| Project/Area Number |
23592266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Ryuta 東京医科大学, 医学部, 助教 (20459572)
KANEKO Kohki 東京医科大学, 医学部, 助教 (40617536)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBASAKI Futoshi (財)東京都医学研究機構, 東京都臨床医 学総合研究所, 副参事研究員 (90300954)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 敗血症性脳症状 / ミトコンドリア / Ca2+ / ＣＲＣ / RCR / swelling / ミトコンドリア呼吸能(ＲＣＲ) / SAEモデル / state3 / state4 / 国際研究者交流 スエーデン / 敗血症 / マウス / ラット / ミトコンドリア機能不全 / 敗血症性脳症 |
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| Research Abstract |
To investigate the mechanisms of septic Encephalopathy(SE), we focused on the mitochon drial dysfunction. Firts year, The swelling assay suggested that brain has showed significant swelling due to Ca2 + loading comapred to control(control vs 1,6,12,24h, p<0.05). Seccond year, Calcium Retention Capacity. Sepsis significantly inhibited the CRC according to the recovery time(control vs 1,6,12,24h, p<0.05). Last year, we have investigated the mitochondrial respiratory control ratio(RCR) due to Klark elctrode assay. RCR was strongly reduced according to the recovery time. Especially, 12 and 24h after recovery, CLP group showed significant reduction of RCR compare to control(P<0.05).
Septic encephalopathy showed the inhibition of mitochondrial function.
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