| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
Biomarkers for knee osteoarthritis are quite important in estimating onset and progression of OA. To investigate the relationship between radiological knee OA changes and values of urinary CTX-II, one of candidate biomarkers of knee OA, in Japanese, we performed longitudinal population-based cohort study for three years. Urinary CTX-II was significantly higher in the OA progression group than that in the OA non-progression group in female. We further performed X-ray evaluation of knee OA at six years and found that uCTX-II values became significantly higher at three years than those at the start point in OA onset group of both gender. In addition, cases with higher values of mean uCTX-II had higher numbers of knee OA progression cases in both gender. These findings suggest that repeated measurements of uCTX-II could estimate the onset and progression of knee OA in Japanese.
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