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Catecholamine accelerates osteoblastic differentiation by enhancing bone -The effects of exercise on bone formation-

Research Project

Project/Area Number 23592227
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionOsaka City University

Principal Investigator

SUZUKI Akinobu  大阪市立大学, 医学(系)研究科(研究院), 講師 (00445016)

Co-Investigator(Kenkyū-buntansha) TAKAOKA Kunio  大阪市立大学, 大学院医学研究科, 名誉教授 (30112048)
HASHIMOTO Yusuke  大阪市立大学, 大学院医学研究科, 講師 (10382178)
UEMURA Takuya  大阪市立大学, 大学院医学研究科, 病院講師 (10597321)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords骨形成蛋白 / BMP / カテコラミン / 骨代謝 / 骨形成蛋白(BMP) / 骨形成 / 骨形成蛋白(BMP)
Research Abstract

Topical effects of a catecholamine on bone morphogenetic protein (BMP)-induced ectopic bone formation were investigated. Epinephrine enhanced bone induction by BMP-2. The mass of ossicles ectopically induced by BMP-2 was increased by the systemic addition of epinephrine. The expression level of alkaline phosphatase (ALP) in cells was consistently elevated by BMP-2 and was further elevated by the addition of epinephrine. The epinephrine-enhanced ALP elevation was specifically abolished by an antagonist to beta 2-adrenergic receptors and by a protein kinase A inhibitor. The luciferase activity of the Id1 gene was elevated by BMP-2 treatment and this activity was further enhanced by the addition of epinephrine. Epinephrine-enhanced luciferase activity was abolished by mutation of the cAMP-response element (CRE) sequence in the Id1 promoter, indicating that CRE-binding transcription proteins induced by epinephrine addition may act as enhancers of Smad-mediated BMP signaling.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

Research Products

(55 results)

All 2014 2013 2012 2011

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (30 results) Book (3 results)

  • [Journal Article] Prevalence and motion characteristics of degenerative cervical spondylolisthesis in the symptomatic adult2013

    • Author(s)
      Suzuki A, Daubs MD, Inoue H, Hayashi T, Aghdasi B, Montgomery SR, Ruangchainikom M, Hu X, Lee CJ, Wang CJ, Wang BJ, Nakamura H
    • Journal Title

      Spine

      Volume: 38(17)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of internal fixation for long bone metastasis prior to impending fracture : an experimental model2013

    • Author(s)
      Ibrahim M, Terai H, Yamada K, Suzuki A, Toyoda H, Nakamura H
    • Journal Title

      J Orthop Sci

      Volume: 18(4) Pages: 659-66

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiographic evaluation of postoperative bone regrowth after microscopic bilateral decompression via a unilateral approach for degenerative lumbar spondylolisthesis2013

    • Author(s)
      Dohzono S, Matsumura A, Terai H, Toyoda H, Suzuki A, Nakamura H
    • Journal Title

      J Neurosurg Spine

      Volume: 18(5) Pages: 472-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of initial conservative treatment interventions on the outcomes of patients with osteoporotic vertebral fractures2013

    • Author(s)
      Hoshino M, Tsujio T, Terai H, Namikawa T, Kato M, Matsumura A, Suzuki A, Takayama K, Takaoka K, Nakamura H
    • Journal Title

      Spine

      Volume: 38(11)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of diabetes associated with poor improvements in clinical outcomes after lumbar spine surgery2013

    • Author(s)
      Takahashi S, Suzuki A, Toyoda H, Terai H, Dohzono S, Yamada K, Matsumoto T, Yasuda H, Tsukiyama K, Shinohara Y, Ibrahim M, Nakamura H
    • Journal Title

      Spine

      Volume: 38(6) Pages: 516-22

    • NAID

      10031169974

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiographic evaluation of segmental motion of scoliotic wedging segment in degenerative lumbar scoliosis2013

    • Author(s)
      Yasuda H, Matsumura A, Terai H, Toyoda H, Suzuki A, Dozono S, Nakamura H
    • Journal Title

      J Spinal Disord Tech

      Volume: 26(7) Pages: 379-84

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] BMP-2 Adverse Reactions Treated With Human Dose Equivalent Dexamethasone in a Rodent Model of Soft-Tissue Inflammation2013

