Investigation of gastrectomy-induced bone pathology and treatment: an approach from stomach-liver-bone axis
Project/Area Number |
23592229
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Wakayama Medical University |
Principal Investigator |
UEDA Kazuki 和歌山県立医科大学, 医学部, 博士研究員 (50405437)
|
Co-Investigator(Kenkyū-buntansha) |
UEYAMA Takashi 和歌山県立医科大学, 医学部・解剖学第一, 准教授 (50264875)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | Bone histomorphometry / parietal cells / stomach / transcriptosome / 胃切除後骨障害 / 肝臓 / 抗酸化ストレス / プロトンポンプ / 骨形態計測 / Microarray解析 / Network解析 / Proteosome解析 |
Research Abstract |
Using a gastrectomy (GX) rat model, we showed that GX induced high turnover of bone with hyperosteoidosis, prominent increase of mineralization and increased mRNA expression of both osteoclast-derived tartrate-resistant acid phosphatase 5b and osteocalcin. The increased 1, 25(OH)2D3 level and unchanged PTH and calcitonin levels suggested that conventional bone and Ca metabolic pathways were not involved or changed in compensation. Thus, GX-induced bone pathology was different from a typical osteomalacia. Gene expression profiles through microarray analysis and data mining using Ingenuity Pathway Analysis indicated that 612 genes were up-regulated and 1,097 genes were down-regulated in the GX bone. Network analysis indicated 9 genes were hubs connected with tissue development and immunological diseases. These results suggest that chronic systemic inflammation might underlie the GX-induced pathological changes in bone.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Nrf2-induceding anti-oxidation stress response in the liver - New beneficial effect of Lansoprazole2014
Author(s)
Yamashita Y, Ueyama T, Nishi T, Yamamoto Y, Kawakoshi A, Sunami S, Iguchi M, Tamai H, Ueda K, Ito T, Tsuruo Y, Ichinose M
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Journal Title
PLoS ONE
Volume: 9(5)
Issue: 5
Pages: e97419-e97419
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serological and histological indices of hepatocellular carcinoma and tumor volume doubling time.2013
Author(s)
Shingaki N, Tamai H, Mori Y, Moribata K, Enomoto S, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M
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Journal Title
Mol Clin Oncol
Volume: 1 (6)
Pages: 977-981
Related Report
Peer Reviewed
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[Journal Article] Usefulness of continuous suction mouthpiece during esophagogastroduodenoscopy: A single-center, prospective, randomized study.2013
Author(s)
Maekita T, Kato J, Nakatani Y, Enomoto S, Takano E, Tsuji M, Nakaya T, Moribata K, Muraki Y, Shingaki N, Niwa T, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ichinose M.
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Journal Title
World J Gastrointest Endosc
Volume: 16 (5)
Issue: 10
Pages: 508-513
DOI
Related Report
Peer Reviewed
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[Journal Article] Usefulness of a continuous suction mouthpiece during percutaneous endoscopic gastrostomy: a single-center, prospective, randomized study.2013
Author(s)
Maekita T, Kato J, Nakatani Y, Enomoto S, Kayama T, Tsuji M, Nakaya T, Muraki Y, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ichinose M.
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Journal Title
Dig Endosc
Volume: 25(5)
Issue: 5
Pages: 496-501
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis2013
Author(s)
Yoshida T, Kato J, Maekita T, Yamashita S, Enomoto S, Ando T, Niwa T, Deguchi H, Ueda K, Inoue I, Iguchi M, Tamai H, Ushijima T, Ichinose M.
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Journal Title
Gastric Cancer
Volume: 16(4)
Issue: 4
Pages: 488-497
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia.2013
Author(s)
noue I, Kato J, Yoshimura N, Maeda Y, Moribata K, Shingaki N, Deguchi H, Enomoto S, Maekita T, Ueda K, Iguchi M, Tamai H, Fujishiro M, Yamamichi N, Takeshita T, Ichinose M.
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Journal Title
Mol Clin Oncol. 2013 Jan;1(1):75-82.
Volume: 1(1)
Pages: 75-82
Related Report
Peer Reviewed
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[Journal Article] Low-dose pegylated interferon-alpha-2a monotherapy in elderly and/or cirrhotic patients infected with hepatitis C virus genotype-2 or genotype-1 low level infection.2013
Author(s)
Tamai H, Moribata K, Mori Y, Shingaki N, Deguchi H, Ueda K, Inoue I, Maekita T, Iguchi M, Kato J, Ichinose M.
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Journal Title
Hepatol Res. 2013 Jul;43(7):702-8.
Volume: 43 (7)
Issue: 7
Pages: 702-708
DOI
NAID
Related Report
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[Journal Article] A case of chronic pancreatitis in which endoscopic ultrasonography was effective in the diagnosis of a pseudoaneurysm.2012
Author(s)
Fukatsu K, Ueda K, Maeda H, Yamashita Y, Itonaga M, Mori Y, Moribata K, Shingaki N, Deguchi H, Enomoto S, Inoue I, Maekita T, Iguchi M, Tamai H, Kato J, Ichinose M.
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Journal Title
World J Gastrointest Endosc
Volume: 4
Issue: 7
Pages: 335-338
DOI
Related Report
Peer Reviewed
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