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Development of New Algorism for Hemodynamic Management

Research Project

Project/Area Number 23592294
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKochi University

Principal Investigator

YAMASHITA KOICHI  高知大学, 教育研究部医療学系, 准教授 (80335950)

Co-Investigator(Kenkyū-buntansha) ABE Hidehiro  高知大学, 教育研究部医療学系, 助教 (20335920)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords脈波伝搬時間 / 呼吸性変動 / 心拍出量 / PEEP / 輸液応答性 / 循環管理アルゴリズム / 脈波伝播時間 / 循環管理 / アルゴリズム
Research Abstract

Application of positive end-expiratory pressure (PEEP) was known to lead a decreasing in cardiac output (CO). For predicting CO changes, respiratory variation in hemodynamic parameter has known to useful parameter. Pulse wave transit time (PWTT), measured as the interval from the ECG R wave to the pulse plethysmograph upstroke, is recently introduced to non-invasively assess cardiovascular response including CO. We hypothesized that PWTT variation (PWTTV) might be a useful parameter to predict CO change. The present study, therefore, examined the ability of PWTTV for estimated CO change. Adult pigs weighting 40kg were anesthetized and tracheostomy was undertaken. Mechanical ventilation was started with 12ml/kg in tidal volume. CO was measured by thermodilution method. PEEP was changed from 0 to 15 cmH2O step by step by 5 cmH2O interval and calculated PWTTV. From this study, we concluded that PWTTV might be a useful parameter to estimate >15% changes in CO induced by PEEP.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (19 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Oral carbohydrate loading with 18% carbohydrate beverage alleviates insulin resistance2013

    • Author(s)
      Tamura T, Yatabe T, Kitagawa H, Yamashita K, Hanazaki K, Yokoyama M
    • Journal Title

      Asia Pac J Clin Nutr

      Volume: 22 Pages: 48-53

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a novel artificial pancreas : closed loop glycemic control system with continuousblood glucose monitoring2013

    • Author(s)
      Tsukamoto Y, Kinoshita Y, Kitagawa H, Munekage M, Munekage E, Takezaki Y, Yatabe T, Yamashita K, Yamazaki R, Okabayashi T, Tarumi M, Kobayashi M, Mishina S, Hanazaki K
    • Journal Title

      Artif Organs

      Volume: 37 Pages: 67-73

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 重症僧帽弁閉鎖不全症を合併した副腎褐色細胞腫摘出術の麻酔経験2013

    • Author(s)
      田村貴彦,矢田部智昭,山下幸一,横山正尚
    • Journal Title

      日臨麻会誌

      Volume: 33 Pages: 815-9

    • NAID

      10031196408

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of perioperative outcome for esophagectomy by thoracoscopy in the prone position with that for thoracotomy in the lateral decubitus position2012

    • Author(s)
      Yatabe T, Kitagawa H, Yamashita K, Hanazaki K, Yokoyama M
    • Journal Title

      Surg Today

      Volume: 13(Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of administration of 1% glucose solution on neonatal blood glucose concentration in cesarean section2012

    • Author(s)
      Yatabe T, Tateiwa H, Ikenoue N, Kitamura S, Yamashita K, Yokoyama M
    • Journal Title

      J Anesth

      Volume: 7(Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The evaluation of the ability of closed loop glycemic control device to maintain the blood glucose concentration in ICU patients2011

    • Author(s)
      T Yatabe, R Yamazaki, H Kitagawa, T Okabayashi, K Yamashita, K Hanazaki, M Yokoyama
    • Journal Title

      Crit Care Med

      Volume: 39 Pages: 8-575

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative carbohydrate-rich beverage reduces hypothermia during general anesthesia in rats2011

    • Author(s)
      T Yatabe, T Kawano, K Yamashita, M Yokoyama
    • Journal Title

      J Anesth

      Volume: 25 Pages: 62-558

    • NAID

      10029601216

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous monitoring of glucose levels in the hepatic vein and systemic circulation during the Pringlemaneuver in beagles2011

