs showed significantly higher levels of NGF and BDNF (p<0.05). No significant differences were found between patients with and without back pain, or between moderately and severely degenerated discs.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?2014

    • Author(s)
      Aoki Y, Nakajima A, Ohtori S, Takahashi H, Watanabe F, Sonobe M, Terajima F, Saito M, Takahashi K, Toyone T, Watanabe A, Nakajima T, Takazawa M, Nakagawa K.
    • Journal Title

      Arthritis Research &Therapy

      Volume: 16-4 Issue: 4

    • DOI

      10.1186/ar4674

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phosphorylated neurofilament subunit NF-H becomes elevated in the cerebrospinal fluid of patients with acutely worsening symptoms of compression myelopathy: a pilot cross-sectional study in humans2014

    • Author(s)
      Takahashi H, Aoki Y, Nakajima A, Sonobe M, Terajima F, Saito M, Taniguchi S, Yamada M, Watanabe F, Furuya T, Koda M, Yamazaki M, Takahashi K, Nakagawa K.
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 21

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Discogenic Pain(椎間板性腰痛)およびModic Changeの基礎.2013

    • Author(s)
      青木保親、中川晃一、中島新、大鳥精司、高橋和久
    • Journal Title

      臨床スポーツ医学

      Volume: 30 Pages: 707-14

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] IκB kinase β inhibitor downregulates pain-related neuropeptide production in the sensory neurons innervating injured lumbar intervertebral discs in the dorsal root ganglia of rats.2013

    • Author(s)
      Orita S, Miyagi M, Kobori S, Gemba T, Ishikawa T, Inoue G, Toyone T, Aoki Y, Eguchi Y, Takahashi K, Ohtori S.
    • Journal Title

      Spine Journal

      Volume: 13 Issue: 3 Pages: 284-8

    • DOI

      10.1016/j.spinee.2013.01.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor-α-immunoreactive cells in nucleus pulposus in adolescent patients with lumbar disc herniation2013

    • Author(s)
      Seiji Ohtori
    • Journal Title

      Spine

      Volume: 38 Issue: 6 Pages: 459-62

    • DOI

      10.1097/brs.0b013e3182739cb4

    • NAID

      10031169965

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Nonspecific Low Back Pain Using a New Detailed Visual Analogue Scale for Patients2012

    • Author(s)
      Yasuchika Aoki
    • Journal Title

      Pain Research and Treatment

      Volume: 2012 Pages: 1-4

    • DOI

      10.1155/2012/680496

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Prospective Randomized Controlled Study Comparing Unilateral Pedicle Screw and One Cage Versus Bilateral Pedicle Screw and Two Cages in Transforaminal Lumbar Interbody Fusion for Degenerative Spondylolisthesis2012

    • Author(s)
      Yasuchika Aoki
    • Journal Title

      Journal of Neurosurgery Spine

      Volume: 17 Issue: 2 Pages: 153-59

    • DOI

      10.3171/2012.5.spine111044

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Increased levels of nerve growth factor and brain-derived neurotrophic factor in human herniated intervertebral discs.2014

    • Author(s)
      Aoki Y, Nakajima A, Watanabe F, Sonobe M, Terajima F, Takahashi H, Taniguchi S, Yamada M, Takahashi K, Ohtori S, Nakagawa K.
    • Organizer
      41st International Society for the study of the Lumbar Spine
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-06-03 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腰椎変性疾患患者の椎間板内NGF、BDNF発現量は症候性椎間板断裂、椎間板変性度、腰痛強度と関連しているか?

    • Author(s)
      青木保親、中川晃一、中島新、園部正人、柴田孝史、高橋宏、谷口慎治、大鳥精司、高橋和久
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳脊髄液中pNFHの発現は圧迫性脊髄症急性増悪時に上昇する

    • Author(s)
      高橋宏、青木保親、寺島史明、中島新、園部正人、斉藤雅彦、谷口慎治、山田学、古矢文雄、国府田正雄、高橋和久、中川晃一
    • Organizer
      第43回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Increased levels of nerve growth factor and brain-derived neurotrophic factor in human herniated intervertebral discs

    • Author(s)
      Aoki Y, Nakajima A, Watanabe F, Sonobe M, Terajima F, Takahashi H, Taniguchi S, Yamada M, Takahashi K, Ohtori S, Nakagawa K.
    • Organizer
      41st International Society for the Study of the Lumbar Spine
    • Place of Presentation
      Yonsei University (韓国ソウル市)
    • Related Report
      2013 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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