Effects of inhalation and intravenous anesthetic drugs for Ca2+ uptake capacity and respiratory function in mitochondria of the platelets.

Research Project

Project/Area Number	23592267
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Tokyo Medical University
Principal Investigator	NOGUCHI MASASHI 東京医科大学, 医学部, 講師 (70343522)
Co-Investigator(Kenkyū-buntansha)	IWASE Naoto 長崎大学, 大学院医歯(薬)学総合研究科, 教授 (40408141) ANDO Chihiro 東京医科大学, 医学部, 助教 (50420980) TOMINO Mikiko 東京医科大学, 医学部, 助教 (30459523)
Co-Investigator(Renkei-kenkyūsha)	UCHINO Hiroyuki 東京医科大学, 医学部, 主任教授 (60266476)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	ミトコンドリア / 麻酔薬 / 国際研究者交流 / スウェーデン
Research Abstract	In freshly isolated and permeabilized human platelets the commonly used anesthetic agents sevoflurane and propofol stimulate certain aspects of mitochondrial res- piratory capacity at clinically relevant concentrations. At higher concentrations, these agents displayed a dose- dependent inhibition of complex I and II-supported res- piration. The increased respiratory capacity induced by sevoflurane and propofol might be beneficial and the inhibition of respiration could be relevant to situa- tions of prolonged or excessive exposure, especially in situations of tissue accumulation of these anesthetic agents.