Cerebral protective effects of estrogen and progesterone under sevoflurane or propofol anesthesia

• Project/Area Number: 23592246
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: University of Yamanashi
• Principal Investigator: ISHIYAMA Tadahiko 山梨大学, 総合研究部, 准教授 (90293448)
• Co-Investigator(Kenkyū-buntansha): SHIBUYA Kazuhiro 山梨大学, 総合研究部, 助教 (30402027) ; MASAMUNE Taishi 山梨大学, 総合研究部, 助教 (40324199) ; IWASHITA Hironobu 山梨大学, 総合研究部, 助教 (10232670) ; TERADA Yoshihide 山梨大学, 総合研究部, 助教 (80334861)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: ｾﾎﾞﾌﾙﾗﾝ / プロポフォール / エストロゲン / プロゲステロン / クラニアルウインドウ / 脳虚血・再灌流 / セボフルラン / 脳循環 / 脳血管径 / 脳虚血

Outline of Final Research Achievements

We investigated the effects of estrogen and progesterone on cerebral pial microvessels in the nornal state and ischemia-reperfusion period under sevoflurane or propofol anesthesia.
By using bispectral index, optimal doses of sevoflurane and propofol were determined as 3.9％ and 100 mg/kg/hr, respectively.
In the normal stete, estrogen and progesterone at 10-11～10-5 mol/L did not influence cerebral pial vascular diameter under either sevoflurane or propofol anesthesia. In the ischemia-reperfusion period, estrogen and progesterone at 10-6 mol/L did not influence cerebral pial vascular diameter under either sevoflurane or propofol anesthesia.

Research Products

• [Journal Article] The direct effects of Rho kinase-inhibitor on pial microvessels in rabbits (2015)
  • Author(s): Kotoda M, IshiyamaT, Shintani N, Matsukawa T
  • Journal Title: Ｊｏｕｒｎａｌ ｏｆ Ａｎｅｓｔｈｅｓｉａ Volume: 29 Issue: 2 Pages: 186-190
  • DOI: 10.1007/s00540-014-1903-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Effects of topical and intravenous JM-1232(-) on cerebral pial microvessels of rabbits (2015)
  • Author(s): Ikemoto K, Ishiyama T, Asano N, Shintani N, Sessler DI, Matsukawa T
  • Journal Title: ＢＭＣ Ａｎｅｓｔｈｅｓｉｏｌｏｇｙ Volume: 15 Issue: 1 Pages: 37-37
  • DOI: 10.1186/s12871-015-0016-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evaluation of optimal doses of sevoflurane and propofol in rabbits (2014)
  • Author(s): Terada Y, Ishiyama T, Asamo N, Kotoda M, Ikemoto K, Shintani N, Sessler DI, Matsukawa T
  • Journal Title: ＢＭＣ Ｒｅｓｅａｒｃｈ Ｎｏｔｅｓ Volume: 7 Pages: 820-820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The Effects of Vasopressin on Pial Microvessels During Global Brain Iscemia-Reperfusion Period in Rabbits (2013)
  • Author(s): 27. Asano N, Ishiyama T, Shintani N, Kotoda M, Mitsui K, Suzuki S, Matsukawa T
  • Organizer: ASA Annual Meeting
  • Place of Presentation: Moscone Convention Center, San Francisco, USA
• [Presentation] The effects of inhaled nitric oxide on pial microvessels in rabbits (2013)
  • Author(s): Kotoda M, Ishiyama T, Matsukawa T
  • Organizer: ASA Annual Meeting
  • Place of Presentation: Moscone Convention Center, San Francisco, USA