| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
In the septic rat model administered lipopolysaccharide(LPS), we established the method to measure in real time serum vitamin C levels by using an electron spin resonance spectrometer. Twenty four hours after high dose LPS, serum vitamin C decresed remarkably and the inflammatory response increased.
The new antioxidant, ETS-GS which has very strong antiinflammatory and antioxidant effects tended to inhibit serum vitamin C loss and the infllammatory response. The hormones of pituitary and adrenal, however, didn't increase significantly. Therefore, I could not figure out the relationship between the ETS-GS and the hypothalamus-pituitary-adrenal axis.
In the future, I will plan to use the SMP30 knockout mouse which cannot synthesize vitamin C like human and continue this study.
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