    • Author(s)
      Xiong C, Daubs MD, Montgomery SR, Aghdasi B, Inoue H, Tian H, Suzuki A, Tan Y, Hayashi T, Ruangchainikom M, Chai T, Corey M, Wang JC
    • Journal Title

      Spine

      Volume: 38(19) Pages: 1640-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anterior Opening Wedge Osteotomy of the Proximal Tibia for Genu Recurvatum Caused by Partial Proximal Tibial Epiphyseal Arrest2013

    • Author(s)
      Hara Y, Hashimoto Y, Takigami J, Yamasaki S and Nakamura H
    • Journal Title

      Journal of Case Reports in Medicine

      Volume: Vol2 (ID 235710)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 円板状半月手術後再手術に至った症例検討2013

    • Author(s)
      橋本祐介, 山崎真哉, 瀧上順誠, 寺井彰三郎, 中村博亮
    • Journal Title

      JOSKAS(1884-8842)

      Volume: 38巻1号 Pages: 172-173

    • NAID

      10031162468

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 若年者円板状半月損傷に対する半月形成と縫合併用手術後MRIの経時的変2013

    • Author(s)
      橋本祐介, 山崎真哉, 瀧上順誠, 寺井彰三郎, 中村博亮
    • Journal Title

      JOSKAS(1884-8842)

      Volume: 38巻1号 Pages: 170-171

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radial artery perforator adiposal flap for coverage of the scarred median nerve2013

    • Author(s)
      Uemura T, Takamatsu K, Okada M, Ikeda M, Nakamura H
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 66(7) Pages: 1019-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 末梢神経の再生医療生体吸収性人工神経を用いたiPS cell- & bFGF drug-delivery systemの有効性2013

    • Author(s)
      上村卓也, 高松聖仁, 池田幹則, 岡田充弘, 香月憲一, 田畑泰彦, 筏義人, 中村博亮
    • Journal Title

      末梢神経

      Volume: 24(1) Pages: 90-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radial artery perforator adiposal flap for coverage of the scarred median nerve.2013

    • Author(s)
      Uemura T, Takamatsu K, Okada M, Ikeda M, Nakamura H.
    • Journal Title

      J Plast Reconstr Aesthet Surg

      Volume: 66(7) Pages: 1019-1021

    • DOI

      10.1016/j.bjps.2013.01.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and motion characteristics of degenerative cervical spondylolisthesis in the symptomatic adult.2013

    • Author(s)
      Suzuki A, Daubs MD, Inoue H, Hayashi T, Aghdasi B, Montgomery SR, Ruangchainikom M, Hu X, Lee CJ, Wang CJ, Wang BJ, Nakamura H.
    • Journal Title

      Spine (Phila Pa 1976).

      Volume: 38(17) Pages: 1115-1120

    • DOI

      10.1097/brs.0b013e31829b1487

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of internal fixation for long bone metastasis prior to impending fracture: an experimental model.2013

    • Author(s)
      Ibrahim M, Terai H, Yamada K, Suzuki A, Toyoda H, Nakamura H.
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 18(4) Pages: 659-666

    • DOI

      10.1007/s00776-013-0380-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiographic evaluation of postoperative bone regrowth after microscopic bilateral decompression via a unilateral approach for degenerative lumbar spondylolisthesis.2013

    • Author(s)
      Dohzono S, Matsumura A, Terai H, Toyoda H, Suzuki A, Nakamura H.
    • Journal Title

      J Neurosurg Spine.

      Volume: 18(5) Pages: 472-478

    • DOI

      10.3171/2013.2.spine12633

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of initial conservative treatment interventions on the outcomes of patients with osteoporotic vertebral fractures.2013

    • Author(s)
      Hoshino M, Tsujio T, Terai H, Namikawa T, Kato M, Matsumura A, Suzuki A, Takayama K, Takaoka K, Nakamura H.
    • Journal Title

      Spine (Phila Pa 1976).

      Volume: 38(11) Pages: 641-648

    • DOI

      10.1097/brs.0b013e31828ced9d

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of diabetes associated with poor improvements in clinical outcomes after lumbar spine surgery.2013

    • Author(s)
      Takahashi S, Suzuki A, Toyoda H, Terai H, Dohzono S, Yamada K, Matsumoto T, Yasuda H, Tsukiyama K, Shinohara Y, Ibrahim M, Nakamura H.
    • Journal Title

      Spine (Phila Pa 1976).

