Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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Research Abstract |
This study was conducted to evaluate the effect of preoperative 2 hrs restraint stress on microglial activation, an expression of interleukin-1beta in hippocampus and spatial working memory after surgery in adult and aged rats. Spatial working memory was affected after surgery in a 6-8 months adult rat undergoing preoperative 2 hrs restraint stress. In a 18-20 months aged rat, surgery itself induced postoperative impairment of spatial working memory. However, the impairment continued even on the 14 postoperative days in an aged rat undergoing preoperative 2 hrs restraint stress. Those were associated with microglial activation and an increased expression of interleukin-1beta on neuron in hippocampus.
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