The aggressive treatment strategy for septic adrenal insufficiency

• Project/Area Number: 23592271
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Tohoku University
• Principal Investigator: EJIMA YUTAKA 東北大学, 大学病院, 准教授 (90301051)
• Co-Investigator(Kenkyū-buntansha): MATSUBARA Mitsunobu 東北大学, 大学院医学系研究科, 准教授 (30282073) ; TOYAMA Hiroaki 東北大学, 大学病院, 講師 (00375007) ; ENDO Yasuhiro 東北大学, 大学病院, 助教 (40375051)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 敗血症 / アルドステロン / 副腎不全

Research Abstract

Steroid is divided into two kinds of glucocorticoid and mineral corticoid. The representation of mineral corticoid is aldosterone. Most of medical scientists consider aldosterone as a cause of inflammation and useless. But blood aldosterone level shows low in some sever septic patient, and low aldosterone concentration in itself cause one of inflammation pathogenesis possibly. We studied steroid supplement treatment for sever septic adreanal insufficiency rat. The supplement method is only dexamethasone or only aldosterone or both. Adrenalectomized sepsis rat supplemented with only dexamethasone or aldosterone could not survive. We thought that the existence of both corticoids has specific effective effect on adrenalectomized sepsis rat living.