      Volume: 38(6) Pages: 516-522

    • DOI

      10.1097/brs.0b013e318273583a

    • NAID

      10031169974

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiographic evaluation of segmental motion of scoliotic wedging segment in degenerative lumbar scoliosis.2013

    • Author(s)
      Yasuda H, Matsumura A, Terai H, Toyoda H, Suzuki A, Dozono S, Nakamura H.
    • Journal Title

      J Spinal Disord Tech.

      Volume: 26(7) Pages: 379-384

    • DOI

      10.1097/bsd.0b013e31824a4129

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of induced pluripotent stem cell-derived neurospheres for peripheral nerve repair.2012

    • Author(s)
      Uemura T, Takamatsu K, Ikeda M, Okada M, Kazuki K, Ikada Y, Nakamura H
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 130-135

    • DOI

      10.1016/j.bbrc.2012.01.154

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regenerative Repair of Bone Defect with Osteoinductive Hydroxyapatite Fabricated to Match the Defect and Implanted with Combined Use of Computer-aided Design, Computer-aided Manufacturing, and Computer-assisted Surgery Systems : A Feasibility Study in a Canine Model2012

    • Author(s)
      Koichi Yano, Takashi Namikawa, Takuya Uemura, Masatoshi Hoshino, Shigeyuki Wakitani, Kunio Takaoka, Hiroaki Nakamura
    • Journal Title

      J Orthop Sci

      Volume: 17(In press) Pages: 484-489

    • DOI

      10.1007/s00776-012-0235-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein-2 retained in synthetic polymer/β-tricalcium phosphate composite promotes hypertrophy of a vascularized long bone graft in rabbits.2011

    • Author(s)
      Okada M, Yano K, Namikawa T, Uemura T, Hoshino M, Kazuki K, Takaoka K, Nakamura H
    • Journal Title

      Plastic and Reconstructive Surgery

      Volume: 127 Pages: 98-106

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Magnetic Resonance Classification System of Cervical Intervertebral Disc Degeneration–Its Validity and Meaning2013

    • Author(s)
      Suzuki A, Daubs MD, Hayashi T, Ruangchainikom M, Xiong C, Scott TP, Phan K, Wang JC
    • Organizer
      第41回Cervical Spine Research Society
    • Related Report
      2013 Final Research Report
  • [Presentation] 日本ジュニアエリートテニス選手の世代別障害発生率の検討2013

    • Author(s)
      橋本祐介, 米谷泰一, 奥平修三, 平松久仁彦, 中田研
    • Organizer
      第23回日本臨床スポーツ医学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 若年性外側完全円板状半月に対する半月術後離断性骨軟骨炎発生率の検討2013

    • Author(s)
      橋本祐介, 山崎真哉, 瀧上順誠, 寺井彰三郎, 金田国一, 富原朋弘, 中村博亮
    • Organizer
      第23回日本臨床スポーツ医学会
    • Related Report
      2013 Final Research Report
  • [Presentation] iPS細胞ハイブリッド型人工神経による末梢神経再生2013

    • Author(s)
      上村卓也、高松聖仁、池田幹則、岡田充弘、田畑泰彦、筏義人、中村博亮
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system2013

    • Author(s)
      Uemura T, Takamatsu K, Ikeda M, Okada M, Kazuki K, Nakamura H
    • Organizer
      第68回American Society For Surgery Of The Hand
    • Related Report
      2013 Final Research Report
  • [Presentation] Radial artery perforator adiposal flap for the treatment of recurrent adhesion neuropathy of the median nerve2013

    • Author(s)
      Uemura T, Takamatsu K, Okada M, Ikeda M, Kazuki K, Nakamura H
    • Organizer
      第68回American Society For Surgery Of The Hand
    • Related Report
      2013 Final Research Report
  • [Presentation] 自家神経移植に匹敵する人工神経の開発iPS細胞とFGF-DDSを導入した新規ハイブリッド型人工神経2013

    • Author(s)
      上村卓也、高松聖仁、池田幹則、岡田充弘、田畑泰彦、筏義人、香月憲一、中村博亮
    • Organizer
      第40回日本マイクロサージャリー学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] 若年性外側円板状半月に対する半月術後離断性骨軟骨炎発生率の検討2013

    • Author(s)
      橋本祐介, 瀧上順誠, 山崎真哉, 寺井彰三郎, 金田国一, 富原朋弘, 島田永和, 中村博亮
    • Organizer
      第38回日本整形スポーツ医学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 二重束前十字靱帯再建術後MRI評価と前方不安定性の関係2013