    • Author(s)
      Yatabe T, Kitagawa H, Kawano T, Munekage M, Okabayashi T, Yamashita K, Hanazaki K, Yokoyama M
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 7-232

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative oralrehydration therapy with 2.5% carbohydrate beverage alleviates insulin action in volunteers

    • Author(s)
      T Yatabe, T Tamura, H Kitagawa, T Namikawa, K Yamashita, K Hanazaki, M Yokoyama
    • Journal Title

      J Artif Organs

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 脈波伝搬時間の呼吸性変動と心拍出量変化の関係2013

    • Author(s)
      山本賢太郎,山下幸一,田村貴彦,矢田部智昭,横山正尚
    • Organizer
      日本麻酔科学会中国・四国支部第50回学術集会
    • Place of Presentation
      高松,サンポートホール高松
    • Year and Date
      2013-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 心音を用いた非侵襲的心収縮力モニタリングの検討2013

    • Author(s)
      山下幸一,田村貴彦,阿部秀宏,矢田部智昭,岡崎想,濱口真有子,山本賢太郎,横山正尚
    • Organizer
      日本臨床麻酔学会第33回大会
    • Place of Presentation
      金沢石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] Can PWTT detect a decrease of cardia c output induced by mechanical ventilat2013

    • Author(s)
      K. Yamashita, T. Kawano, T. Yatabe, H. Abe, M. Yokoyama
    • Organizer
      ionIARS 2013 Annual Metting
    • Place of Presentation
      San Diego, CA.USA, Sheraton Hotel & Marina
    • Related Report
      2013 Final Research Report
  • [Presentation] 脈波伝搬時間の呼吸性変動はPEEPによる心拍出量変化を予測できるか?-豚を用いた実験的検討-2013

    • Author(s)
      山下幸一,立岩浩規,田村貴彦,矢田部智昭,阿部秀宏,山崎史幹,河野崇,横山正尚
    • Organizer
      第40回日本集中治療医学会学術集会
    • Place of Presentation
      松本,長野県松本文化会館,松本市総合体育館,まつもと市民芸術館,松本市浅間温泉文化センター
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 心音を用いた非侵襲的心収縮力モニタリングの検討2013

    • Author(s)
      山下幸一,田村貴彦,阿部秀宏,矢田部智昭,岡崎想,濱口真有子,山本賢太郎,横山正尚
    • Organizer
      日本臨床麻酔学会第33回大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] Can PWTT detect a decrease of cardiac output induced by mechanical ventilation2013

    • Author(s)
      K. Yamashita, T. Kawano, T. Yatabe, H. Abe, M. Yokoyama
    • Organizer
      ARS 2013 Annual Metting
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] CAN PWTTV DETECT A CECREASING OF CARDIAC OUTPUT INDUCED BY MECHANICAL VENTILATION?2013

    • Author(s)
      Koichi Yamashita
    • Organizer
      International Anesthesia Research Society 2013 Annual Meeting
    • Place of Presentation
      Sheraton Hotel & Marina, San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 脈波伝搬時間の呼吸性変動の輸液応答性に関する実験的検討2012

    • Author(s)
      山下幸一,山本賢太郎,阿部秀宏,井本明伸,矢田部智昭,横山正尚
    • Organizer
      日本麻酔科学会中国・四国支部第49回学術集会
    • Place of Presentation
      高知,高知市文化プラザかるぽーと
    • Year and Date
      2012-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 脈波伝搬時間の呼吸性変動は脈圧変動よりも正確に輸液応答性を予測できるか?2012

    • Author(s)
      山下幸一,立岩浩規,田村貴彦,矢田部智昭,山崎史幹,河野崇,横山正尚
    • Organizer
      第17回日本心臓血管麻酔学会学術大会
    • Place of Presentation
      仙台,仙台国際センター
    • Related Report
      2013 Final Research Report
  • [Presentation] Oral carbohydrate loading with 18% car bohydrate beverage alleviates insulin r esistance2012

