| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
The use of artificial bone grafts have increased because of its development. In general, bone graft surgery is relatively invasive. To realize less invasive implantation, some injectable artificial bone substitutes were developed. However their resorbabilities were very low and the implants were scarcely resorbed. The aim of this study was to develop and evaluate an injectable artificial bone substitute with bioresorbability and mehcanical strenght comparable to that of cancellous bone. The developed injectable bone substitute was consist of dense granule of hydroxyapatite/collagen composite (HAp/Col) and calcium phosphate cement. Compression test revealed taht the compression strength of the consolidated bone substitute was comparable to that of cancellous bone. Implantation experiment showed that resorption of the implant started mainly from the HAp/Col granules and the bone formation was occured at the resorption sites.
|
