Insulin preconditioning elevates p-Akt and cardiac contractility after reperfusion in the isolated ischemic rat heart
| Project/Area Number |
23592280
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
SATO Hiroaki 山梨大学, 医学部附属病院, 助教 (20402026)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGUCHI Takeshi 山梨大学, 医学工学総合研究部, 准教授 (60201399)
MATSUKAWA Takashi 山梨大学, 医学工学総合研究部, 教授 (80209519)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | インスリン / 虚血再灌流障害 / 心筋保護 / Insulin / preconditioning effect / rat heart / ischemia |
|---|
| Research Abstract |
The optimal timing of insulin institution related to cardiac ischemia was unclear.We tested the hypothesis that insulin administered prior to ischemia provides better cardioprotection than insulin administration after ischemia.
Hearts isolated from male rats were prepared using Langendorff method and divided into three groups.
In this study, we concluded insulin administration prior to ischemia provides better cardioprotection than insulin administration only at reperfusion in the isolated ischemic rat heart.
|
Report
(4 results)
Research Products
(9 results)
