Effects of volatile anesthetics on ischemia-reperfusion injury in Non-alcoholic steatohepatitis rats: interaction with anti-diabetic drugs

• Project/Area Number: 23592297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: CHO Sungsam 長崎大学, 大学病院, 講師 (90325655)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 非アルコール性脂肪肝炎 / 虚血再灌流傷害 / 肝臓 / 揮発性麻酔薬 / チアゾリン薬 / インクレチン

Research Abstract

Volatile anesthetic sevoflurane, thiazolidinedione pioglitazone, and glucagon-like peptide 1 liraglutide administered before ischemia would prevent ischemia-reperfusion-induced liver damage, apoptosis, or survival rate. Non-alcoholic steatohepatitis (NASH) rats resulted in more ischemia-reperfusion-induced liver damage and decreased a survival rate as compared with normal rats. And the protective effects of sevoflurane, pioglitazone, and liraglutide have been inhibited in NASH rats. The combination sevoflurane and pioglitazone administered before ischemia would prevent ischemia-reperfusion-induced liver damage, apoptosis, or survival rate in NASH rats. This combination has better protection than sevoflurane, pioglitazone, and liraglutide alone in NASH rats.

Research Products

• [Journal Article] Milrinone-induced postconditioning reduces hepatic ischemia-reperfusion injury in rats: the roles of phosphatidylinositol 3-kinase and nitric oxide. (2013)
  • Author(s): Toyoda T, Tosaka S, Tosaka R, Maekawa T, Cho S, Eguchi S, Nakashima M, Sumikawa K
  • Journal Title: Journal of Surgical Research Volume: 186(1) Issue: 1 Pages: 446-451
  • DOI: 10.1016/j.jss.2013.09.007
  • NAID: 120006986798
  • Peer Reviewed
• [Journal Article] Olprinone, a phosphodiesterase type III inhibitor, has pharmacological postconditioning properties against renal and heart ischemia-reperfusion injury (2013)
  • Author(s): 鶴長容子、戸坂真也、戸坂玲子、三好宏、前川拓治、趙成三、澄川耕二
  • Journal Title: Anesth Resus Volume: 49 Pages: 75-79
  • Peer Reviewed
• [Journal Article] Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine. (2013)
  • Author(s): Shibata Itsuko
  • Journal Title: Scand Cardiovasc J. Volume: 47 Issue: 1 Pages: 50-57
  • DOI: 10.3109/14017431.2012.732236
  • NAID: 120006985770
  • Peer Reviewed
• [Journal Article] Olprinone, a phosphodiesterase type III inhibitor, has pharmacological postconditioning properties against renal and heart ischemia-reperfusion injury. (2013)
  • Author(s): Tsurunaga Y, Tosaka S, Tosaka R, Miyoshi H, Maekawa T, Cho S, Sumikawa K.
  • Journal Title: Anesthesia and Resuscitation Volume: 49 Pages: 75-79
  • Peer Reviewed
• [Journal Article] Fasudil administered during early reperfusion protects against myocardial infarction through activation of PI3K/Akt/NOS pathway in rats (2012)
  • Author(s): 前川拓治、趙成三、一ノ宮大雅、戸坂真也、松本周平、柴田伊津子、原哲也、澄川耕二
  • Journal Title: Circ Cont Volume: 33 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs. (2012)
  • Author(s): Yoshitomi Osamu
  • Journal Title: Shock Volume: 38 Issue: 1 Pages: 92-97
  • DOI: 10.1097/shk.0b013e318254d3fb
  • Peer Reviewed
• [Journal Article] High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels (2012)
  • Author(s): Taiga Ichinomiya, Sungsam Cho, Ushio Higashijima, Shuhei Matsumoto, Takuji Maekawa, Koji Sumikawa
  • Journal Title: Cardiovasc Diabetol Volume: 11(1) Issue: 1 Pages: 28-28
