Project/Area Number |
23592268
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Kanazawa Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SHIBAMOTO Toshishige 金沢医科大学, 医学部, 教授 (90178921)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 肝虚血再灌流障害 / 脂肪肝 / 肥満 / 運動 / 摘出灌流肝 / 肝組織血流量 |
Research Abstract |
Steatotic livers are known to be vulnerable to ischemia-reperfusion (I/R) injury during hepatic surgery and liver transplantation. Exercise training is recommended to prevent obesity-associated disorders. However, it remains unknown whether exercise training attenuates I/R injury of steatotic liver. We determined, using the hyperphagic, Otsuka Long-Evans Tokushima Fatty (OLETF) rat and the control Long-Evans Tokushima Otsuka (LETO) rat, effects of exercise training on I/R injury under both anesthesia and isolated liver perfusion. Running training was given on a motorized treadmill for four weeks from 19-th week. In both preparations of isolated perfused livers and anesthetized rats, I/R-induced liver injury was greater in the OLETF rats than that of LETO rats. Exercise training prevented the development of steatotic livers and attenuated the I/R injury, as observed in non-exercise OLETF rats. In conclusion, exercise training attenuates I/R injury of steatotic livers from OLETF rats.
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