| Project/Area Number |
23592283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Mie University |
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Principal Investigator |
ZHANG Erquan 三重大学, 医学(系)研究科(研究院), 助教 (30456727)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Kazuo 三重大学, 大学院医学系研究科, 教授 (20181828)
MARUYAMA Junko 鈴鹿医療科学大学, 医用工学部, 教授 (50263017)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 人工呼吸器誘発肺傷害 / 硫化水素 / VILI / H2S / 国際情報交流 |
|---|
| Research Abstract |
Ventilator induced lung injury (VILI) was caused by mechanical ventilation with high tidal volume. In this study, the mechanical ventilation conditions that caused VILI was demonstrated in rats. Inhibitory effect of VILI was investigated by administration of NaHS. The lung water content and protein permeability (Evans Blue) were increased in mechanical ventilation by high tidal volume (35ml/kg) compared with low tidal volume (6ml/kg). In both one time and two time administration of NaHS, the lung water content, Evans Blue and arterial oxygen pressure (PaO2) had no change in mechanical ventilation by high tidal volume. The mechanical ventilation with high tidal volume increased IL-6, IL-1, and MCP-1 mRNA expression, which had trend to decrease by administration of NaHS.
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