Development and evaluation of an injectable bone substitute with bioresorbability

• Project/Area Number: 23592179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: AE Keisuke 東京医科歯科大学, 医学部, 非常勤講師 (20376726)
• Co-Investigator(Kenkyū-buntansha): SOTOME Shinichi 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (20401391) ; OKAWA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 注入硬化型骨補填材 / ハイドロキシアパタイト・コラーゲン複合体 / リン酸カルシウムセメント / ハイドロキシアパタイトコラーゲン複合体 / 骨補填材 / 注入硬化型 / 生体吸収性

Research Abstract

The use of artificial bone grafts have increased because of its development. In general, bone graft surgery is relatively invasive. To realize less invasive implantation, some injectable artificial bone substitutes were developed. However their resorbabilities were very low and the implants were scarcely resorbed. The aim of this study was to develop and evaluate an injectable artificial bone substitute with bioresorbability and mehcanical strenght comparable to that of cancellous bone. The developed injectable bone substitute was consist of dense granule of hydroxyapatite/collagen composite (HAp/Col) and calcium phosphate cement. Compression test revealed taht the compression strength of the consolidated bone substitute was comparable to that of cancellous bone. Implantation experiment showed that resorption of the implant started mainly from the HAp/Col granules and the bone formation was occured at the resorption sites.

Research Products

• [Journal Article] How long should we follow patients with soft tissue sarcomas? (2014)
  • Author(s): Sawamura C, Matsumoto S, Shimoji T, Okawa A, Ae K
  • Journal Title: Clin Orthop Relat Res Volume: 472(3) Issue: 3 Pages: 842-8
  • DOI: 10.1007/s11999-013-3076-6
  • Peer Reviewed
• [Journal Article] After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate (2013)
  • Author(s): Yamada T, Yuasa M, Masaoka T, Taniyama T, Maehara H, Torigoe I, Yoshii T, Shinomiya K, Okawa A, Sotome S
  • Journal Title: Bone Volume: 57(2) Issue: 2 Pages: 343-54
  • DOI: 10.1016/j.bone.2013.08.028
  • Peer Reviewed
• [Journal Article] Massive bone reconstruction with heat-treated bone graft loaded autologous bone marrow-derived strom al cells andβ-tricalcium phosphate composites in canine models (2013)
  • Author(s): Koyanagi H, Ae K, Maehara H, Yuasa M, Masaoka T, Yamada T, Taniyama T, Saito M, Funauchi Y, Yoshii T, Okawa A, Sotome S
  • Journal Title: J Orthop Res Volume: 31(8) Issue: 8 Pages: 1308-16
  • DOI: 10.1002/jor.22368
  • Peer Reviewed
• [Journal Article] Porous/dense composite hydroxyapatite for anterior cervical discectomy and fusion (2013)
  • Author(s): Yoshii T, Yuasa M, Sotome S, Yamada T, Sakaki K, Hirai T, Taniyama T, Inose H, Kato T, Arai Y, Kawabata S, Tomizawa S, Enomoto M, Shinomiya K, Okawa A
  • Journal Title: Spine (Phila Pa 1976) Volume: 38(10) Issue: 10 Pages: 833-40
  • DOI: 10.1097/brs.0b013e3182801390
  • Peer Reviewed
• [Journal Article] Hybrid Grafting using Bone Marrow Aspirate combined with Porous beta-Tricalcium Phosphate and Trephine Bone for Lumbar Posterolateral Spinal Fusion : A Prospective, Comparative Study-Versus Local Bone Grafting- (2012)
  • Author(s): Yamada T, Yoshii T, Sotome S, Yuasa M, Kato T, Arai Y, Kawabata S, Tomizawa S, Sakaki K, Hirai T, Shinomiya K, Okawa A
  • Journal Title: Spine Volume: (In press) Issue: 3 Pages: 174-179
  • DOI: 10.1097/brs.0b013e3182269d64
  • Peer Reviewed
• [Presentation] Massive bone reconstruction with heat-treated bone graft loaded autologous bone marrow derived stromal cells and beta-tricalcium phosphate composites in canine models (2013)
  • Author(s): Koyanagi H, Ae K, Yuasa M, Masaoka T, Yamada T, Taniyama T, Yoshii T, Saito M, Okawa A, Sotome S
  • Organizer: 59th Annuial meeting of the orthopaedic research society
  • Place of Presentation: San Antonio, Texas
• [Presentation] 多孔質ハイドロキシアパタイト/コラーゲン複合体(HAp/Col)/リン酸カルシウムセメントhybrid人工骨の開発 (2013)
  • Author(s): 谷山崇、早乙女進一、山田剛史、正岡智和、韋雪濤、吉井俊貴、上坂優子、高山知士、平野昌弘、大川淳
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉
• [Presentation] 多孔質ハイドロキシアパタイト/コラーゲン複合体(HAp/Co1)/BMP-2ハイブリッドの骨軟骨欠損修復に対する有効性の検討 (2013)
  • Author(s): 谷山崇、早乙女進一、山田剛史、正岡智和、韋雪濤、吉井俊貴、上坂優子、高山知士、平野昌弘、大川淳
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉
• [Presentation] 新規骨補填材-多孔質ハイドロキシアパタイト・コラーゲン(Porous HAp/Col)の基礎と臨床 (2013)
  • Author(s): 早乙女進一
  • Organizer: 第46回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 東京
• [Presentation] 多孔質ハイドロキシアパタイト/コラーゲン複合体(HAp/Col)/リン酸カルシウムセメントhybrid人工骨の開発 (2013)
  • Author(s): 谷山 崇、早乙女 進一、山田 剛史、正岡 智和、韋 雪濤、吉井 俊貴、上坂 優子、高山 知士、平野 昌弘、大川 淳
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉県
• [Presentation] 多孔質ハイドロキシアパタイト・コラーゲン複合体(HAp/Col)の臨床応用 (2012)
  • Author(s): 早乙女進一、阿江啓介、大川淳、四宮謙一、平野昌弘、石突正文、森岡秀夫;松本誠一、中村孝志、阿部哲士、別府保男
  • Organizer: 第85回日本整形外科学会学術集会
  • Place of Presentation: 京都
• [Presentation] 多孔質ハイドロキシアパタイト・コラーゲン複合体(HAp/Col)移植による骨欠損治療後の骨形成 (2012)
  • Author(s): 正岡智和、早乙女進一、湯浅将人、山田剛史、谷山崇、吉井俊貴、上坂優子、平野昌弘、森田定雄、大川淳
  • Organizer: 力学特性の評価
  • Place of Presentation: 名古屋
• [Presentation] 多孔質ハイドロキシアパタイト・コラーゲン複合体（HAp/Col）の開発・・・基礎研究から臨床応用へ (2011)
  • Author(s): 早乙女進一、阿江啓介、若林良明、四宮謙一、大川 淳、平野昌弘、石突正文、森岡秀夫、松本誠一、中村孝志、阿部哲士、別府保男
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
• [Presentation] 骨移植治療の歴史と進歩 多孔質ハイドロキシアパタイト・コラーゲン複合体(HAp/Col)の開発と臨床応用 (2011)
  • Author(s): 早乙女進一、阿江啓介、若林良明、四宮謙一、平野昌弘、石突正文、森岡秀夫; 松本誠一、中村孝志、阿部哲士、別府保男
  • Organizer: 第84回日本整形外科学会学術集会
  • Place of Presentation: 東京
• [Book] 間葉系幹細胞を用いた骨再生 (2013)
  • Author(s): 早乙女進一
  • Total Pages: 486
  • Publisher: 血液フロンティア