| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We examined the effect of chewing on stress-induced bone loss in mice. SAMP8 was randomly divided into control, stress, and chewing groups. Mice in the stress and chewing groups were placed in a ventilated restraint tube for 60 minutes, twice a day for 4 weeks. Mice in the chewing group were allowed to chew a wooden stick during the experimental period. Bone response was evaluated using micro CT and biochemical markers. Exposure of SAMP8 mice to stress resulted in significant increase of the blood corticosterone and noradrenaline levels. The bone resorption was activated and the bone formation was suppressed. Trabecular bone volume was decreased in the stress group. Chewing under chronic stress prevented the increase in the blood corticosterone and noradrenaline levels, attenuated the reduced bone formation and increased bone resorption, improved the trabecular bone loss induced by chronic stress. These findings indicate that chewing can ameliorate stress-induced bone loss in mice.
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