    • Author(s)
      橋本祐介, 山崎真哉, 瀧上順誠, 寺井彰三郎, 中村博亮
    • Organizer
      第38回日本整形スポーツ医学会
    • Related Report
      2013 Final Research Report
  • [Presentation] iPS細胞ハイブリッド型人工神経による末梢神経の再生医療-マウス坐骨神経欠損モデルにおける長期成績と安全性について-2013

    • Author(s)
      上村卓也、高松聖仁、池田幹則、岡田充弘、横井卓哉、香月憲一、筏義人、中村博亮
    • Organizer
      第24回日本末梢神経学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical Outcomes of Microsurgical Bilateral Decompression via Unilateral Approach with Midline Spinous Process Splitting for Lumbar Spinal Stenosis–Minimum of 2 years Follow-up–2013

    • Author(s)
      Suzuki A, Terai H, Toyoda H, Takahashi Y, Nakamura H
    • Organizer
      第13回The Pacific and Asian Society of the Minimally Invasive Spine Surgery
    • Related Report
      2013 Final Research Report
  • [Presentation] 円板状半月形成術後のMRIを用いた半月形態と内部変化の検討2013

    • Author(s)
      橋本祐介, 瀧上順誠, 寺井彰三郎, 中村博亮
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 二重束前十字靱帯再建術後MRI評価と不安定性の関係2013

    • Author(s)
      橋本祐介, 山崎真哉, 瀧上順誠, 寺井彰三郎, 中村博亮
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Related Report
      2013 Final Research Report
  • [Presentation] Improvement of peripheral nerve regeneration by tissue-engineered nerve conduits combined with induced pluripotent stem cell technology2013

    • Author(s)
      Uemura T, Takamatsu K, Ikeda M, Okada M, Kazuki K, Nakamura H
    • Organizer
      第18回Federation of European Societes for Surgery of the Hand
    • Related Report
      2013 Final Research Report
  • [Presentation] 正中神経剥離後に対する橈骨動脈穿通枝脂肪弁の使用経験2013

    • Author(s)
      上村卓也、高松聖仁、岡田充弘、池田幹則、中村博亮
    • Organizer
      第86回日本整形外科学会学術集会
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 円板状半月形成術後のMRIを用いた半月形態と内部変化の検討2013

    • Author(s)
      橋本祐介, 山崎真哉, 瀧上順誠, 寺井彰三郎, 中村博亮
    • Organizer
      第85回日本整形外科学会学術集会
    • Related Report
      2013 Final Research Report
  • [Presentation] Incidence of disc degeneration of the thoracic spine and its effect on the segmental motion and spinal canal in symptomatic patients2013

    • Author(s)
      Suzuki A, Daubs MD, Hayashi T, Aghdasi B, Montgomery SR, Phan K, Scott TP, Nakamura H, Wang JC
    • Organizer
      第40回International Society for the Study of Lumbar Spine
    • Related Report
      2013 Final Research Report
  • [Presentation] Wang JC. Prevalence and Motion Characteristics of Degenerative Cervical Spondylolisthesis in Symptomatic Adult2013

    • Author(s)
      Suzuki A, Inoue H, Hayashi T, Nakamura H, Daubs MD
    • Organizer
      第42回日本脊椎脊髄病学会
    • Related Report
      2013 Final Research Report
  • [Presentation] Incidence of disc degeneration of the thoracic spine and its effect on the segmental motion and spinal canal in symptomatic patients2013

    • Author(s)
      Suzuki A, Hayashi T, Nakamura H, Daubs MD, Wang JC
    • Organizer
      第42回日本脊椎脊髄病学会
    • Related Report
      2013 Final Research Report
  • [Presentation] 正中神経剥離後に対する橈骨動脈穿通枝脂肪弁の有用性2013

    • Author(s)
      上村卓也、高松聖仁、岡田充弘、池田幹則、中村博亮
    • Organizer
      第56回日本手外科学会学術集会
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 二重束前十字靱帯再建術後MRI評価と不安定性の関係2013

    • Author(s)
      橋本祐介, 瀧上順誠, 山崎真哉, 中村博亮
    • Organizer
      第120回中部日本整形外科災害外科学会
    • Related Report
      2013 Final Research Report
  • [Presentation] Transplantation of Induced Pluripotent Stem Cell-derived Neurospheres for Peripheral Nerve Repair2013

