Target therapy for bone and soft tissue sarcoma
| Project/Area Number |
23592189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIE Ryouseke 香川大学, 医学部附属病院, 病院助教 (50645827)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 骨軟部腫瘍 / オートファジー / アポトーシス / mTOR / mTOR経路 / 軟部肉腫細胞 / 英語科学論文投稿 / MAPK経路 |
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| Outline of Final Research Achievements |
We examined target therapy of mTOR pathway using human bone and soft tissue sarcoma cell lines (MG63, Nara-H Cell). Our present study suggested that self protective mechanisms involving mTOR inhibitors in sarcoma cells are prevented by the inhibition of autophagy. The combination of an mTOR inhibitor and an autophagy inhibitor may offer effective treatment for sarcoma, as this combination effectively activates apoptotic pathways.
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Report
(5 results)
Research Products
(8 results)
