| Project/Area Number |
23592275
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Gunma University |
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Principal Investigator |
ASO CHIZU 群馬大学, 医学(系)研究科(研究院), 助教 (40436308)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
OHSHIMA Noriyasu 群馬大学, 大学院医学系研究科, 助教 (30360514)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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|---|
| Keywords | カンナビノイド / 神経発達 |
|---|
| Research Abstract |
It is known that 2-arachidonoilglycerol(2-AG) affects a sedative and an analgesic action, and neuronal development through a cannabinoid(CB) 1 receptor in the nervous system. From the rat brain, partial purification of the fraction with 2-AG production activity was carried out, and it is analyzed by mass spectrometer after trypsin digestion, and identified single protein. The protein distributed ubiquitously in the rat brain, with higher levels of expression in the hippocampus, midbrain, and medulla. Moreover, the influence of 2-AG on the peripheral nerve was considered using the spine dorsal root ganglion separated from the chicken egg on the viviparous 7th dat. When 2-AG was added to the culture solution, nerve growth cone collapse and nerve extension reduction was observed. This phenomenon rivaled by the antagonist of the CB receptor
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