| Project/Area Number |
23592206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
JINNO Tetsuya 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (90343152)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Kunikazu 東京医科歯科大学, 医歯学総合研究科, 寄付講座准教授 (20323694)
MUNETA Takeshi 東京医科歯科大学, 医歯学総合研究科, 教授 (50190864)
SEKIYA Ichiro 東京医科歯科大学, 再生医療研究センター, 教授 (10345291)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 変形性関節症 / 関節軟骨 / メカニカルストレス / 卵巣摘除 / ovariectomy / treadmill running / osteoarthritis / cartilage / synovitis / 遺伝的背景 / 動物モデル / トレッドミル |
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| Research Abstract |
Osteoarthritis (OA) is considered to be a multifactorial disease with factors such as chronic inflammation, aging, menopause, obesity, genetic background, and mechanical stress. Estrogen depletion by ovariectomy (OVX) is reported to accelerate cartilage degradation in young female mice. Too much mechanical stress on articular cartilage, which may be caused by overweight, joint instability, or over-exercise, is reported to induce several catabolic factors for articular cartilage. These individual data clearly show that all these factors are involved in the pathogenesis of OA, however, orchestrated effects of these factors in OA progression are still unclear. To analyze the crosstalk between estrogen signal and mechanical stress on articular cartilage homeostasis, we analyzed the severity of cartilage damage after treadmill exercise in OVX mice. Here we reported that degree of articular cartilage degeneration induced by extensive treadmill exercise was greatly exacerbated by OVX.
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