| Project/Area Number |
23592267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWASE Naoto 長崎大学, 大学院医歯(薬)学総合研究 科, 教授 (40408141)
ANDO Chihiro 東京医科大学, 医学部, 助教 (50420980)
TOMINO Mikiko 東京医科大学, 医学部, 助教 (30459523)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHINO Hiroyuki 東京医科大学, 医学部, 主任教授 (60266476)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ミトコンドリア / 麻酔薬 / 国際研究者交流 / スウェーデン |
|---|
| Research Abstract |
In freshly isolated and permeabilized human platelets the commonly used anesthetic agents sevoflurane and propofol stimulate certain aspects of mitochondrial res- piratory capacity at clinically relevant concentrations. At higher concentrations, these agents displayed a dose- dependent inhibition of complex I and II-supported res- piration. The increased respiratory capacity induced by sevoflurane and propofol might be beneficial and the inhibition of respiration could be relevant to situa- tions of prolonged or excessive exposure, especially in situations of tissue accumulation of these anesthetic agents.
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