| Project/Area Number |
23592246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBUYA Kazuhiro 山梨大学, 総合研究部, 助教 (30402027)
MASAMUNE Taishi 山梨大学, 総合研究部, 助教 (40324199)
IWASHITA Hironobu 山梨大学, 総合研究部, 助教 (10232670)
TERADA Yoshihide 山梨大学, 総合研究部, 助教 (80334861)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | ｾﾎﾞﾌﾙﾗﾝ / プロポフォール / エストロゲン / プロゲステロン / クラニアルウインドウ / 脳虚血・再灌流 / セボフルラン / 脳循環 / 脳血管径 / 脳虚血 |
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| Outline of Final Research Achievements |
We investigated the effects of estrogen and progesterone on cerebral pial microvessels in the nornal state and ischemia-reperfusion period under sevoflurane or propofol anesthesia.
By using bispectral index, optimal doses of sevoflurane and propofol were determined as 3.9％ and 100 mg/kg/hr, respectively.
In the normal stete, estrogen and progesterone at 10-11～10-5 mol/L did not influence cerebral pial vascular diameter under either sevoflurane or propofol anesthesia. In the ischemia-reperfusion period, estrogen and progesterone at 10-6 mol/L did not influence cerebral pial vascular diameter under either sevoflurane or propofol anesthesia.
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