    • Author(s)
      Uemura T, Takamatsu K, Ikeda M, Okada M, Nakamura H
    • Organizer
      2013 American Society for Peripheral Nerve
    • Related Report
      2013 Final Research Report
  • [Presentation] Prevalence and Motion Characteristics of Degenerative Cervical Spondylolisthesis in Symptomatic Adults2013

    • Author(s)
      Suzuki A, Inoue H, Hayashi T, Nakamura H, Daubs MD, Wang JC
    • Organizer
      第42回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      宜野湾市 沖縄コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] Incidence of disc degeneration of the thoracic spine and its effect on the segmental motion and spinal canal in symptomatic patients2013

    • Author(s)
      Suzuki A, Hayashi T, Nakamura H, Daubs MD, Wang JC
    • Organizer
      第42回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      宜野湾市 沖縄コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] Incidence of disc degeneration of the thoracic spine and its effect on the segmental motion and spinal canal in symptomatic patients2013

    • Author(s)
      Suzuki A, Daubs MD, Hayashi T, Aghdasi B, Montgomery SR, Phan K, Scott TP, Nakamura H, Wang JC
    • Organizer
      International Society for the Study of Lumbar Spine 2013
    • Place of Presentation
      アメリカ、Scottsdale, Fairmont Scottsdale Princess
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical Outcomes of Microsurgical Bilateral Decompression via Unilateral Approach with Midline Spinous Process Splitting2013

    • Author(s)
      Suzuki A, Terai H, Toyoda H, Takahashi Y, Nakamura H
    • Organizer
      The Pacific and Asian Society of the Minimally Invasive Spine Surgery 2013
    • Place of Presentation
      日本、宮崎市、PHOENIX SEAGAIA RESORT
    • Related Report
      2013 Annual Research Report
  • [Presentation] Magnetic Resonance Classification System of Cervical Intervertebral Disc Degeneration; Its Validity and Meaning2013

    • Author(s)
      Suzuki A, Daubs MD, Hayashi T, Ruangchainikom M, Xiong C, Scott TP, Phan K, Wang JC
    • Organizer
      Cervical Spine Research Society 2013
    • Place of Presentation
      アメリカ、Los Angelees, Hyatt Regency Century Plaza
    • Related Report
      2013 Annual Research Report
  • [Presentation] iPS細胞ハイブリッド型人工神経による末梢神経の再生医療 -マウス坐骨神経欠損モデルにおける長期成績と安全性について-2013

    • Author(s)
      上村卓也、高松聖仁、池田幹則、岡田充弘、横井卓哉、香月憲一、筏義人、中村博亮
    • Organizer
      第24回日本末梢神経学会
    • Place of Presentation
      新潟市 朱鷺メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自家神経移植に匹敵する人工神経の開発 iPS細胞とFGF-DDSを導入した新規ハイブリッド型人工神経2013

    • Author(s)
      上村卓也、高松聖仁、池田幹則、岡田充弘、田畑泰彦、筏義人、香月憲一、中村博亮
    • Organizer
      第40回日本マイクロサージャリー学会
    • Place of Presentation
      盛岡市 盛岡市民文化ホール(マリオス) いわて県民情報交流センター(アイーナ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway2012

    • Author(s)
      Uemura T, Ohta Y, Nakao Y, Manaka T, Nakamura H, Takaoka K
    • Organizer
      SICOT2012
    • Place of Presentation
      Dubai, United Arab Emirates, Dubai World Trade Centre
    • Related Report
      2012 Research-status Report
  • [Book] ジャンパー膝.今日の治療指針2014

    • Author(s)
      橋本祐介
    • Related Report
      2013 Final Research Report
  • [Book] 【整形外科領域と再生医療】神経再生iPS細胞と人工神経を用いた末梢神経再生治療開発2013

    • Author(s)
      上村卓也, 高松聖仁, 中村博亮
    • Publisher
      Pharma Medica (31(4))
    • Related Report
      2013 Final Research Report
  • [Book] メディカルレビュー社2013

    • Author(s)
      上村 卓也, 高松 聖仁, 中村 博亮
    • Total Pages
      174
    • Publisher
      Pharma Medica
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-04   Modified: 2019-07-29  

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