| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Human adipose tissue-derived regenerative cells (ADRCs) can be isolated easily and aseptically from unwanted subcutaneous fat without culturing. We investigated whether the transplantation of human adult ADRCs into skeletal muscle injury models promotes the repair of muscle tissues. This was done by locally injecting human ADRCs into the injured site after the laceration of the nude-rat tibialis anterior muscle. Phosphate-buffered saline (PBS) and bone marrow mononuclear cells (MNCs) were injected as negative control and positive control, respectively. After injury, recovery of the muscle strength was accelerated by the transplantation of ADRCs compared to the administration of PBS or MNCs. Moreover, the transplantation of ADRCs also enhanced angiogenesis and myogenesis, but the number of vascular or muscular cells labeled with the human cell-specific maker was limited in the injury site.
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