Neuroprotective effect of fructose water-soluble alpha-lipoic acid: a 31P-NMR study
| Project/Area Number |
23592259
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOKUMARU Osamu 大分大学, 医学部, 准教授 (40360151)
YOKOI Isao 大分大学, 医学部, 教授 (80150366)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | αリポ酸 / 脳保護 / フリーラジカル / 虚血再灌流負荷 / 核磁気共鳴法 / 電子スピン共鳴法 / ラジカルスカベンジャー / 高エネルギーリン酸 / 脳保護作用 / 高エネルギー燐酸 / スピントラップ / 脳虚血 / クレアチンリン酸 / ATP / 病態生理学 |
|---|
| Research Abstract |
Despite its strong antioxidative and anti-inflammatory activity, application of alpha-lipoic acid has been limited due to its water-insolubility. The neuroprotective effect of a newly-developed water-soluble derivative of alpha-lipoic acid was studied using 31P-nuclear magnetic resonance spectroscopy. The recovery of high-energy phosphates, ATP and phosphocreatine (energetic buffer of ATP in living cells), was significantly higher when brain slices were superfused with water-soluble alpha-lipoic acid. The electron spin resonance spectroscopy indicated a wide range of free radical scavenging activity of the water-soluble alpha-lipoic acid.
|
Report
(4 results)
Research Products
(36 results)
