Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor

• Project/Area Number: 23592256
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yamaguchi University
• Principal Investigator: KOBAYASHI SHIGEKI 山口大学, 医学部附属病院, 講師 (90397993)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Takeshi 山口大学, 大学院医学系研究科, 准教授 (50363122) ; YANO Masafumi 山口大学, 大学院医学系研究科, 教授 (90294628)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 悪性高熱症 / 心室頻拍症 / 心不全 / ダントロレン / リアノジン受容体 / カテコラミン誘発性心室頻拍

Research Abstract

We previously reported that dantrolene, a therapeutic agent for malignant hyperthermia (MH), prevented abnormal Ca2+ leak by correction of the defective inter-domain interaction between N-terminal and central domains in MH-type RyR. In tachycardia-induced heart failure canine model and catecholaminergic polymorphic ventricular tachycardia (CPVT)-associated RyR2R2474S /+ knock-in (KI) mice model, dantrolene binds to the specific domain in RyR2, and then corrects defective inter-domain interactions within RyR2, subsequently inhibits diastolic Ca2+ leak. In turn, dantrolene improves cardiomyocyte function in failing hearts and prevents bidirectional VT induced by injection of epinephrine or exercise in CPVT. Thus, dantrolene may have a potential to treat heart failure and lethal arrhythmia, specifically targeting RyR2.

