| Project/Area Number |
23592234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Arata 東邦大学, 医学部, 准教授 (60583995)
NAKAGAWA Koichi 東邦大学, 医学部, 教授 (30400823)
AOKI Yasuchika 東邦大学, 医学部, 准教授 (70584001)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | リウマチ病学 / 免疫学 / 関節リウマチ |
|---|
| Research Abstract |
To determine the percentage of IL-17-positeive cells and IL-17-expressing cell types in the rheumatoid synovium, immunohistochemical staining for IL-17 and its cell markers such as CCR6 or CD3 was performed. The ratio of IL-17-positive cells was independent of disease activity, and the percentage of IL-17+CCR6+- and IL-17+CD3+- cells was less than 10%. Then, we explored correlation between relative expression levels of TNF-alpha, IFN-gamma, and IL-17 mRNA. TNF-alpha expression levels were strongly correlated with IFN-gamma; however, no significant correlation was detected between TNF-alpha and IL-17. Correlation between IFN-gamma and IL-17 expression levels was also explored, but no significant correlation was detected.
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