    • Author(s)
      T.Tamura, T.Yatabe, K.Yamashita, M.Yo koyama
    • Organizer
      ESPEN2012
    • Place of Presentation
      Barcel ona,Spain, International Convention Cen tre of Barcelona
    • Related Report
      2013 Final Research Report
  • [Presentation] Pulse transit time can predict the he modynamic effects of positive pressure ventilation2012

    • Author(s)
      K. Yamashita, T. Kawano, T. Yatabe, H. Abe, M. Yokoyama
    • Organizer
      IARS 2012 Annual Meeting
    • Place of Presentation
      Boston, MA,USA, Marriot t Copley Plaza
    • Related Report
      2013 Final Research Report
  • [Presentation] Continuous blood glucose monitoring re vealed that blood glucose levels change markedly in a short time during surger y for pheochromocytoma2012

    • Author(s)
      T Tamura, T Yatabe, H Tateiwa, T Kawa no, K Yamashita, M Yokoyama
    • Organizer
      15th World Cong ress of Anaesthesiologists
    • Place of Presentation
      Buenos Aires,Argentina, The Rural Exhi bition
    • Related Report
      2013 Final Research Report
  • [Presentation] Can pulse transit time variation estimate the hemodynamic effects of positive pressure ventilation -a comparison with stroke volume variation and pulse pressure variation-2012

    • Author(s)
      Koichi Yamashita
    • Organizer
      International Anesthesia Research Society 2012 Annual Meeting
    • Place of Presentation
      Marriott Copley Place, Boston, Massachusetts, Boston, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Can pulse wave transit time variation predict a fluid responsiveness more precisely compared with pulse pressure variation?2012

    • Author(s)
      Koichi Yamashita
    • Organizer
      Europian Society of Intensive Care Medicine 2012 Annual Meetig
    • Place of Presentation
      Centro de Congressos de Lisboa (CCL), Lisbon, Portgeal
    • Related Report
      2012 Research-status Report
  • [Presentation] 脈波伝搬時間の呼吸性変動は陽圧人工呼吸による心拍出量変化を予測できる2012

    • Author(s)
      山下幸一
    • Organizer
      第39回日本集中治療医学会総会
    • Place of Presentation
      幕張メッセ、幕張
    • Related Report
      2012 Research-status Report
  • [Presentation] 脈波伝搬時間の呼吸性変動はPEEP負荷による心拍出量変化を予測できるか?2012

    • Author(s)
      山下幸一
    • Organizer
      日本麻酔科学会第59回学術総会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場、神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 脈波伝搬時間の呼吸性変動は脈圧変動よりも正確に輸液応答性を予測できるか?2012

    • Author(s)
      山下幸一
    • Organizer
      日本心臓血管麻酔学会第17回学術総会
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2012 Research-status Report
  • [Presentation] 脈波伝搬時間の呼吸性変動と心拍出量変化の関係

    • Author(s)
      山本賢太郎、山下幸一、田村貴彦、矢田部智昭、阿部秀宏、河野崇、横山正尚
    • Organizer
      日本麻酔科学会第50回中国四国支部会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脈波伝搬時間の呼吸性変動の輸液応答性に関する実験的検討

    • Author(s)
      山下幸一
    • Organizer
      本麻酔科学会中国・四国支部 第49回学術総会
    • Place of Presentation
      高知市文化プラザかるぽーと、高知
    • Related Report
      2012 Research-status Report
  • [Book] 横山正尚麻酔科医のための循環管理の実際(横山正尚専門編集)5-4循環管理の新たな指標と可能性2013

    • Author(s)
      山下幸一
    • Publisher
      中山書店,東京
    • Related Report
      2013 Final Research Report
  • [Book] 重症僧帽弁閉鎖不全症を合併した副腎褐色細胞腫摘出術の麻酔経験2013

    • Author(s)
      田村貴彦,矢田部智昭,山下幸一,横山正尚
    • Publisher
      日臨麻会誌
    • Related Report
      2013 Final Research Report
  • [Book] 麻酔科医のための循環管理の実際(横山正尚 専門編集)2013

    • Author(s)
      山下幸一,横山正尚
    • Total Pages
      500
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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