Effects of Vitamin E Derevative , ETS-GS for the treatment of acute hepatitis

• Project/Area Number: 23592260
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Oita University
• Principal Investigator: SHINGU Chihiro 大分大学, 医学部, 准教授 (30295191)
• Co-Investigator(Kenkyū-buntansha): 野口 隆之 大分大学, 医学部, 教授 (90156183)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 急性肝障害 / 酸化ストレス / ビタミンE / タウリン / グルタチオン / 新規ビタミンE誘導体 / 臓器障害 / 肝機能異常 / 新規治療薬開発 / 治療薬開発 / 細胞内リン酸化 / 新規誘導体

Research Abstract

We evaluated effects of ETS-GS , a new vitamin E derivative ,in rat model of acute hepatitis due to acetaminophen-administration. We compared at histological and biological change ,that ETS-GS attenuates acetaminophen-induced liver injury ,and the result suggested potential therapeutic ability of ETS-GS.