Development of an oncolytic virus targeting sarcoma as a biological agent
Project/Area Number |
23592203
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
Principal Investigator |
YAMAMURA Hisako 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 研究員 (50342994)
|
Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Katsuhito 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 研究員 (40211338)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 腫瘍溶解性ウイルス / カルポニン / 肉腫 / 中皮腫 / 遺伝子治療 / ヘルペスウイルス / 悪性中皮腫 |
Research Abstract |
d12.CALPfdeltaRR and d12.ODDdeltaRR were purified using a Vero designer cells which were carried out biological safety evaluation. Those two oncolytic HSV-1 viruses were tested their anti-tumor activity using malignant fibrous histiocytoma (MFH) which can be maintained in immuno-competent Fisher rats. We established 3D-spheroids cultures of human primary sarcoma cells, analysed RNA expression and tested their sensitivity to anti-tumor drugs.
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Report
(4 results)
Research Products
(21 results)