| Project/Area Number |
23592190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Ehime University |
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Principal Investigator |
MASHIMA Naohiko 愛媛大学, 医学(系)研究科(研究院), 准教授 (70274321)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Sengo 愛媛大学, 大学院理工学研究科, 准教授 (10304651)
IMAI Hiroshi 愛媛大学, 医学部附属病院, 講師 (20380222)
TAKEBA Jun 愛媛大学, 大学院医学系研究科, 講師 (80598681)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 人工関節 / チタン合金 / 骨芽細胞 / 力学試験 / 骨伝導 / 生体材料金属 / Bioactive |
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| Research Abstract |
Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects . One of these approaches is "GRAPE Technology," by which titanium and its alloys is grooved and thermally treated. The aim of this study was to investigate the osteoconductive effects of this technology when implanted using bone grafting in bony defects. Using Ti-15Zr-4Nb-4Ta alloy processed by this technique, we assessed the growth morphology, proliferative capacity, and differentiation activity of osteoblasts on the alloy. It was suggested that Ti-15Zr-4Nb-4Ta alloy processed employing GRAPE Technology, might enhance the growth rate and differentiation of osteoblasts to achieve favorable bone fixation .
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