Research Products

• [Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes (2014)
  • Author(s): Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
  • Journal Title: Biochem Biophys Res Commun Volume: (in press)
  • Peer Reviewed
• [Journal Article] A low-doseβ1 blocker effectively and safely slows heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation (2014)
  • Author(s): Kobayashi S, Murakami W, Myoren T, Tateishi H, Okuda S, Doi M, Nao T, Wada Y, Matsuzaki M. Yano M
  • Journal Title: Cardiology Volume: 127 Pages: 105-113
  • Peer Reviewed
• [Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes (2014)
  • Author(s): Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
  • Journal Title: Biochem Biophys Res Commun Volume: 448(1) Issue: 1 Pages: 1-7
  • DOI: 10.1016/j.bbrc.2014.03.152
  • Peer Reviewed / Open Access
• [Journal Article] A low-dose β 1-blocker effectively and safely slows the heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation (2014)
  • Author(s): Kobayashi S, Murakami W, Myoren T, Tateishi H, Okuda S, Doi M, Nao T, Wada Y, Matsuzaki M, Yano M
  • Journal Title: Cardiology Volume: 127(2) Issue: 2 Pages: 105-13
  • DOI: 10.1159/000355312
  • Peer Reviewed
• [Journal Article] Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy (2013)
  • Author(s): Fujita T, Fujino N, Anan R, Tei C, Kubo T, Doi Y, Kinugawa S, Tsutsui H, Kobayashi S, Yano M, Asakura M, Kitakaze M, Komuro I, Konno T, Hayash Hi, Kawashiri M, Ino H, Yamagishi M
  • Journal Title: JACC Heart Failure Volume: 6 Pages: 459-466
  • Peer Reviewed
• [Journal Article] Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy : Results From Multicenter Registration in Japan. (2013)
  • Author(s): Fujita T, Komuro I (18人中13番目）
  • Journal Title: JACC Heart Fail Volume: 6 Issue: 6 Pages: 459-466
  • DOI: 10.1016/j.jchf.2013.08.007
  • Peer Reviewed
• [Journal Article] A low-doseβblocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternansin patients with acute decompensated heart failure (2012)
  • Author(s): Kobayashi S, Susa T, Tanaka T, Murakami W, Fukuta S, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
  • Journal Title: Circ J Volume: 76 Pages: 1646-53
  • Peer Reviewed
• [Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker for predicting cardiac events and evaluating the effectiveness of carvedilol treatment in patients with chronic systolic heart failure (2012)
  • Author(s): Susa T, Kobayashi S, Tanaka T, Murakami W, Akashi S, Kunitsugu I, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
  • Journal Title: Circ J Volume: 76 Pages: 117-26
  • NAID: 10030034360
  • Peer Reviewed
• [Journal Article] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts (2012)
  • Author(s): Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
  • Journal Title: Cardiovasc Res Volume: 96 Pages: 433-43
  • Peer Reviewed
• [Journal Article] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts (2012)
  • Author(s): Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
  • Journal Title: Cardiovasc Res Volume: 96(3) Issue: 3 Pages: 433-43
  • DOI: 10.1093/cvr/cvs271
  • Peer Reviewed
• [Journal Article] Low-Dose β-Blocker in Combination With Milrinone Safely Improves Cardiac Function and Eliminates Pulsus Alternans in Patients With Acute Decompensated Heart Failure (2012)
  • Author(s): Shigeki Kobayashi et al
  • Journal Title: Circulation Journal Volume: 76 Issue: 7 Pages: 1646-1653
  • DOI: 10.1253/circj.CJ-12-0033
  • NAID: 10030503344
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Urinary 8-Hydroxy-2'-Deoxyguanosine as a Novel Biomarker for Predicting Cardiac Events and Evaluating the Effectiveness of Carvedilol Treatment in Patients With Chronic Systolic Heart Failure (2012)
  • Author(s): Susa T, et al
  • Journal Title: Circulation Journal Volume: 76 Issue: 1 Pages: 117-126
  • DOI: 10.1253/circj.CJ-11-0537
  • NAID: 10030034360
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia (2011)
  • Author(s): Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
  • Journal Title: Circulation Volume: 124 Pages: 682-94
  • Peer Reviewed
• [Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure (2011)
  • Author(s): Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M
  • Journal Title: Eur J Heart Fail Volume: 13 Pages: 29-36
  • Peer Reviewed
• [Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca^<2+> release leading to catecholaminergic polymorphic ventricular tachycardia (2011)
  • Author(s): Takeshi Suetomi
  • Journal Title: Circulation Volume: 124 Issue: 6 Pages: 682-694
  • DOI: 10.1161/circulationaha.111.023259
  • Peer Reviewed
• [Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure (2011)
  • Author(s): Shigeki Kobayashi
  • Journal Title: European Journal of Heart Faililure Volume: 13 Issue: 1 Pages: 29-36
  • DOI: 10.1093/eurjhf/hfq178
  • Peer Reviewed
• [Presentation] Relationship between Cardiac 18F-FDG-PET/CT Imaging and Urinary 8-hydroxy-2'-deoxyguanosine as a Biomarker of Oxidative Stress in Patients with Cardiac Sarcoidosis (2014)
  • Author(s): Shigeki Kobayashi, Wakako Murakami, Takeki Myoren, Masakazu Fukuda, Kosuke Uchida, Makoto Ono, Hiroki Tateishi, Tetsuro Oda, Ryosuke Kametani, Tomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Masafumi Yano
  • Organizer: 第７8回日本循環器学会学術集会
  • Place of Presentation: 東京、国際フォーラム
• [Presentation] A Novel Selective EP4 Receptor Agonist Improves Cardiomyocyte Function by Inhibiting Ca2+ Leak through the Ryanodine Receptor in Failing Cardiomyocytes (2014)
  • Author(s): Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
  • Organizer: 第７8回日本循環器学会学術集会
  • Place of Presentation: 東京、国際フォーラム
• [Presentation] Mapping the Binding Site of RyR2 “Unzipping” Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes (2014)
  • Author(s): Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • Organizer: 第７8回日本循環器学会学術集会
  • Place of Presentation: 東京、国際フォーラム
• [Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation (2014)
  • Author(s): Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
  • Organizer: 第７8回日本循環器学会学術集会
  • Place of Presentation: 東京、国際フォーラム
• [Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding (2014)
  • Author(s): Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • Organizer: 第７8回日本循環器学会学術集会
  • Place of Presentation: 東京、国際フォーラム
• [Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure (2014)
  • Author(s): Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • Organizer: 第７8回日本循環器学会学術集会
  • Place of Presentation: 東京、国際フォーラム
• [Presentation] Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy (2014)
  • Author(s): Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
  • Organizer: 第７8回日本循環器学会学術集会
  • Place of Presentation: 東京、国際フォーラム
• [Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca^<2+> Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes (2013)
  • Author(s): Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
  • Organizer: 86th Scientific Session of American Heart Association
  • Place of Presentation: Dallas, (U.S.A)
• [Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy (2013)
  • Author(s): Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
  • Organizer: 86th Scientific Session of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes (2013)
