| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Research Abstract |
In clinically, very low dose ketamine intravenous infusion reduced the pain dramatically some of the neuropathic pain cases. We investigated the effects of NMDA receptor antagonist, ketamine, on noxious synaptic transmission in the substantia gelatinosa (SG) with the whole cell patch-clamp technique. In the neuropathic pain model rat spinal cord, percentage of neurons with polysynaptic A-delta fiber EPSCs increased to over 90 % of the sampled population.
Moreover, this polysynaptic EPSC was inhibited by ketamine. A similar result was provided in the in-vivo patch clamp recordings. Therefore, it was revealed that the NMDA receptor strongly participated in alternation of synaptic response on the neuropathic pain model rat spinal cord.
|
