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Development of new treatment for chondrosarcoma by targeting sarcoma stem cells

Research Project

Project/Area Number 23592192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyushu University

Principal Investigator

MATSUMOTO Yoshihiro  九州大学, 大学病院, 助教 (10346794)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Kazu  岐阜大学, 医学部附属病院, 講師 (40422711)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords軟骨肉腫 / 肉腫幹細胞 / 骨軟部腫瘍 / 薬剤耐性 / 癌幹細胞 / 悪性骨軟部腫瘍 / 腫瘍幹細胞
Outline of Final Research Achievements

Primary chondrosarcoma (CS) is the second most common primary malignant tumor of bone. Despite the continuous development and progress made in diagnostic techniques and auxiliary treatment, there is still no good treatment for CS at present. To develop new treatment for CS, we studied the oncogenesis of CS by focusing on the CS stem cells. We found that S100A4 and type I collgen were expressed in CS cell line that would have phenotype of CS stem cell by spheroid colony assay. We also established drug-resistance CS cell lines and the cell line expressed P-glycoprotein (Pgp), indicating that Pgp was able to be a candidate of molecular target of CS treatment.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways2015

    • Author(s)
      Nabeshima Y., Matsumoto Y., Iwamoto Y., et al
    • Journal Title

      British J Cancer

      Volume: NA Issue: 3 Pages: 1-9

    • DOI

      10.1038/bjc.2014.637

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Malignant peripheral nerve sheath tumors presenting as spinal dumbbell tumors: clinical outcomes and characteristic imaging features2014

    • Author(s)
      Yoshihiro Matsumoto ; Makoto Endo ; Katsumi Harimaya ; Mitsumasa Hayashida ; Toshio Doi ; Yukihide Iwamoto
    • Journal Title

      Eur Spine J

      Volume: NA Issue: 10 Pages: 1-7

    • DOI

      10.1007/s00586-014-3467-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dedifferentiated chondrosarcoma of the cervical spine: a case report2013

    • Author(s)
      Matsumoto Y, Takahashi Y, Harimaya K, Nakagawa T, Kawaguchi K, Okada S, Hayashida M, Doi T, Sakamoto A, Matsunobu T, Oda Y, Iwamoto Y
    • Journal Title

      World J Surg Oncol

      Volume: 2 Issue: 1 Pages: 32-32

    • DOI

      10.1186/1477-7819-11-32

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.2013

    • Author(s)
      Fujiwara-Okada Y, Matsumoto Y, Fukushi J, Setsu N, Matsuura S, Kamura S, Fujiwara T, Iida K, Hatano M, Nabeshima A, Yamada H, Ono M, Oda Y, Iwamoto Y.
    • Journal Title

      Br J Cancer

      Volume: 108 Issue: 4 Pages: 836-847

    • DOI

      10.1038/bjc.2012.579

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor.2013

    • Author(s)
      Iida K
    • Journal Title

      Cancer Cell International

      Volume: 13 Issue: 1 Pages: 21-21

    • DOI

      10.1186/1475-2867-13-21

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical outcome for patients with dedifferentiated chondrosarcoma: a report of 9 cases at a single institute.2012

    • Author(s)
      Yokota K, Sakamoto A, Matsumoto Y, Matsuda S, Harimaya K, Oda Y, Iwamoto Y
    • Journal Title

      J Orthop Surg Res.

      Volume: 7 Issue: 1 Pages: 38-38

    • DOI

      10.1186/1749-799x-7-38

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing Family Tumors.2012

    • Author(s)
      Li Y, Li X, Fan G, Fukushi J, Matsumoto Y, Iwamoto Y, Zhu Y.
    • Journal Title

      Cancer Lett.

      Volume: 320 Pages: 14-22

    • Related Report
      2011 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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