The abnormality of the descending inhibitory system in the brain stem by the peripheral axotomy and neuropathic pain
| Project/Area Number |
23592314
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Kansai University of Health Sciences |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OHSHIMA Minoru (20342230)
UCHIDA Yasuyuki (80388678)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
|---|
| Keywords | 下行性抑制系 / 脊髄後角ニューロン / パッチクランプ法 / ラット |
|---|
| Research Abstract |
It is known that the noxious information in the peripheral tissues, the visceral organs, the skin and others, is carried by the primary sensory neurons with A delta and C fibers to the central nervous system via spinal dorsal horn. The information is thought to be also negatively regulated by the serotonergic and the noradrenergic neurons in the brain stem according to the situation. In our study, many neurons in the deep lamina of dorsal horn were excited by substance P, which is the neuromodulator in the nociceptors. This result mean the these neurons are involved in the transmission or modulation of pain sensation. Moreover, surprisingly, some of these are suggested to be excitatory, but not inhibitory, regulated by serotonergic and noradrenergic neurons. Although the physiological roles for the neural mechanism inferred from our present findings is unknown, the previous descending inhibitory system will have to be be reconsidered.
|
Report
(4 results)
Research Products
(8 results)
-
-
-
-
-
-
-
-
[Book] 鍼灸医学大事典2012
Author(s)
樫葉均（分担： 生理学領域用語執筆）
Total Pages
850
Publisher
医歯薬出版
Related Report