  • Author(s): Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
  • Organizer: 86th Scientific Session of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation (2013)
  • Author(s): Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
  • Organizer: 86th Scientific Session of American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Dantrolene inhibits aberrant Ca2+ release by stabilizing inter-domain interactions within the ryanodine receptor in cardiac troponin T-related familial hypertrophic cardiomyopathy (2013)
  • Author(s): Shinichi Okuda, Masakazu Fukuda, Akihiro Hino, Takayoshi Katoh, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki, Masafumi Yano
  • Organizer: European Society of Cardiololgy Congress 2013
  • Place of Presentation: Amsterdam, Nederland
• [Presentation] Elevated Myocardial Oxidative Stress Induced by Catecholamines Related to Transient Left Ventricular Cysfunction in Patients With Takotsubo Cardiomyopathy (2012)
  • Author(s): Wakako Murakami, Shigeki Kobayashi, Tadamitsu Nakashima, Hiroki Tateishi, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
  • Organizer: 85th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles, (U.S.A) (Oral)
• [Presentation] Urinary 8-hydroxy-2'-deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosis (2012)
  • Author(s): Shigeki Kobayashi, Wakako Murakami, Seiko Fukuta, Masakazu Fukuda, Shinichi Okuda, Tomoko Nao, Masahiro Doi, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • Organizer: 85th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles, (U.S.A) (Oral)
• [Presentation] Fixing Ca^<2+> Leakage From Cardiac Ryanodine Receptor by Low-dose ofβBlocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure (2012)
  • Author(s): Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
  • Organizer: 5th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles, (U.S.A) (Oral)
• [Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Marker of Left Ventricular Remodelling in Patients With Dilated Cardiomyopathy (2012)
  • Author(s): Wakako Murakami, Shigeki Kobayashi, Takamasa Oda, Hiroki Tateishi, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
  • Organizer: 85th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles, (U.S.A) (Poster)
• [Presentation] Urinary 8-hydroxy-2'-deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosis (2012)
  • Author(s): Shigeki Kobayashi, Wakako Murakami, Seiko Fukuta, Masakazu Fukuda, Shinichi Okuda, Tomoko Nao, Masahiro Doi, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • Organizer: 85th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles (USA)
• [Presentation] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose of β Blocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure (2012)
  • Author(s): Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
  • Organizer: 85th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles (USA)
• [Presentation] Elevated Myocardial Oxidative Stress Induced by Catecholamines Related to Transient Left Ventricular Cysfunction in Patients With Takotsubo Cardiomyopathy (2012)
  • Author(s): Murakami W, Kobayashi S, Nakashima T,Tateishi H, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T,Yano M, Matsuzaki M
  • Organizer: 85th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles (USA)
• [Presentation] Enhanced Binding of Calmodulin to RyR2 Inhibits Aberrant Ca2+ Release and Arrhythmogenesis in CPVT-Associated Mutation (2012)
  • Author(s): Fukuda M, Yamamoto T, Kato T, Hino A, Suetomi T, Tateishi H, Doi M, Okuda S, Kobayashi S, Matsuzaki M, Yano M
  • Organizer: 85th Scientific Session of American Heart Association
  • Place of Presentation: Los Angeles(USA)
• [Presentation] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia (2011)
  • Author(s): Shigeki Kobayashi, Masafumi Yano,Takeshi Yamamoto, Masunori Matsuzaki
  • Organizer: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: The National Center of Science Building(Tokyo) (Symposium)
• [Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis : Insight From Immunohistochemical Technique and ^<18>F-FDG PET/CT (2011)
  • Author(s): Seiko Fukuta, Shigeki Kobayashi, Takeo Tanaka, Takehisa Susa, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Shuji Kawamura,Masafumi Yano, Masunori Matsuzaki
  • Organizer: 84rd Scientific Session of American Heart Association
  • Place of Presentation: Orlando (U.S.A) (Poster) (Circulation.2011 ;124:A10269)
• [Presentation] Low-dose ofβblocker in combination with milrinone improve cardiac function in patients with acute decompensated heart failure (2011)
  • Author(s): Shigeki Kobayashi, Takehisa Susa,Tanaka Takeo, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Tomoko Nao, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • Organizer: European Society of Cardiololgy Congress 2011
  • Place of Presentation: Paris(France)(Eur Heart J32[Suppl 1] :785)
• [Presentation] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia (2011)
  • Author(s): Shigeki Kobayashi, Masafumi Yano, Takeshi Yamamoto, Masunori Matsuzaki
  • Organizer: The 28th Annual Meeting of the International Society for Heart Research Japanese Section(招待講演)
  • Place of Presentation: The National Center of Science Building, Tokyo
• [Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis: Insight From Immunohistochemical Technique and 18F-FDG PET/CT (2011)
  • Author(s): Fukuta S, Kobayashi S, Tanaka T, Susa T, Murakami W, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Ueyama T, Okamura T, Kawamura S, Yano M, Matsuzaki M
  • Organizer: 84rd Scientific Session of American Heart Association
  • Place of Presentation: Orland, FL, USA
• [Presentation] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) (2011)
  • Author(s): Takeshi Suetomi; Masafumi Yano; Takayoshi Kato; Masakazu Fukuda; Akihiro Hino; Masahiro Doi; Shinichi Okuda; Shigeki Kobayashi; Yasuhiro Ikeda; Takeshi Yamamoto; Masunori Matsuzaki
  • Organizer: 84rd Scientific Session of American Heart Association
  • Place of Presentation: Orland, FL, USA
• [Presentation] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation (2011)
  • Author(s): Masakazu Fukuda, Masafumi Yano, Takayoshi Kato, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
  • Organizer: 84rd Scientific Session of American Heart Association
  • Place of Presentation: Orland, FL, USA
• [Presentation] Low-dose of β blocker in combination with milrinone improve cardiac function in patients with acute decompensated heart failure (2011)
  • Author(s): Shigeki Kobayashi, Takehisa Susa,Tanaka Takeo, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Tomoko Nao, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
  • Organizer: European Society of Cardiololgy Congress 2011
  • Place of Presentation: Paris, France
• [Book] β遮断薬を使いこなす -生命予後の改善を目指して- (2013)
  • Author(s): 小林 茂樹、矢野雅文
  • Total Pages: 107
  • Publisher: 月刊循環器
• [Book] β遮断薬を臨床で活かす。 (2013)
  • Author(s): 小林 茂樹、矢野雅文
  • Total Pages: 172
  • Publisher: 南江堂
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~ninai/result/paper_eng.html
• [Remarks] 山口大学大学院医学系研究科 器官病態内科学 ホームページ
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~ninai/medi/stuff.html