  • DOI: 10.1186/1475-2840-11-28
  • NAID: 120006985422
  • Peer Reviewed
• [Journal Article] Hyperglycemia raises the threshold of levosimendan-but not milrinone-induced postconditioning in rat hearts (2012)
  • Author(s): 松本周平, 趙成三, 戸坂真也, 東島潮, 前川拓治, 原哲也, 澄川耕二
  • Journal Title: Cardiovascular Diabetology Volume: 11:4 Issue: 1 Pages: 4-4
  • DOI: 10.1186/1475-2840-11-4
  • Peer Reviewed
• [Journal Article] Fasudil administered during early reperfusion protects against myocardial infarction through activation of PI3K/Akt/NOS pathway in rats. (2012)
  • Author(s): Maekawa T, Cho S, Ichinomiya T, Tosaka S, Matsumoto S, Shibata I, Hara T, Sumikawa K.
  • Journal Title: Circ Cont Volume: 33 Pages: 96-103
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. (2012)
  • Author(s): 酒井一介、趙 成三、柴田伊津子、吉富 修、前川拓治、澄川耕二
  • Journal Title: Scand Cardiovasc J Volume: 46 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts. (2012)
  • Author(s): 松本周平、趙 成三、戸坂真也、東島 潮、前川拓治、原 哲也、澄川耕二
  • Journal Title: Cardiovasc Diabetol Volume: 12 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine (2011)
  • Author(s): Sakai Kazuyuki
  • Journal Title: Scand Cardiovasc J Volume: 46 Issue: 3 Pages: 183-188
  • DOI: 10.3109/14017431.2012.659676
  • Peer Reviewed
• [Presentation] 代謝性アシドーシスがミルリノンとドブタミンの心血行動態に与える影響 (2014)
  • Author(s): 趙成三、前川拓治、吉富修、一ノ宮大雅、槇田徹次
  • Organizer: 第41回日本集中治療医学会学術集会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2014-02-28
• [Presentation] 代謝性アシドーシスがミルリノンとドブタミンの心血行動態に与える影響 (2014)
  • Author(s): 趙 成三、前川拓治、吉富 修、一ノ宮大雅、槇田徹次
  • Organizer: 第41回日本集中治療医学会学術集会
  • Place of Presentation: 京都市 国立京都国際会館
• [Presentation] Anesthesiological Features of Living Donor Liver Transplantation operations (2013)
  • Author(s): 趙成三
  • Organizer: Congress of Surgeons of Kazakhstan with International Participation
  • Place of Presentation: Almaty
  • Year and Date: 2013-04-08
• [Presentation] 麻酔関連薬の肝・腎保護作用に関する現状 (2011)
  • Author(s): 趙成三
  • Organizer: 日本心臓血管麻酔学会第16回学術大会
  • Place of Presentation: 旭川グランドホテル(北海道)
  • Year and Date: 2011-10-08
• [Presentation] 麻酔関連薬の肝・腎保護作用に関する現状
  • Author(s): 趙 成三
  • Organizer: 日本心臓血管麻酔学会第16回学術大会(招待講演)
  • Place of Presentation: 旭川グランドホテル（北海道）
• [Book] －For Professional Anesthesiologists－吸入麻酔 第5章．吸入麻酔薬の臓器保護作用と毒性，３．虚血肝・腎保護作用 (2014)
  • Author(s): 趙 成三，前川拓治
  • Total Pages: 15
  • Publisher: 克誠堂出版
• [Book] 8.アルプロスタジルアルファデクス-For Professional Anesthesiologists-吸入麻酔薬心血管作動薬山陰道明、平田直之編III.心血管作動薬の使用法 (2013)
  • Author(s): 趙成三、前川拓治
  • Publisher: 克誠堂出版
• [Book] 9.ホスホジエステラーゼIII阻害薬-For Professional Anesthesiologists-心血管作動薬土田英昭編III.心血管作動薬の使用法 (2013)
  • Author(s): 趙成三
  • Publisher: 克誠堂出版
• [Book] 8.アルプロスタジルアルファデクス-For Professional Anesthesiologists-心血管作動薬土田英昭編III.心血管作動薬の使用法 (2013)
  • Author(s): 趙成三
  • Publisher: 克誠堂出版
• [Remarks]
  • URL: http://research.jimu.nagasaki-u.ac.jp/IST
• [Remarks]
  • URL: http://gyoseki.jimu.nagasaki-u.ac.jp/IST
• [Remarks] 長崎大学研究者総覧データベース
  • URL: http://research.jimu.nagasaki-u.ac.jp/IST
• [Remarks] 長崎大学教員個人業績
  • URL: http://gyoseki.jimu.nagasaki-u.ac.jp/IST
• [Remarks] 長崎大学 研究者総覧データベース
  • URL: http://research.jimu.nagasaki-u.ac.jp/IST
• [Remarks]
  • URL: http://research.jimu.nagasaki-u.ac.jp/IST
• [Remarks] または
  • URL: http://gyoseki.jimu.nagasaki-u.ac.jp/IST