| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
It has been suggested as a reason for the difficulty in the lung transplantation from a brain-dead donor that brain edema and increased intracranial pressure induce neurogenic pulmonary edema (NPE) resulting in the lung function impairment. In the present study, we established an in vitro human pulmonary endothelial cell model and assessed the effect of neuropeptide Y (NPY), which was discovered as a causative agent in NPE, on cell permeability. NPY alone showed no statistically significant enhancement of cell permeability in the range from 1 x 10-11 to 1 x 10-7 M. In addition, neither hypoxic (5% O2) condition nor combination with norepinephrine caused NPY-induced cell permeability. These results suggest that the site of action of NPY is not in pulmonary endothelial cells in NPE.
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