| Project/Area Number |
23592289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | セロトニン / 片頭痛 / 脊髄 / 動物行動学実験 / トリプタン / マウス / 疼痛行動 / ５HT / 社交性試験 / 情動 / ５ＨＴ / 癌性疼痛 / スマトリプタン / モルヒネ / 脊髄鎮痛 / 疼痛関連行動 / 自発痛 / ５HT1 / 侵害受容 / 炎症性疼痛 |
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| Outline of Final Research Achievements |
Sumatriptan is widely used for the treatment of migraine . This drug targets the serotonin receptor subtypes 1B, 1D, and 1F. Although clinical use of sumatriptan is only for headache, we have previously shown that intrathecal sumatriptan has antinociceptive activity in mouse behavioral models of non-migrainous, somatic and visceral inflammatory pain.Purpose of experiments were to investigate the detail mechanism of serotonin receptor subtypes. Pharmacological experiments with agonist and antagonnist of each receptor were performed with formalin tests in mice.The anti-hyperalgesic property of intrathecal sumatriptan in the formalin test is not mediated by a single receptor subtype but by the combined action of the serotonin receptor subtypes1B and 1D. In further experiments, we found that sumatritan exerts its antinociceptive effect on the site of post synapse in spinal cord and sumatriptan does not have anti-hiperalgesic effect in cancer pain model.
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