| Project/Area Number |
23592316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HARA Koji 産業医科大学, 医学部, 講師 (20331001)
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| Co-Investigator(Kenkyū-buntansha) |
HARANISHI Yasunori 産業医科大学, 医学部, 講師 (90449942)
KATAOKA Kazunori 産業医科大学, 医学部, 助教 (70441839)
NAKAMURA Motohiro 産業医科大学, 医学部, 助教 (30461578)
SATA Takeyoshi 産業医科大学, 医学部, 教授 (60128030)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経障害性疼痛 / 鎮痛薬 / 行動薬理学 / 脳室内投与 / 髄腔内投与 / Kチャネル |
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| Research Abstract |
The analgesic effects of three groups of potassium (K) channel openers were examined using a rat neuropathic pain model. Several K channel openers were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia induced by chronic constriction injury to the sciatic nerve. Spinally- and supraspinally-applied calcium-activated potassium channel (Kca) openers attenuated mechanical and cold hyperalgesia. On the other hand, the openers of voltage-dependent K channel and two-pore-domain K channel had no effect on the hyperalgesia displayed in the rats. The Kca channel openers may exert antihyperalgesic effects both in the spinal cord and the brain.
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