Development of oncolytic virotherapy using live attenuated poliovirus for human bone and soft tissue sarcomas.
Project/Area Number |
23592183
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Mie University |
Principal Investigator |
MATSUMINE Akihiko 三重大学, 医学(系)研究科(研究院), 准教授 (00335118)
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Co-Investigator(Kenkyū-buntansha) |
ASANUMA Kunihiro 三重大学, 大学院医学系研究科, 助教 (20378285)
MATSUBARA Takao 三重大学, 医学系研究科, 講師 (30422827)
NAKAMURA Tomoki 三重大学, 医学部附属病院, 助教 (50467362)
TOYODA Hidemi 三重大学, 大学院医学系研究科, 助教 (60525327)
KOMADA Yoshihiro 三重大学, 大学院医学系研究科, 教授 (80186791)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 弱毒化ポリオウイルス / 悪性骨軟部腫瘍 / 細胞融解療法 / CD155 / ポリオウイルス / ポリオ生ワクチン / 肉腫 / 細胞死 / アポトーシス / ポリオウイルスレセプター |
Research Abstract |
The poliovirus receptor CD155, is essential for poliovirus to induce cell-death in neural cells. Recently, CD155 has been shown to be selectively expressed on certain types of tumor cells originating from the neural crest. We first examined CD155 expression in sarcoma cell lines, and found the expression of CD155 in all of 10 sarcoma cell lines. Furthermore, we found that live-attenuated polio viruses (LAPV) induced apoptosis. In nude mice transplanted with HT1080, administration of live attenuated poliovirus caused growth suppression of the tumors. Next, the CD155 expression levels in 43 surgically resected soft tissue tumors were evaluated. The local recurrence free survival rate for patients with a high CD155 expression level was significantly poorer compared with that of patients with low CD155 expression levels. These results suggest that oncolytic therapy using a LAPV may represent a new option for the treatment of sarcomas.
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Report
(4 results)
Research Products
(147 results)
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[Journal Article] Clinical outcomes of Kyocera Modular Limb Salvage system after resection of bone sarcoma of the distal part of the femur : the Japanese Musculoskeletal Oncology Group study2013
Author(s)
Nakamura T, Matsumine A, Uchida A, Kawai A, Nishida Y, Kunisada T, Araki N, Sugiura H, Tomita M, Yokouchi M, Ueda T, Sudo A
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Journal Title
Int Orthop
Volume: 38
Issue: 4
Pages: 825-830
DOI
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Peer Reviewed
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[Journal Article] The thrombin inhibitor, argatroban, inhibits breast cancer metastasis to bone.2013
Author(s)
Asanuma K, Wakabayashi H, Okamoto T, Asanuma Y, Akita N, Yoshikawa T, Hayashi T, Matsumine A, Uchida A, Sudo A.
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Journal Title
Breast Cancer
Volume: 20(3)
Issue: 3
Pages: 241-246
DOI
NAID
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Peer Reviewed
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[Journal Article] Translational research of photodynamic therapy with acridine orange which targets cancer acidity2012
Author(s)
Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y.
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Journal Title
Curr Pharm Des
Volume: 18
Issue: 10
Pages: 1414-1420
DOI
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Peer Reviewed
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[Journal Article] Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus.2012
Author(s)
Atsumi S, Matsumine A, Toyoda H, Niimi R, Iino T, Nakamura T, Matsubara T, Asanuma K, Komada Y, Uchida A, Sudo A.
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Journal Title
Int J Oncol.
Volume: 41(3)
Issue: 3
Pages: 893-902
DOI
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Peer Reviewed
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[Journal Article] Japanese Musculoskeletal Oncology Group.Clinical outcomes of the KYOCERA Physio Hinge Total Knee System Type III after the resection of a bone and soft tissue tumor of the distal part of the femur2011
Author(s)
Matsumine A, Ueda T, Sugita T, Yazawa Y, Isu K, Kawai A, Abe S, Yakushiji T, Hiraga H, Sudo A, Uchida A
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Journal Title
J Surg Oncol
Volume: 103(3)
Issue: 3
Pages: 257-63
DOI
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Peer Reviewed
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[Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma2011
Author(s)
Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A
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Journal Title
Anticancer Res
Volume: 31
Pages: 4163-4168
URL
Related Report
Peer Reviewed
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[Journal Article] Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma.2011
Author(s)
Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T, Nakamura T, Asanuma K, Matsumine A, Sudo A.
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Journal Title
Anticancer Res.
Volume: 31(12)
Pages: 4163-8
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Peer Reviewed
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[Presentation] Clinical outcome of the KLS total Knee system after resection of bone sarcomas of the distal part of the femur: Japanese musculoskeletal oncology group (JMOG) study.2013
Author(s)
Nakamura T, Matsumine A, Uchida A, Kawai A, Nishida Y, Kunisada T, Araki N, Sugiura H, Ueda T, Sudo A.
Organizer
International Society of Limb Salvage 17th General Meeting
Place of Presentation
Bologna, Italy
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[Presentation] Analysis of tumor metastatic factor using low coagulation activity model in mice2012
Author(s)
Asanuma K, Matsumine A, Asanuma Y, Akita N, Yoshikawa T, Yoshida K, Matsubara T, Nakamura T, Okamoto T, Hayashi T, Uchida A, Sudo A
Organizer
13) Orthopaedic Research Society
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma2012
Author(s)
Satanaka H, Akeda K, Kusuzaki K, Tujii M, Iino T, Uemura T, Nakamura T, Matsubara T, Asanuma K, Matsumine A, Sudo A
Organizer
Orthopaedic Research Society
Place of Presentation
San Francisco, USA
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[Presentation] A Novel Oncolytic Virotherapy Using Live-attenuated Poliovirus for Soft Tissue Sarcoma.2012
Author(s)
S. Atsumi, A. Matsumine, Y. Asanuma, N. Akita, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, T. Okamoto, T. Hayashi, A. Uchida, A. Sudo.
Organizer
Orthopaedic Research Society
Place of Presentation
California
Related Report
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[Presentation] Analysis of tumor metastatic using low coagulation activity model in mice.2012
Author(s)
K. Asanuma, A. Matsumine, Y. Asanuma, N. Akita, T. Yoshikawa, K. Yoshida, T. Matsubara, T. Nakamura, T. Okamoto, Tatsuya Hayashi, A. Uchida, A. Sudo.
Organizer
Orthopaedic Research Society
Place of Presentation
California
Related Report
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[Presentation] Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma.2012
Author(s)
H. Satanaka, K. Akeda, K. Kusuzaki, M. Tujii, T. Iino, T. Uemura, T. Nakamura, T. Matsubara, K. Asanuma, A. Matsumine, A. Sudo.
Organizer
Orthopaedic Research Society
Place of Presentation
California
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[Book] Chapter VI : New concept of limb salvage surgery in musculoskeletal sarcomas with acridine orange therapy2012
Author(s)
Kusuzaki K, Hosogi S, Ashihara E, Matsubara T, Satonaka H, Nakamura T, Matsumine A, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y
Total Pages
179
Publisher
Nova Science Publishers
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